Association between thyroid dysfunction and perinatal outcomes in women with gestational hypertension: a retrospective study

Gui, Juan; Xu, Wangming; Zhang, Jie

doi:10.1186/s12884-020-2805-6

Cited by 10 publications

(6 citation statements)

References 44 publications

(45 reference statements)

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“…A recent case-control study found that compared with the late-onset pre-eclampsia group (>34 weeks), the early-onset pre-eclampsia group had lower average birthweight of infants and a higher incidence of other adverse pregnancy outcomes, such as preterm birth. 32 Jelin et al 33 also found that the rate of SGA in newborns of women with early-onset pre-eclampsia was three times higher than that of women without pre-eclampsia (18% vs 6%). This is consistent with the results of our study.…”

Section: Discussionmentioning

confidence: 95%

“…Few literatures have compared the effects of gestational hypertension and pre‐eclampsia occurring at different time on adverse pregnancy outcomes. A recent case‐control study found that compared with the late‐onset pre‐eclampsia group (>34 weeks), the early‐onset pre‐eclampsia group had lower average birthweight of infants and a higher incidence of other adverse pregnancy outcomes, such as preterm birth 32 . Jelin et al 33 also found that the rate of SGA in newborns of women with early‐onset pre‐eclampsia was three times higher than that of women without pre‐eclampsia (18% vs 6%).…”

Section: Discussionmentioning

confidence: 99%

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Impact of gestational hypertension and preeclampsia on low birthweight and small‐for‐gestational‐age infants in China: A large prospective cohort study

Liu

et al. 2021

J of Clinical Hypertension

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Studies have shown that maternal blood pressure level is associated with neonatal birthweight, but the results are not exactly consistent. As the most common hypertensive disorders during pregnancy, the mechanism of gestational hypertension and pre‐eclampsia that affect fetal growth remain unclear. Our objective was to examine the association of gestational hypertension and pre‐eclampsia with the risk of low birthweight (LBW) and small‐for‐gestational‐age (SGA). Data were obtained from the China–US Collaborative Project for Neural Tube Defects Prevention, a large population‐based cohort study. We selected participants who were registered in two southern provinces, had exact information on gestational blood pressure and pregnancy outcomes, and were not affected by chronic hypertension. Logistic regression was used to adjust for the effects of the main potential confounders, including age, body mass index, education, occupation, ethnicity, folic acid use, and parity. The overall incidences of LBW and SGA were 2.25% and 5.86%, respectively. The incidences of LBW/SGA were 3.58%/7.58% and 6.02%/10.67% for gestational hypertension and pre‐eclampsia group, relative to 2.11%/5.68% and 2.16%/5.74% for normal group. The adjusted odds ratios associated with gestational hypertension/pre‐eclampsia were 1.77 (95% CI: 1.63, 1.92)/3.01 (95% CI: 2.67, 3.40) for LBW and 1.40 (95% CI: 1.32, 1.48)/2.02 (95% CI: 1.84, 2.22) for SGA, respectively. The early onset of gestational hypertension/pre‐eclampsia appeared to be a relatively more detrimental exposure window for both LBW and SGA. Our results support an association between gestational hypertension or pre‐eclampsia and the increased risk of LBW and SGA.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Impact of gestational hypertension and preeclampsia on low birthweight and small‐for‐gestational‐age infants in China: A large prospective cohort study

Liu

et al. 2021

J of Clinical Hypertension

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“…We found that pregnant women with thyroid diseases had increased risk for late-onset PE with severe features, despite receiving treatment and having no symptoms of thyroid dysfunction. Previous reports [ 47 , 48 ] have also found that thyroid dysfunction, especially hypothyroidism, is associated with risk of PE, which had increase in endothelial cell dysfunction. In addition to some specific maternal risk factors related to late-onset PE with severe features, we found that serum inhibin A during the second trimester had an additive value for improving the prediction of PE.…”

Section: Discussionmentioning

confidence: 83%

Combined maternal risk factors and the Quadruple test to predict late-onset preeclampsia in pregnant Thai women

Bunyapipat

Pruksanusak

Suwanrath

et al. 2023

BMC Pregnancy Childbirth

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Background This study aimed to evaluate the predictive power of a model combining maternal risk factors and the Quadruple screen test for late-onset preeclampsia (PE). Methods All pregnant women that received the Quadruple test for Down syndrome at 15+ 0-20+ 6 weeks’ gestation were recruited. Maternal serum α-fetoprotein, β-human chorionic gonadotropin, unconjugated estriol, and inhibin A were measured as multiples of the median. A logistic regression model was used to identify predictors associated with late-onset PE with severe features. The receiver operating characteristic (ROC) curve and area under the curve (AUC) were used to assess the model’s predictive ability. Results Fifty-five of the 2,000 pregnant women had PE, and 31 of 55 women had late-onset PE. Multivariate analysis identified maternal age ≥ 35 years, inhibin A, history of previous PE, history of infertile, cardiac disease, chronic hypertension, and thyroid disease as significant risk factors. The area under the curve of the receiver operating characteristic curve was 0.78. The likelihood ratio to predict late-onset PE was 49.4 (total score > 60). Conclusions Our model combining serum inhibin A with maternal risk factors was useful in predicting late-onset PE. Close monitoring of these patients is recommended.

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“…Maternal hypothyroidism is one of the most common gestational metabolic disorders and affects around 2–3% of the population [ 1 ]. Women with maternal hypothyroidism have an increased risk of miscarriage, premature birth, placental abruption, preeclampsia, gestational diabetes, and intrauterine growth restriction [ 2 , 3 , 4 , 5 , 6 , 7 , 8 ], while in hypothyroid female rats the placental development is compromised, with alteration of immunology and trophoblastic endocrine function [ 7 , 9 , 10 , 11 , 12 , 13 , 14 ]. In addition, a recent study demonstrated that maternal hypothyroidism also causes oxidative stress and endoplasmic reticulum stress at the maternal-fetal interface of rats [ 15 ], suggesting that this cellular stress may result from the failure of intrauterine trophoblastic migration observed in these animals [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Kisspeptin Suppresses Inflammasome-NLRP3 Activation and Pyroptosis Caused by Hypothyroidism at the Maternal-Fetal Interface of Rats

Santos

Cordeiro

Santos

et al. 2023

IJMS

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Gestational diseases such as preeclampsia and gestational diabetes cause inflammasome activation and pyroptosis in the placenta and changes in placental kisspeptin levels. Although maternal hypothyroidism also reduces the kisspeptin/Kiss1R system at the maternal-fetal interface, there is still no information on whether this dysfunction causes inflammasome activation and pyroptosis in the placenta or influences the modulatory role of kisspeptin in these processes. This study aimed to evaluate whether hypothyroidism activates the inflammasome-NLRP3 pathway and pyroptosis at the maternal-fetal interface of rats and whether kisspeptin can modulate these processes. Hypothyroidism was induced in Wistar rats by the administration of propylthiouracil. Kisspeptin-10 (Kp10) treatment began on the 8th day of gestation (DG). Gene and/or protein expressions of NLRP3, Caspase 1, IL-1β, IL-18, and Gasdermin D (Gsmd) were evaluated in the deciduae and placentae at the 18th DG. Hypothyroidism increased the decidual and placental stainings of NLRP3, IL-1β, and Gasdermin D, and increased the gene expressions of Nlrp3, Ilβ, and Il18 in the placenta and of Gsmd in the decidua. Treatment with Kp10 suppressed the increase in NLRP3/Nlrp3, IL-1β, Il18, and Gasdermin D/Gsmd caused by hypothyroidism at the maternal-fetal interface. However, Kp10 increased the placental gene expressions of Casp1 and Il1β. The findings demonstrated that maternal hypothyroidism activated the inflammasome-NLRP3 pathway and pyroptosis at the maternal-fetal interface of rats and that treatment with Kp10 was able to block these processes, thus suggesting that kisspeptin analogues may be promising in the treatment of gestational diseases that involve inflammasome activation and pyroptosis.

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Association between thyroid dysfunction and perinatal outcomes in women with gestational hypertension: a retrospective study

Cited by 10 publications

References 44 publications

Impact of gestational hypertension and preeclampsia on low birthweight and small‐for‐gestational‐age infants in China: A large prospective cohort study

Impact of gestational hypertension and preeclampsia on low birthweight and small‐for‐gestational‐age infants in China: A large prospective cohort study

Combined maternal risk factors and the Quadruple test to predict late-onset preeclampsia in pregnant Thai women

Kisspeptin Suppresses Inflammasome-NLRP3 Activation and Pyroptosis Caused by Hypothyroidism at the Maternal-Fetal Interface of Rats

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