Association between the TAPSE to PASP ratio and short-term outcome in patients with light-chain cardiac amyloidosis

Yu, Fangcong; Cui, Yawei; Shi, Jiaran; Wang, Longbo; Zhou, Yunping; Ye, Tianxin; Ye, Zhehao; Yang, Jin; Wang, Xingxiang

doi:10.1016/j.ijcard.2023.05.058

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…In this cohort, the time-dependent ROC and the AUC showed that the TAPSE/PASP ratio was a better predictor of short-term outcome than TAPSE or PASP. 28 On the other hand, in a previous study including 906 patients with ATTR-CA, TAPSE/PASP ratio was not significantly associated with the risk of all-cause death. 29 We found that TAPSE/PASP ratio was associated with outcome in both ALand ATTR-CA patients, though the prognostic impact of TAPSE/ PASP ratio was even more evident in AL-CA patients.…”

Section: Discussionmentioning

confidence: 80%

Right ventricular to pulmonary artery coupling and outcome in patients with cardiac amyloidosis

Tomasoni,

Adamo,

Porcari

et al. 2023

European Heart Journal - Cardiovascular Imaging

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Aims To investigate the prognostic value of the right ventricle-to-pulmonary artery (RV-PA) coupling in patients with either transthyretin (ATTR) or immunoglobulin light-chain (AL) cardiac amyloidosis (CA). Methods and results Overall, 283 patients with CA from 3 Italian high-volume centres were included (median age 76 years; 63% males; 53% with ATTR-CA, 47% with AL-CA). The RV-PA coupling was evaluated through tricuspid annular plane systolic excursion/pulmonary artery systolic pressure (TAPSE/PASP) ratio. The median value of TAPSE/PASP was 0.45 (0.33-0.63) mm/mmHg. Patients with a TAPSE/PASP ratio <0.45 were older, had lower systolic blood pressure, more severe symptoms, higher cardiac troponin and NT-proBNP levels, greater left ventricular (LV) thickness, and worse LV systolic and diastolic function. A TAPSE/PASP ratio <0.45 was independently associated with a higher risk of all-cause death or HF hospitalization (hazard ratio [HR], 1.98; 95% confidence interval [CI], 1.32-2.96; p = 0.001) and all-cause death (HR 2.18; 95% CI, 1.31-3.62; p = 0.003). The TAPSE/PASP ratio reclassified the risk of both endpoints (net reclassification index 0.46 [95%CI 0.18-0.74], p = 0.001, and 0.49 [0.22-0.77] p < 0.001, respectively), while TAPSE or PASP alone did not (all p > 0.05). The prognostic impact of TAPSE/PASP ratio was significant both in AL-CA patients (HR for the composite endpoint 2.47, 95% CI 1.58-3.85; p < 0.001) and in ATTR-CA (HR 1.81, 95% CI 1.11-2.95; p = 0.017). Receiver operating characteristic curve showed that the optimal cut-off for predicting prognosis was 0.47 mm/mmHg. Conclusion In patients with CA, RV-PA coupling predicted the risk of mortality or HF hospitalization. TAPSE/PASP ratio had a better performance than TAPSE or PASP in predicting prognosis.

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Section: Discussionmentioning

confidence: 80%