Association between the rs12255372 variant of the TCF7L2 gene and obesity in a Cameroonian population

Ngwa, Elvis Ndonwi; Sobngwi, Eugène; Atogho-Tiedeu, Barbara; Noubiap, Jean Jacques; Donfack, Olivier Sontsa; Guewo-Fokeng, Magellan; Mofo, Edith Pascale Mato; Fosso, Priscille Pokam; Djahmeni, E.; Djokam-Dadjeu, Rosine; Evehe, Marie-Solange; Aminkeng, Folefac; Mbacham, Wilfred Fon; Mbanya, Jean Claude

doi:10.1186/s13104-015-1661-3

Cited by 10 publications

(7 citation statements)

References 27 publications

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“…[ 9 , 10 ] In humans, this protein is encoded by the TCF7L2 gene. [ 11 ] Human TCF7L2 gene spans a 215,863 bases region on chromosome 10q25.3, containing 17 exons and encoding 596 amino acids. TCF7L2 gene is first identified as a diabetes risk conferring gene in 2006, [ 12 ] and a number of polymorphic loci have been identified.…”

Section: Introductionmentioning

confidence: 99%

Associations of TCF7L2 gene polymorphisms with the risk of diabetic nephropathy

Zhuang¹,

Niu²,

Liu³

et al. 2018

Medicine

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The aim of the study was to explore the correlation between rs7903146 and rs290487 polymorphisms in transcription factor 7-like 2 (TCF7L2) gene and diabetic nephropathy (DN) in Chinese Han population.Polymerase chain reaction–restriction fragment length polymorphism was used to determine genotypes of TCF7L2 polymorphisms in 90 patients with DN and 96 diabetes patients without DN. The linkage disequilibrium (LD) and haplotype analysis were performed with haploview software. Hardy–Weinberg equilibrium was assessed in the control group based on the genotype distributions of TCF7L2 polymorphisms. The genotype, allele, and haplotype distribution differences between the case and control groups were analyzed by chi-squared test, and odds ratio (OR) and 95% confidence interval (CI) were used to indicate the relative risk of DN.People carrying TT genotype of rs7903146 were more easily to be attacked by DN than CC genotype carriers (P = .02, OR = 4.26, 95% CI = 1.12–16.24). Meanwhile, T allele also showed 1.85 times risk to suffer from DN compared with C allele (OR = 1.85, 95% CI = 1.02–3.10). However, there was no significant difference in genotypes and alleles frequencies of rs290487 between 2 groups. The strong LD existed between the 2 single nucleotide polymorphisms and haplotype T–T (rs7903146–rs290487) increased the susceptibility to DN (OR = 2.63, 95% CI = 1.31–5.25).TCF7L2 rs7903146 polymorphism may be associated with the susceptibility to DN in Chinese Han population, but rs290487 is not. Additionally, haplotype is also a risk factor for DN.

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Section: Introductionmentioning

confidence: 99%

Associations of TCF7L2 gene polymorphisms with the risk of diabetic nephropathy

Zhuang¹,

Niu²,

Liu³

et al. 2018

Medicine

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“… 9 Regarding TCF7L2 polymorphism, there was a study showing an absence of the association between rs12255372 variant and obesity in the Cameroonian population, as well as the European and American populations. 16 Another study in a European population indicated that the TCF7L2 rs7903146 T allele was known to be a risk factor for type 2 diabetes, but not obesity. 28 A meta-analysis about TCF7L2 rs11196218 suggested that there was an association between rs11196218 polymorphism and type 2 diabetes mellitus in the Asian population.…”

Section: Discussionmentioning

confidence: 99%

“…15 Considering the strong connection between type 2 diabetes and obesity, the possible association between TCF7L2 and obesity has been explored. 16 , 17 GLP1-R encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 ( GLP-1 ) hormone, which stimulates glucose-induced insulin secretion. GLP1-R polymorphisms are associated with diabetes, while the associations between GLP1-R polymorphisms and obesity in different countries and ethnic groups vary a lot.…”

Section: Introductionmentioning

confidence: 99%

Associations of TCF7L2 rs11196218 (A/G) and GLP-1R rs761386 (C/T) Gene Polymorphisms with Obesity in Chinese Population

Liu

et al. 2021

DMSO

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Introduction This study aimed to investigate the genetic polymorphism associations with obesity of the transcription factor 7-like 2 ( TCF7L2 ) gene rs11196218 (A/G) and glucagon-like peptide 1 receptor ( GLP1-R ) gene rs761386 (C/T) in the Chinese population. Patients and Methods This was a case–control pilot study involving 60 patients with obesity and 69 non-obesity Chinese adults, and the two groups were sex and age matched. Anthropometric indices of obesity, fasting blood glucose, blood pressure, and blood lipids were assessed. Both polymorphisms were genotyped using matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF). Results There were significant differences in the allelic frequencies of the TCF7L2 rs11196218 and GLP1-R rs761386 between obesity and non-obesity groups (P = 0.003, OR = 2.32, 95% CI [1.31~4.09]; P = 0.034, OR = 1.94, 95% CI [1.05~3.60], respectively). In allele model, the genotypic frequencies of TCF7L2 rs11196218 and GLP1-R rs761386 also differed between obesity and non-obesity groups (P = 0.014 and 0.033, respectively). In dominant model, the TCF7L2 rs11196218 A-carrier (AA/AG) had a higher risk of obesity than GG genotype (P = 0.014, OR = 2.54, 95% CI [1.21~5.35]). Comparison of clinical and biochemical parameters between genotypes showed no significant difference. Conclusion These findings suggest that the rs11196218 (A/G) polymorphism of the TCF7L2 gene and the rs761386 (C/T) polymorphism of the GLP1-R gene were associated with obesity in the Chinese population.

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“…Notably, some key genetic factors were associated with breast, cervical, oesophageal and prostate cancer which are the most common cancers in Africa [13][14][15]. Moreover, the rs12255372 variant of TCF7L2 was also associated with obesity in Cameroonians [16]. The majority of these early studies used genetic variants associated with NCDs in European and Asian populations that were limited by the differences in allele frequencies and LD pattern in Africans.…”

Section: Candidate Gene Studiesmentioning

confidence: 99%

Non-communicable diseases pandemic and precision medicine: Is Africa ready?

et al. 2021

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Non-communicable diseases (NCDs) kill more than 41 million people every year, accounting for 71% of all deaths globally. The prevalence of NCDs is estimated to be higher than that of infectious diseases in Africa by 2030. Precision medicine may help with early identification of cases, resulting in timely prevention and improvement in the efficacy of treatments. However, Africa has been lagging behind in genetic research, a key component of the precision medicine initiative. A number of genomic research initiatives which could lead to translational genomics are emerging on the African continent which includes the Non-communicable Diseases Genetic Heritage Study (NCDGHS) and the Men of African Descent and Carcinoma of the Prostate (MADCaP) Network. These offer a promise that precision medicine can be applied in African countries. This review evaluates the advances of genetic studies for cancer, hypertension, type 2 diabetes and body mass index (BMI) in Africa.

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Association between the rs12255372 variant of the TCF7L2 gene and obesity in a Cameroonian population

Cited by 10 publications

References 27 publications

Associations of TCF7L2 gene polymorphisms with the risk of diabetic nephropathy

Associations of TCF7L2 gene polymorphisms with the risk of diabetic nephropathy

Associations of TCF7L2 rs11196218 (A/G) and GLP-1R rs761386 (C/T) Gene Polymorphisms with Obesity in Chinese Population

Non-communicable diseases pandemic and precision medicine: Is Africa ready?

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