Association Between the Visceral Adiposity Index and Homeostatic Model Assessment of Insulin Resistance in Participants With Normal Waist Circumference

Abstract

We assessed the correlation between the visceral adiposity index (VAI; a useful indicator of adipose distribution and function) and homeostatic model assessment of insulin resistance (HOMA-IR) in participants with normal waist circumference. A cross-sectional study was conducted, which included 1834 Chinese adults. The blood pressure, anthropometric measurements, fasting and postprandial blood glucose, fasting insulin, and lipid profiles were measured. The VAI and HOMA-IR were calculated. Participants were divided into 4 groups according to the HOMA-IR level, and the correlation between the VAI and HOMA-IR was analyzed. The VAI gradually increased across the HOMA-IR quartiles ( P < .05), and a Pearson correlation analysis showed that VAI was positively related to the HOMA-IR ( P < .001) in males and females. After adjusting for the other covariates, VAI was independently correlated with the HOMA-IR. A logistic regression analysis indicated that VAI elevation was the main risk factor for the increased HOMA-IR in both genders. Overall, the VAI was closely correlated with the HOMA-IR in a population without central obesity.

Visceral adiposity index as a useful tool for the assessment of cardiometabolic disease risk in women aged 65 to 74

“…The VAI was developed as an easy measurable indicator of visceral fat distribution and function . Subsequent studies confirmed its correlation with visceral fat distribution and insulin resistance, in addition also in patients with a normal WC and in those with polycystic ovary syndrome . In one of these studies, VAI showed an equally strong association with VAT accumulation as BMI and WC, while in another study both BMI and WC demonstrated a stronger relationship with VAT than VAI …”

“…1 Subsequent studies confirmed its correlation with visceral fat distribution and insulin resistance, in addition also in patients with a normal WC and in those with polycystic ovary syndrome. [8][9][10][11][12][13] In one of these studies, VAI showed an equally strong association with VAT accumulation as BMI and WC, 8 while in another study both BMI and WC demonstrated a stronger relationship with VAT than VAI. 10 Associations between VAI and clinical or subclinical manifestations of cardiovascular disease (CVD) have been found in several studies.…”

Association between coronary atherosclerosis and visceral adiposity index

“…Several studies showed that VAI is a predictor of incident hypertension [9]. Ji et al reported that VAI has a strong correlation with insulin resistance even in a population without central obesity [10].…”

The association of the visceral adiposity index with insulin resistance and beta-cell function in Korean adults with and without type 2 diabetes mellitus

“…In previous studies on the relationship between VAI and HOMA-IR, Randrianarisoa et al reported that VAI is positively associated with HOMA-IR in nondiabetic German (β = 0.42, p < 0.0001) [23]. Ji et al found that a very high VAI is the main risk factor for increased HOMA-IR in Chinese adults [24]. In the Framingham Heart Study, Preis et al reported that visceral adipose tissue and abdominal subcutaneous adipose tissue are positive correlates with insulin resistance and that visceral adipose tissue is a stronger correlate with insulin resistance than abdominal subcutaneous adipose tissue [25].…”