Association between the TP53 codon 72 polymorphism and risk of oral squamous cell carcinoma in Asians: a meta-analysis

Abstract

BackgroundSeveral epidemiological studies have previously investigated the association between the TP53 codon 72 polymorphism and oral squamous cell carcinoma (OSCC) susceptibility; however, current results are inconsistent. We therefore performed this meta-analysis to thoroughly investigate any association among Asian patients.MethodsA comprehensive search of PubMed and Embase databases was performed up to December 2013. We only considered studies consisting of patients diagnosed with OSCC by pathological methods. Statistical analyses were performed using Review Manager (RevMan) 5.2 software and odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association.ResultsA total of 11 case–control studies involving 2,298 OSCC patients and 2,111 controls were included. We found no association between the TP53 codon 72 polymorphism and OSCC susceptibility [(OR = 0.77, 95% CI = 0.48–1.22) for Arg vs. Pro; (OR = 0.67, 95% CI = 0.31–1.43) ArgArg vs. ProPro; (OR = 1.14, 95% CI = 0.97–1.35) ArgPro vs. ProPro; (OR = 0.85, 95% CI = 0.53–1.34) (ArgPro + ArgArg) vs. ProPro; or (OR = 0.34, 95% CI = 0.34–1.23) for ArgArg vs. (ProPro + ArgPro)]. However, subgroup analysis demonstrated an association between the TP53 codon 72 polymorphism and human papillomavirus (HPV)-related OSCC patients. Although statistical heterogeneity was detected, there was no evidence of publication bias.ConclusionsCurrent results suggest that the TP53 codon 72 polymorphism is not associated with OSCC in Asians without the presence of HPV infection. Further research is necessary to determine if such a relationship exists in HPV-related OSCC patients.

Genetic polymorphisms and HPV infection in oral squamous cell carcinomas

“…A common single nucleotide polymorphism (SNP) of p53 at codon 72 in exon 4 results in a substitution of Pro for Arg in the transactivation domain [26]. The common Arg variant allele may alter the susceptibility of p53 to oncogenic HPV E6-mediated degradation [27], and this allele has been associated with oncogenic HPV infection [28,29,30 ]. Furthermore, in case-control analyses, the homozygous Arg/Arg genotype has been significantly associated with an increased risk of HPV-associated cancer [27,31].…”

Human Papillomavirus 16 Physical Status and the <b><i>TP53</i></b> Codon 72 Polymorphism in Japanese HPV-Positive Oropharyngeal Cancer Patients

“…A meta-analysis by Zeng et al [25] reported that the TP53 polymorphism is not associated with HPV-negative oral squamous cell carcinoma in Asians, and they also reported that a subgroup analysis demonstrated an association between TP53 polymorphisms and HPV-associated oral squamous cell carcinoma.…”

Knocking down of p53 triggers apoptosis and autophagy, concomitantly with inhibition of migration on SSC-4 oral squamous carcinoma cells

“…The tumor protein p53 (TP53) is a frequently mutated gene in human cancers, once mutated gains oncogenic role [2][3][4]. Metaphorically speaking, when the guardian of the genome TP53 fails, it leads to the activation of the early carcinogenic events [5].…”