Association between TM6SF2 rs58542926 T/C gene polymorphism and significant liver fibrosis: A meta-analysis

Abstract

Aim: To further explore the association between Transmembrane 6 superfamily member 2(TM6SF2) rs58542926 T/C gene polymorphism and hepatic fibrosis. Materials and Methods: In this study the MEDLINE, PubMed, EMBASE, and CENTRAL databases were queried from inception to March 21, 2020. According to inclusion and exclusion criteria; case control studies assessing the relationship between TM6SF2 rs58542926 T/C gene polymorphism and significant liver fibrosis were selected. NOS scale was used to evaluate the included literature. Stata 12.0 software was used for data analysis. Results: In this meta analysis: a total of 7 articles, including 2286 patients were included. Statistical analysis showed that the TM6SF2 gene polymorphism was associated with significant liver fibrosis in the allele contrast, recessive dominant models (T vs. C, OR=1.292, 95%CI 1.035-1.611, P=0.023; TT vs. CT+CC, OR=2.829, 95%CI 1.101-7.267, P=0.031). No significant publication bias was found after Egger′s test.

Molecular Screening via Sanger Sequencing of the Genetic Variants in Non-Alcoholic Fatty Liver Disease Subjects in the Saudi Population: A Hospital-Based Study

“…A meta-analysis study on the E167K variant in preventing CAD and conferring risk for NAFLD revealed that the rs58542926 polymorphism is a key regulator of blood lipid characteristics in global studies [62]. Metaanalysis studies have also shown the E167K (rs58542926) polymorphism in TM6SF2 in NAFLD and other human diseases, such as carcinoma and liver fibrosis [42,[62][63][64]. For the H63D polymorphism, 21% of heterozygotes and 2.1% of homozygous variants were present in NAFLD cases in the present study.…”

Association of PNPLA3 (rs738409) & TM6SF2 (rs58542926) and ATG16L1 (rs2241880) genetic variants with susceptibility to hepatocellular carcinoma in a group of Egyptian patients with HCV-induced liver cirrhosis

“…Another SNP associated with impaired intracellular lipid regulation in the hepatic cells is rs58542926, E167K in the transmembrane 6 superfamily member 2 gene, which has a vital role in the development of liver cirrhosis and HCC [ 17 ]. TM6SF2 gene is located on chromosome 19, its expression produces the TM6SF2 protein, which is implicated in the risk of NASH and also induces hepatic fibrosis [ 18 ]. The T allele of rs58542926 increases the risk of liver disease and HCC development [ 15 ].…”