Association between the XPG Asp1104His and XPF Arg415Gln Polymorphisms and Risk of Cancer: A Meta-Analysis

Abstract

BackgroudThe XPG (xeroderma pigmentosum type G) Asp1104His and XPF (xeroderma pigmentosum type F) Arg415Gln polymorphisms had been implicated in cancer susceptibility. The previous published data on the association between XPG Asp1104His and XPF Arg415Gln polymorphisms and cancer risk remained controversial.Methodology/Principal FindingsTo derive a more precise estimation of the association between the XPG Asp1104His and XPF Arg415Gln polymorphisms and overall cancer risk, we performed a meta-analysis to investigate the association between cancer susceptibility and XPG Asp1104His (32,162 cases and 39,858 controls from 66 studies) and XPF Arg415Gln polymorphisms (17,864 cases and 20,578 controls from 32 studies) in different inheritance models. We used odds ratios with 95% confidence intervals to assess the strength of the association. Overall, significantly elevated cancer risk was found when all studies were pooled into the meta-analysis of XPG Asp1104His (dominant model: OR = 1.05, 95% CI = 1.00–1.10; Asp/His vs. Asp/Asp: OR = 1.06, 95% CI = 1.01–1.11). In the further stratified and sensitivity analyses, significantly decreased lung cancer risk was found for XPF Arg415Gln (dominant model: OR = 0.82, 95% CI = 0.71–0.96; Arg/Gln versus Arg/Arg: OR = 0.83, 95% CI = 0.71–0.97; additive model: OR = 0.83, 95% CI = 0.72–0.95) and significantly increased other cancer risk was found among hospital-based studies for XPG Asp1104His (dominant model: OR = 1.23, 95% CI = 1.02–1.49).Conclusions/SignificanceIn summary, this meta-analysis suggests that XPF Arg415Gln polymorphism may be associated with decreased lung cancer risk and XPG Asp1104His may be a low-penetrant risk factor in some cancers development. And larger scale primary studies are required to further evaluate the interaction of XPG Asp1104His and XPF Arg415Gln polymorphisms and cancer risk in specific populations.

Evaluation of the ERCC2 (Lys751Gln), MSH2 (gIVS12-6TC), RAD54 (Ala730Ala), XPC (Lys939Gln), XPG (Asp1104Hist), XRCC1 (Arg399Gln) and XRCC3 (Thr241Met) gene polymorphisms in the Ecuadorian population with retinoblastoma

“…On the other hand, several mechanisms are involved in the development of Rb such as the disruption of the DNA repair system [25]. The genomic alteration of this system has been associated with other types of cancer such as colorectal cancer (CRC) [26], glioma [27], lung cancer [28,29], head and neck squamous cell carcinoma [30], melanoma [31] and breast cancer [32].…”

“…Several studies have shown that SNPs of the XPG gene are associated with several cancers. The Asp1104Hist polymorphism helped to increase the risk of CRC [25,42]. He et al (2014) reported a significant decrease in the risk of melanoma for the C/C genotype (OR = 0.32; CI of 95% = 0.13-0.75; p < 0.05) [25].…”

“…The Asp1104Hist polymorphism helped to increase the risk of CRC [25,42]. He et al (2014) reported a significant decrease in the risk of melanoma for the C/C genotype (OR = 0.32; CI of 95% = 0.13-0.75; p < 0.05) [25]. In other studies a statistically significant risk of prostate cancer in individuals with C/C genotype (OR = 2.53, CI of 95% = 0.99-6.56; p < 0.05) was found.…”

DNA excision repair and double-strand break repair gene polymorphisms and the level of chromosome aberration in children with long-term exposure to radon

“…The COOH-terminal domain of the XpG protein contains many alkaline amino acids and changes the alkaline acid amino to an acid (His -Asp), which can significantly alter its ability to interact with other proteins. The results of a meta-analysis indicate that the replacement may be a risk factor for different types of cancer (He et al 2014).…”

Genetic Susceptibility to Lung Adenocarcinoma

“…Studies of DNA adduction/damage, including that produced by tobacco carcinogens and associated repair processes, have identiˆed various metabolic and DNA repair genes with functional polymorphisms (26,(36)(37)(38)(39)(40)(41). A recent meta-analysis showed that representative SNPs in TP53 (tumor protein p53), OGG1 (8-oxoguanine DNA glycosylase), CYP1A1 (cytochrome P450, family 1, subfamily A, polypeptide 1), and EPHX (epoxide hydrolase 1, microsomal (xenobiotic)) were associated with increased lung cancer risk (42)(43)(44)(45)(46) (Table 2).…”