Association between the triglyceride–glucose index and left ventricular global longitudinal strain in patients with coronary heart disease in Jilin Province, China: a cross-sectional study

Abstract

Background This study aimed to investigate the association between the triglyceride–glucose (TyG) index and left ventricular global longitudinal strain (GLS) in patients with coronary heart disease and to examine the role of left ventricular GLS in detecting early changes in cardiac function in patients with coronary heart disease in the subclinical stage. Methods A cross-sectional study involving 178 participants with symptomatic coronary artery disease excluding myocardial infarction or left ventricular dysfunction was conducted in Jilin Province, China. Basic clinical, biochemical, and echocardiographic data were obtained from all participants. Myocardial strain parameters were compared between patients with higher TyG index and those with lower TyG index, and the association between the gradually elevated TyG index and on subclinical cardiac function in patients with coronary heart disease was evaluated. Results The GLS of left ventricle was lower in the higher TyG index group than in the lower TyG index group. As the TyG index increases, the GLS progressively decreases. The results remained stable after adjusting for confounding factors. Conclusions A higher TyG index maybe independently associated with subclinical left ventricular dysfunction in patients with coronary heart disease.

Correlation between the triglyceride-glucose index and left ventricular global longitudinal strain in patients with chronic heart failure: a cross-sectional study

“…Similarly, Huang et al showed that elevated baseline and long-term TyG index levels were significantly linked to an increased risk of adverse LV remodeling, LV dysfunction and an increased risk of HF in a US community population without HF and CAD [ 22 ]. Additionally, a cross-sectional study confirmed an independent association between elevated TyG index and reduced GLS in patients with CAD, suggesting a potential association between the TyG index and subclinical left ventricular dysfunction in CAD patients [ 28 ].…”

“…Previous studies have found that the TyG index may play an essential role in the impairment of left ventricular structure and function [ 22 , 23 ] and is associated with the development of HF and poor prognosis [ 24 – 27 ]. Na et al reported an independent association between the higher TyG index and reduced GLS in patients with coronary artery disease (CAD) [ 28 ].…”

Association between the triglyceride-glucose index and subclinical left ventricular systolic dysfunction in obese patients

“…Recent studies have widely used the TyG index as a marker of insulin resistance. A higher TyG index may be independently associated with subclinical LV dysfunction in patients with coronary heart disease [ 6 ] or acute coronary syndrome [ 20 ] and is likely to be associated with a greater risk of arterial stiffness [ 21 ] or carotid atherosclerosis progression [ 22 ]. Selvi NMK et al reported that the TyG index can be used as a simple and inexpensive alternative for assessing glycaemic control in patients with diabetes [ 23 ].…”

“…Insulin resistance is a pathological-physiological state characterized by decreased insulin sensitivity in peripheral tissues [ 5 ]. The triglyceride–glucose (TyG) index, calculated as Ln (fasting TG [mg/dL] × fasting glucose [mg/dL]/2), has emerged as a new and credible indicator of insulin resistance, and some studies have indicated that the TyG index is associated with coronary artery disease [ 6 ], chronic kidney disease [ 7 , 8 ], hypertension [ 9 ], T2DM [ 10 ], atrial fibrillation [ 11 ], etc.…”