Association between the systemic immune‐inflammation index and outcomes among atrial fibrillation patients with diabetes undergoing radiofrequency catheter ablation

Abstract

PurposeTo investigate the relationship between the incidence of atrial fibrillation (AF) recurrence and the levels of the systemic immune‐inflammatory index (SII, platelet × neutrophil/lymphocyte ratio) in patients with AF and diabetes mellitus (DM) undergoing after radiofrequency catheter ablation (RFCA).Patients and MethodsPreoperative SII levels were determined in AF patients with DM undergoing RFCA. Restricted cubic splines were used to determine the correlation between SII and the risk of AF recurrence. Multivariate‐adjusted logistic regression models were constructed to determine the relationship between SII levels and AF recurrence. The predictive value of the clinical model and combined with the SII index was estimated by the area under the receiver‑operating characteristic curve, net reclassification improvement (NRI), and integrated discrimination improvement (IDI).ResultsA total of 204 patients with AF and DM who underwent RFCA in our hospital were included. Seventy‐seven patients had AF recurred during a mean follow‐up of 20 months. Restricted cubic spline analysis showed that when SII ≥ 444.77 × 109/L, there was a positive correlation with the incidence of AF recurrence. In addition, adding the SII to the predictive model for AF recurrence after RFCA in patients with DM and AF could contribute to an increase in C‐statistics (0.798 vs. 0.749, p = .034). After SII was incorporated into the clinical model, the comprehensive discrimination and net reclassification tended to improve (IDI and NRI > 0, p < .05).ConclusionSII was independently and positively associated with recurrence after the first catheter ablation in patients with DM and AF.

Atrial fibrillation recurrence after catheter ablation is associated with RAD51 and p63 proteins

“…The prevalence of repeated ablations was higher in the HIV-positive group of patients with the substrate or non-pulmonary vein triggers of AF (93.5 % vs. 54 %, p < 0.001) [ 25 ]. These observations are consistent with independent and positive associations of systemic immune or inflammatory indices (e.g., platelet × neutrophil/lymphocyte ratio) with AF recurrence after the initial catheter ablation in patients with diabetes [ 26 ].…”

Platelet-to-Lymphocyte Ratio Improves the Predictive Ability of the Risk Score for Atrial Fibrillation Recurrence After Radiofrequency Ablation

“…19 Nevertheless, our study is the first to demonstrate the risk stratification potential of the PLR for AF recurrence using tripartite data. In the clinical setting, our findings and those of other studies 20,21 support the use of the PLR as a risk stratification metric to identify patients suitable for catheter ablation. We also determined the predictive value of the PLR for the recurrence of different AF types.…”