Association between TLR2 + 2477G/A polymorphism and bacterial meningitis: a meta-analysis

Abstract

Toll-like receptor 2 (TLR2) is a key member of TLRs, which is crucial in the initial inflammatory response against bacteria. TLR2, is also the initial barrier against bacterial infection and plays an important role in recognising a variety of bacterial lipoproteins. Several studies have been performed to investigate the TLR2 + 2477G/A polymorphism and bacterial meningitis susceptibility. Unfortunately, the results of previous studies were controversial. Therefore, we performed a meta-analysis to derive a more precise estimation of the association. The association between the TLR2 + 2477G/A polymorphism and bacterial meningitis susceptibility was assessed by odds ratios together with their 95% confidence intervals (CI). Six studies were enrolled in the present meta-analysis. Overall, no significant association between TLR2 + 2477G/A polymorphism and bacterial meningitis risk were found under allele contrast (A vs. G: OR = 1.15, 95% CI = 0.93-1.43, P = 0.202), recessive genetic model (AA vs. AG/GG: OR = 1.12, 95% CI = 0.90-1.41, P = 0.313). The significant association was found between TLR2 + 2477G/A polymorphism and pneumococcal meningitis risk under allele contrast (A vs. G: OR = 1.54, 95% CI = 1.01-2.36, P = 0.046), recessive genetic model (AA vs. AG/GG: OR = 1.63, 95% CI = 1.03-2.57, P = 0.035). We conclude that TLR2 + 2477G/A polymorphism is not associated with meningococcal meningitis risk but contributes an increased risk of pneumococcal meningitis.

Genetic polymorphism of IL-17 influences susceptibility to recurrent pregnancy loss in a Chinese population

“…Genetic polymorphisms vary significantly across different countries and regions, impacted by the distinct racial backgrounds present. [18][19][20][21][22][23][24] Our research focuses on the Chinese population, whose genetic polymorphisms differ from those observed in Egypt and Saudi Arabia. Given that Egypt is in North Africa and Saudi Arabia is in West Asia, their genetic profiles are markedly different from those of the Chinese population.…”

Tumor necrosis factor‐α polymorphism and risk of primary nephrotic syndrome: A case–control study and meta‐analysis

“…The inclusion of a substantial sample size is crucial for the study of gene polymorphism and has been demonstrated to be beneficial in previous literature. 34 , 35 , 36 , 37 , 38 , 39 , 40 However, there are certain limitations that must be acknowledged. Although our study design was innovative in exploring TNF‐α rs1800629 polymorphism in PNS patients, there is always room for improvement.…”

MMP-3 gene regulates the carcinogenesis and metabolic process of ovarian cancer, evidence from a Chinese population: Observational study and meta-analysis

“…All methods applying the present meta-analysis were based on published literatures. [11][12][13][14][15][16][17][18][19][20][21][22][23][24] 2.4. Statistical analysis SPSS17, STATA11 software, t test, χ2 test statistic tools were applied in our investigation, as reported by previous literatures.…”