Association Between the Types of Posterior Staphyloma and Their Risk Factors in Pathological Myopia

An, Guangqi; Dai, Fangfang; Wang, Rui; Liu, Zhenhui; Guo, Ju; Pan, Meng; Jin, Xuemin

doi:10.1167/tvst.10.4.5

Cited by 8 publications

(23 citation statements)

References 36 publications

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“…Our results revealed that the location of RS was related to the shape of the staphyloma, and the retinoschisis was commonly seen in the macula if the staphyloma was type I or type II. This result was consistent with the data from a recent study (An et al, 2021). Several studies have indicated that MTM is more likely to occur and transform into severe stages in eyes with higher PSH (Jo et al, 2012; Ohsugi et al, 2019; Park et al, 2019).…”

Section: Discussionsupporting

confidence: 94%

Clinical characteristics and risk factors of myopic retinoschisis in an elderly high myopia population

Zhou

et al. 2022

Acta Ophthalmologica

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Purpose To investigate the clinical characteristics, internal correlations and risk factors for different locations of retinoschisis (RS) in an elderly high myopia (HM) population. Methods A total of 448 eyes (304 participants) were analysed and classified into no retinoschisis (no‐RS), paravascular retinoschisis (PVRS), peripapillary retinoschisis (PPRS) and macular retinoschisis (MRS) groups. Each participant underwent comprehensive ophthalmic examinations, and posterior scleral height (PSH) was measured in swept‐source optical coherence tomography images. PSH, vitreoretinal interface abnormities and myopic atrophy maculopathy (MAM) were compared among groups. Results Retinoschisis was found in 195 (43.5%) eyes, among which 170 (37.9%) had PVRS, 123 (27.5%) had PPRS, and 103 (23.0%) had MRS. MRS was found to be combined with PVRS in 96 of 103 (93.2%) eyes. MAM was one of the risk factors for RS (odds ratio [OR], 2.459; p = 0.005). Higher nasal PSH was the only risk factor for PVRS (OR, 9.103; p = 0.008 per 1‐mm increase). Elongation of axial length (AL) (OR, 1.891; p < 0.001 per 1‐mm increase), higher PSH in nasal (OR, 5.059; p = 0.009 per 1‐mm increase) and temporal (OR, 13.021; p = 0.012 per 1‐mm increase), epiretinal membrane (ERM; OR, 2.841; p = 0.008) and vitreomacular traction (VMT; OR, 7.335; p = 0.002) were risk factors for MRS. Conclusions Paravascular retinoschisis is the most common type of RS in HM and MRS is mostly combined with PVRS. MAM is one of the risk factors for RS. In addition to longer AL and higher PSH, the presence of VMT and ERM also play an important role in the formation of MRS.

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Section: Discussionsupporting

confidence: 94%

Clinical characteristics and risk factors of myopic retinoschisis in an elderly high myopia population

Zhou

et al. 2022

Acta Ophthalmologica

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“…However, its prevalence found by Curtin (7 eyes, 1.5%) 12 and Ohno-Matsui et al (5 eyes, 2.5%) 17 is lower than in recent series: 4.3%–6.9%. 23 , 25 , 28 Using multimodal imaging, including UWF fundus photos, PPS was even the most common subtype in Moreno et al series (62 eyes, 20%). 22 …”

Section: Background Definition Prevalencementioning

confidence: 89%

“…PS is mostly bilateral 22 , 25 and both eyes of bilateral cases have essentially the same ocular shape 10 , 12 , and PS subtype. 10 , 22 , 25 , 29 Moreno et al found that bilateral cases had longer AL and more severe PM than unilateral cases. 22 In unilateral cases, the AL-difference between the two eyes of the subjects was larger.…”

Section: Background Definition Prevalencementioning

confidence: 98%

“…Types I and II were the most predominant, accounting for 55–74% and 8–26.7% of PS eyes respectively. 12 , 25 PPS, has also suffered from the lack of diagnostic accuracy and has been considered as relatively rare. However, its prevalence found by Curtin (7 eyes, 1.5%) 12 and Ohno-Matsui et al (5 eyes, 2.5%) 17 is lower than in recent series: 4.3%–6.9%.…”

Section: Background Definition Prevalencementioning

confidence: 99%

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Understanding Posterior Staphyloma in Pathologic Myopia: Current Overview, New Input, and Perspectives

Ehongo

2023

OPTH

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Posterior staphyloma (PS) is considered the hallmark of pathologic myopia and is defined as an outpouching of a circumscribed portion of the eyeball with a radius of curvature smaller than that of the adjacent zone. Although more common in eyes with high myopia, it can affect those without it. The presence of PS is associated with a structurally and functionally worse course of high myopia that can lead to visual disability. Unfortunately, the pathogenesis of PS is unclear so far. Thus, due to the increasing prevalence of myopia which has been further exacerbated by the advent of COVID-19 lockdown, researchers are eager to elucidate the pathogenesis of pathologic myopia and that of its complications, especially PS, which will allow the development of preventive strategies. The aim of this work was to review the morphological characteristics of PS with emphasis on similarities with peripapillary staphyloma and to discuss the pathogenesis of PS considering recent suggestions about that of peripapillary staphyloma.

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“…Different types of PS can cause retinal lesions in different parts, resulting in varying degrees of vision or visual field loss ( Ohno-Matsui, 2014 ; Verkicharla et al, 2015 ; An et al, 2021 ; Lee et al, 2021 ). Many researchers have tried to propose a classification method for PS.…”

Section: Discussionmentioning

confidence: 99%

Quantifying the morphology of eyeballs with posterior staphyloma with Zernike polynomials

Hua

Liu

et al. 2023

Front. Bioeng. Biotechnol.

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Purpose: To quantify the morphology of eyeballs with posterior staphyloma (PS) with Zernike decomposition and to explore the association between Zernike coefficients with existing PS classification.Methods: Fifty-three eyes with high myopia (HM, ≤-6.00D) and 30 with PS were included. PS was classified with traditional methods based on OCT findings. Eyeballs’ morphology was obtained with 3D MRI, from which the height map of the posterior surface was extracted. Zernike decomposition was performed to derive the coefficients of the 1st-27th items, which were compared between HM and PS eyes with the Mann-Whitney-U test. Receiver operating characteristics (ROC) analysis was used to test the effectiveness of using Zernike coefficients to discriminate PS from HM.Results: Compared to HM eyeballs, PS eyeballs had significantly increased vertical and horizontal tilt, oblique astigmatism, defocus, vertical and horizontal coma, and higher order aberrations (HOA) (all Ps < 0.05). HOA was the most effective in PS classification with an area under the ROC curve (AUROC) value of 0.977. Among the 30 PS, 19 were the wide macular type with large defocus and negative spherical aberration; 4 were the narrow macular type with positive spherical aberration; 3 were inferior PS with greater vertical tilt, and 4were peripapillary PS with larger horizontal tilt.Conclusion: PS eyes have significantly increased Zernike coefficients, and HOA is the most effective parameter to differentiate PS from HM. The geometrical meaning of the Zernike components showed great accordance with PS classification.

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Association Between the Types of Posterior Staphyloma and Their Risk Factors in Pathological Myopia

Cited by 8 publications

References 36 publications

Clinical characteristics and risk factors of myopic retinoschisis in an elderly high myopia population

Clinical characteristics and risk factors of myopic retinoschisis in an elderly high myopia population

Understanding Posterior Staphyloma in Pathologic Myopia: Current Overview, New Input, and Perspectives

Quantifying the morphology of eyeballs with posterior staphyloma with Zernike polynomials

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