Association between thyroid function and psychotic symptoms in adolescents with major depressive disorder: A large sample sized cross-sectional study in China

Yang, Ruchang; Zhu, Feng; Yue, Yan; Lu, Xinchuan; Zhu, Ping; Li, Zhe; Zhao, Xuechao; Yang, Xuna; Zhou, Yongjie; Du, Xiangdong

doi:10.1016/j.heliyon.2023.e16770

Cited by 2 publications

(1 citation statement)

References 56 publications

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“…Though previous investigations have focused on relationship between psychotic symptoms and thyroid function, no consistent consensus has been reached thus far [ 15 , 24 – 29 ]. Besides, a limited number of studies have focused on their relationship among MDD patients [ 30 – 32 ]. Consequently, this study delves into the specific association between TSH and PD.…”

Section: Introductionmentioning

confidence: 99%

Non-linear relationship between TSH and psychotic symptoms on first episode and drug naïve major depressive disorder patients: a large sample sized cross-sectional study in China

Yang,

Li,

Zhu

et al. 2024

BMC Psychiatry

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Introduction Psychotic depression (PD) is characterized by the co-occurrence of emotional dysfunction and psychotic symptoms such as delusions and hallucinations with poor clinical outcomes. TSH may involve in the development of PD. This study aims to explore relationship between TSH and PD. Methods A total of 1718 outpatients diagnosed as FEDN MDD were recruited in this study. The relationship between PD and TSH was evaluated using multivariable binary logistic regression analysis. To assess the presence of non-linear associations, a two-piecewise linear regression model was employed. Furthermore, interaction and stratified analyses were conducted with respect to sex, education, marital status, comorbid anxiety, and suicide attempt. Results Multivariable logistic regression analysis revealed that TSH was positively associated with the risk of PD after adjusting for confounders (OR = 1.26, 95% CI: 1.11 to 1.43; p < 0.05). Smoothing plots showed a nonlinear relationship between TSH and PD, with the inflection point of TSH being 4.94 mIU/L. On the right of the inflection point, for each unit increase in serum TSH level on the right side of the inflection point, the probability of PD increased substantially by 47% (OR = 1.47, 95% CI: 1.25 to 1.73, p < 0.001), while no significant association was observed on the left side of the inflection point (OR = 0.87, 95% CI: 0.67 to 1.14, p = 0.32). Conclusion Our investigation showed a nonlinear TSH-PD relationship in FEDN MDD patients, thus contributing to effective intervention strategies for psychotic symptoms in depression patients.

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Section: Introductionmentioning

confidence: 99%

Non-linear relationship between TSH and psychotic symptoms on first episode and drug naïve major depressive disorder patients: a large sample sized cross-sectional study in China

Yang,

Li,

Zhu

et al. 2024

BMC Psychiatry

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Comorbidity Patterns Analysis in Patients with Thyroid Disease Using Large-Scale Electronic Medical Records: Network-Based Study (Preprint)

Huang,

Chen,

Wang

et al. 2023

Preprint

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BACKGROUND Thyroid disease (TD) is a prominent endocrine disorder and an increasing worldwide public health concern, yet the phenotypic comorbidity pattern of TD patients remains unclear. OBJECTIVE We aimed to use the network-based method to systematically analyze and provide a complete picture of the comorbidity patterns for TD patients. METHODS In this retrospective observational study, we extracted comorbidities of nearly 20 thousand adults diagnosed with TD from a tertiary hospital in China, from 2018 to 2022. All comorbidities were identified by ICD-10 (International Classification of Diseases, 10th Revision) codes at 3 digits, and we focused on comorbidities with >2% prevalence. We divided patients into several subgroups by sex, age, and disease type (thyroid cancer [TC] or benign TD [BTD]). Phenotypic comorbidity network (PCN), where comorbidities were used as nodes and their significant correlations as edges, was constructed across all TD patients and different subgroups. The comorbidity associations and differences in the PCN of each subgroup were analyzed and compared. RESULTS The final cohort included 18,311 TD patients with 72 comorbidities. Most patients were female (61.1%), and 6.2% had TC. The mean age of TD patients was 57.2 years. Approximately one-third (31.2%) of patients had less than three comorbidities, and more than half (54.0%) had at least five comorbidities. Except nontoxic goiter and hypothyroidism that with the highest prevalence (67.8% and 34.0%, respectively), other most prevalent comorbidities were hypertension (35.1%), liver disease (22.0%), and diabetes (16.8%). The prevalence of single comorbidity was different in each subgroup. TD patients’ PCN contained 72 comorbidities and 492 comorbid disease pairs. Comorbidities were closely associated with cardio-cerebrovascular diseases and diabetes. Males and females shared 103 disease pairs with 55 comorbidities. Male-female disparities occurred in diseases coexisting. Patients with BTD had more comorbidities with higher prevalence and more complex disease coexistence relationships, whereas those with TC had a few co-existing severe diseases. CONCLUSIONS TD patients had complex comorbidity patterns, especially with cardio-cerebrovascular diseases and diabetes. Comorbidities’ associations among different TD subgroups were various. This study is expected to improve the understanding of TD patients’ comorbidity patterns and enhance the integrated management of patients.

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Association between thyroid function and psychotic symptoms in adolescents with major depressive disorder: A large sample sized cross-sectional study in China

Cited by 2 publications

References 56 publications

Non-linear relationship between TSH and psychotic symptoms on first episode and drug naïve major depressive disorder patients: a large sample sized cross-sectional study in China

Non-linear relationship between TSH and psychotic symptoms on first episode and drug naïve major depressive disorder patients: a large sample sized cross-sectional study in China

Comorbidity Patterns Analysis in Patients with Thyroid Disease Using Large-Scale Electronic Medical Records: Network-Based Study (Preprint)

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