Association between the Serum Metabolic Profile and Lung Function in Chronic Obstructive Pulmonary Disease

Abstract

OBJECTIVES:Although dietary patterns are known to modulate disease severity in patients with chronic obstructive pulmonary disease (COPD), the relationship between the circulating lipid profile and lung function in COPD has not been studied extensively. MATERIAL AND METHODS:There were 43 COPD patients with a history of smoking and 39 patients with a history of biomass fuel exposure recruited in this study, along with 43 age-matched healthy controls. All participants underwent complete lung function profiling, and their glucose and lipid profiles were measured. The association between the metabolic profile and lung function was assessed using the Spearman's rank-order correlation coefficient. RESULTS:52.4% of the COPD patients were smokers compared to the healthy group (46.5%). We found an inverse correlation between triglyceride and functional residual capacity (p=-0.21, p=0.05) and a positive association between serum cholesterol and overall airway resistance (R5) (p=0.24, p=0.04) and central airway resistance (R20) (p=0.32, p=0.004). Low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) ratio and LDL/HDL ratio were also found to correlate with R5 (p=0.25, 0.23, and 0.22, respectively) and R20 (p=0.31, 0.24, and 0.24, respectively). No significant association was observed between other metabolites and either spirometric or plethysmographic lung function indices. CONCLUSION:High serum triglyceride and cholesterol may increase the resistance in the airways, which may lead to increased airway obstruction. Therefore, monitoring of lipid profile should be considered in the diagnosis and management of COPD.

Association between chronic obstructive pulmonary disease and serum lipid levels: a meta-analysis

“…The characteristics of the included studies are summarized in Table 1 . The publication dates of the 11 included studies ranged from 1981 to 2018 [ 13 – 23 ]. The included studies had been performed in Turkey, Bangladesh, China, Canada, Italy, United States, and India.…”

Egg and cholesterol consumption and mortality from cardiovascular and different causes in the United States: A population-based cohort study

“…In addition, we detected adverse associations with risk of death from RD. A cross-sectional study reported that serum cholesterol level was positively associated with airway resistance in patients with chronic obstructive pulmonary disease [44]. In a murine model of asthma, dietary cholesterol enhanced pulmonary allergic inflammation [45].…”

Reference values of impulse oscillometry (IOS) for healthy Indian adults

“…Based on an a priori evidence of the standard deviation of airway resistance values at 5Hz (R5Hz) of 0.07 kPaL -1 Sec -1 in healthy Indians, 3 with a precision of 5%, an alpha risk of 0.05, and an anticipated non-cooperation rate of 15%, we estimated a total sample size of 202 (101 for each gender). We recruited non-smoking healthy volunteers aged between 18 and 88 years with no clinical history of asthma, COPD, emphysema, allergic rhinitis, respiratory tuberculosis, respiratory infections within four weeks of testing, chest deformity (as observed by chest x-ray); cardiovascular disease; obesity (body mass index >30kg/m 2 ), hospitalization in the last 6 months, pregnancy, or concomitant drug therapy affecting muscarinic and adrenergic receptors.…”