Association between time of hospitalization with acute myocardial infarction and in-hospital mortality

Wu, Jianhua; Hall, Marlous; Dondo, Tatendashe B; Wilkinson, Chris; Ludman, Peter; deBelder, Mark; Fox, Keith A.A.; Gale, Chris P

doi:10.1093/eurheartj/ehy835

Cited by 26 publications

(21 citation statements)

References 36 publications

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“…The high incidence and mortality of acute myocardial infarction have long threatened human health and longevity [1,4]. Treatments such as thrombolysis or percutaneous coronary intervention can result in severe MIRI [3,5]. As MIRI is predominantly caused by excessive production of ROS [42], an ROS-responsive drug delivery system would be an appropriate treatment strategy method to release drugs at the injury site and reduce drug accumulation.…”

Section: Discussionmentioning

confidence: 99%

“…Reperfusion following thrombolytic or primary percutaneous coronary intervention is considered to be the most effective treatment [1,2]. However, an incidence of 10%-25% of recurrent AMI and a hospital mortality rate of 6%-14% in patients with myocardial ischemia-reperfusion injury (MIRI) has been reported [3,4]. Potential mechanisms for MIRI include inflammation, energy metabolism disorder, oxidative stress, and apoptosis [5].…”

Section: Introductionmentioning

confidence: 99%

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Ginsenoside Rg3-loaded, reactive oxygen species-responsive polymeric nanoparticles for alleviating myocardial ischemia-reperfusion injury

Wang

Guo

et al. 2020

Journal of Controlled Release

121

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Myocardial ischemia-reperfusion injury (MIRI) is a serious threat to the health and lives of patients without any effective therapy. Excessive production of reactive oxygen species (ROS) is considered a principal cause of MIRI. Some natural products, including ginsenoside Rg3 (Rg3), exhibit robust antioxidant activity. However, the lack of an effective delivery strategy for this hydrophobic compound hinders its clinical application. In addition, therapeutic targets and molecular mechanisms of Rg3 require further elucidation to establish its mode of action. This study aimed to generate ROS-responsive nanoparticles (PEG-b-PPS) via the self-assembly of diblock copolymers of poly (ethylene glycol) (PEG) and poly (propylene sulfide) (PPS) and use them for Rg3 encapsulation and delivery. We identified FoxO3a as the therapeutic target of Rg3 using molecular docking and gene silencing. In rat ischemia-reperfusion model, an intramyocardial injection of Rg3~loaded PEG-b-PPS nanoparticles improved the cardiac function and reduced the infarct size. The mechanism of action was established as Rg3 targeting of FoxO3a, which inhibited the promotion of oxidative stress, inflammation, and fibrosis via downstream signaling pathways. In conclusion, this approach, involving ROS-responsive drug release, together with the identification of the target and mechanism of action of Rg3, provided an *

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ginsenoside Rg3-loaded, reactive oxygen species-responsive polymeric nanoparticles for alleviating myocardial ischemia-reperfusion injury

Wang

Guo

et al. 2020

Journal of Controlled Release

121

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“…Acute myocardial infarction (AMI) and post-infarction chronic heart failure (CHF) are the leading causes of mortality worldwide [1]. Despite advancements in therapy for AMI and CHF during the past decades, it is necessary to find new therapeutics to decrease the morbidity and mortality from AMI.…”

Section: Introductionmentioning

confidence: 99%

IGF-1 enhances BMSC viability, migration, and anti-apoptosis in myocardial infarction via secreted frizzled-related protein 2 pathway

et al. 2020

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Background: Bone marrow mesenchymal stem cell (BMSC) transplantation represents a promising therapeutic strategy for ischemic heart disease. However, its effects are hampered by the poor viability of transplanted cells and the hostile microenvironment of the ischemic region. Insulin-like growth factor-1 (IGF-1) is an important paracrine growth factor of BMSC and plays an important role in the properties of BMSC. Here, we investigated whether overexpressing IGF-1 could enhance the BMSC viability, migration, anti-apoptosis, and protective effects of cardiomyocytes, and explore the underlying mechanisms' focus on the role of the AKT/secreted frizzled-related protein 2 (SFRP2)/β-catenin pathway. Methods: We constructed BMSCs overexpressing insulin-like growth factor-1 (BMSCs-IGF-1) or empty vector (BMSCs-NC) using lentivirus, and evaluated cell survival, proliferation, and migration under normoxic and hypoxic conditions. Co-culture of rat cardiomyoblasts with BMSCs was performed to explore the paracrine effect of BMSCs-IGF-1 for rescuing cardiomyoblasts under hypoxia. Transplantation of BMSCs in acute myocardial infarction rats was used to explore the effect of BMSCs-IGF-1 therapy. Results: BMSCs-IGF-1 exhibited a higher cell proliferation rate, migration capacity, and stemness, and were more resistant to apoptosis under hypoxia. Overexpression of IGF-1 upregulated the expression of total and nuclear βcatenin via the AKT-secreted frizzled-related protein 2 (SFRP2) pathway, which enhanced cell survival. Inhibition of AKT or SFRP2 knockdown by siRNA significantly antagonized the effect of IGF-1 and decreased the expression of βcatenin. The expression of β-catenin target genes, including cyclin D1 and c-Myc, were accordingly decreased. Moreover, BMSCs-IGF-1 could rescue cardiomyoblasts from hypoxia-induced apoptosis and preserve cell viability under hypoxia. Transplantation of BMSCs-IGF-1 into myocardial infarction rats greatly reduced infarct volume than BMSCs-NC, with significantly greater expression of SFRP2 and β-catenin. Conclusions: These results suggest that in BMSCs overexpressing IGF-1, SFRP2 is an important mediator for the enhancement of stem cell viability via activating, rather than antagonizing, the Wnt/β-catenin pathway.

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“…The study by Mehta et al successfully revealed increased reperfusion with percutaneous coronary intervention (PCI) and significant reduction in PCI mortality but increased cost and a non-significant reduction in mortality overall amongst all treatment pathways. As we know, telemedicine is increasingly common due to the COVID-19 pandemic and many studies have shown the usefulness of a telemedicine system for the early diagnosis of acute myocardial infarction and consequent reperfusion time reduction 2 .…”

Section: Universitas Muhammadiyah Banten Indonesiamentioning

confidence: 99%

Letter: Impact of a telemedicine-guided, population-based, STEMI network on reperfusion strategy, efficiency, and outcomes

Laksono¹

2021

AsiaIntervention

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Association between time of hospitalization with acute myocardial infarction and in-hospital mortality

Abstract: This is a repository copy of Association between time of hospitalization with acute myocardial infarction and in-hospital mortality.

Cited by 26 publications

References 36 publications

Ginsenoside Rg3-loaded, reactive oxygen species-responsive polymeric nanoparticles for alleviating myocardial ischemia-reperfusion injury

Ginsenoside Rg3-loaded, reactive oxygen species-responsive polymeric nanoparticles for alleviating myocardial ischemia-reperfusion injury

IGF-1 enhances BMSC viability, migration, and anti-apoptosis in myocardial infarction via secreted frizzled-related protein 2 pathway

Letter: Impact of a telemedicine-guided, population-based, STEMI network on reperfusion strategy, efficiency, and outcomes

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