Association between timely initiation of hepatitis B vaccine and completion of the hepatitis B vaccine and national immunization program vaccine series

Abstract

Coverage with a timely first dose of HB vaccine is high in children in the community and newborns in hospital, and timely receipt of the first dose of HB vaccine is associated with an increased likelihood of completing the HB vaccine series and the NIPV series in Fujian, China.

Hepatitis B vaccination among 1997-2011 birth cohorts in rural China: the potential for further catch-up vaccination and factors associated with infant coverage rates

“…17 Additional information concerning the relationship between HBV vaccination and place of birth has been reported by other studies. 12,15,16,19,31,32 Our results for the timely birth dose correspond well with the findings of the most recent national sero-survey, in particular for the younger cohorts, while our results show a consistently lower rate of completed vaccination in the first year of life. 21 Given that urban areas, where the vaccine was more readily available and coverage rates tended to be higher than in rural areas, were not part of our survey, it is likely that our coverage estimates would be lower than the national estimates.…”

Relationship between receipt of substitutable for-fee vaccines and completion of the expanded programme on immunisation: a cross-sectional study in Fujian, China

“…Hence, receiving the SFV may be an indicator of the economic conditions and vaccination awareness of children’ families, and might ensure better service from the staff of the IC, resulting in children having better compliance with immunisation and being more likely to complete the EPI. 1 2 9 22–26 …”

“…It took about 10 min to complete a questionnaire. Newborns who received a HepB in the first and second day of birth were deemed to finish the vaccine within 24 hours and have a timely HepB first dose in our analysis, 1 because it is hard to calculate the exact hours that the babies receive the vaccine.…”

“…China has an expanded programme on immunisation (EPI) which includes one dose of Bacille Calmette-Guerin vaccine (BCG), three doses of hepatitis B vaccine (HepB), four doses of oral live attenuated polio vaccine (OPV), four doses of acellular pertussis diphtheria tetanus vaccine (DTaP), two doses of measles-containing vaccine (MCV), two doses of group A meningococcal polysaccharide vaccine (MPSV-A), two doses of live-attenuated Japanese encephalitis vaccine (JE-L), one dose of live-attenuated hepatitis A vaccine (HepA-L), one dose of diphtheria tetanus vaccine (DT) and two doses of meningococcal A+C polysaccharide vaccine (MPSV-AC). 1 The EPI vaccines are mostly produced by state-owned pharmaceutical companies and are provided to the public as free vaccines. In addition, parents can choose to purchase variants that are for-fee vaccines, which are mostly manufactured by private enterprises based in China or are imported from abroad.…”

“…Better economic capacities and higher vaccination awareness were significantly related to completion of the EPI vaccine series. 13 14 Moreover, previous studies had revealed that children who had initiated a delayed first dose of HepB 1 and whose parents have lower educational levels were less likely to complete the EPI. 15 Therefore, it is reasonable to hypothesise that(1) children receiving the SFV might promote their completion of the EPI and (2) the relationship between the SFV administration and the EPI completion might be modified by parents’ education level and initiation time of the HepB first dose.…”