Association between the rs1143634 polymorphism in interleukin-1B and chronic periodontitis: Results from a meta-analysis composed by 54 case/control studies

Silva, Felipe Rodolfo Pereira da; Vasconcelos, Any Carolina Cardoso Guimarães; França, Luíz Felipe de Carvalho; Lenardo, David Di; Nascimento, Hélio Mateus Silva; Vasconcelos, Daniel Fernando Pereira

doi:10.1016/j.gene.2018.05.067

Cited by 30 publications

(34 citation statements)

References 67 publications

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“…22 Recent meta-analyses demonstrated that the IL-1β rs1143634 polymorphism is associated with periodontitis. 23,24 Individuals with IL-1β rs1143634 also show high levels of IL-1β in the GCF, 25 which adds to the evidence that IL-1β rs1143634 might be a genetic risk factor for periodontitis.…”

Section: Clinical Evidence Regarding Interleukin(il)-1βmentioning

confidence: 95%

Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review

et al. 2020

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Interleukin(IL)-1β, a pro-inflammatory cytokine, was elevated and participates in periodontitis. Not only the link between IL-1β and periodontitis was proved by clinical evidence, but also the increased IL-1β triggers a series of inflammatory reactions and promotes bone resorption. Currently, IL-1β blockage has been therapeutic strategies for autoimmune and autoinflammatory diseases such as rheumatoid arthritis, cryopyrin-associated periodic syndromes, gout and type II diabetes mellitus. It is speculated that IL-1β be a potential therapeutic target for periodontitis. The review focuses on the production, mechanism, present treatments and future potential strategies for IL-1β in periodontitis.

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Section: Clinical Evidence Regarding Interleukin(il)-1βmentioning

confidence: 95%

Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review

et al. 2020

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“…In the last decades, some polymorphisms mainly in genes related to the immune response and bone remodeling have been preferentially chosen in many candidate gene studies. [12][13][14] Indeed, it is notable in the literature that those genes seemed to be like "classically periodontally investigated polymorphisms," which can be evidenced by the development of many meta-analyses [15][16][17][18] in genes such as (a) (−819 C > T) in the IL-10 gene, which encodes the important anti-inflammatory cytokine 19 ; (b) (−889 G > A) in the IL1A gene, which encodes the IL1-1A cytokine facilitating and amplifying the inflammatory response by induction of adhesion molecules to cellular infiltrate and monocyte stimulation with bone resorption 15 ;…”

Section: Introductionmentioning

confidence: 99%

“…Since then, numerous following studies have shown a high variety of results, which permitted the development of some meta-analyses 12,15. A meta-analysis performed in 2012 that had eligible ten studies with larger samples showed the OR = 1.54 for the association between the rs1143634 IL1B SNP and periodontitis 15.…”

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confidence: 99%

Genetic polymorphisms in the Interleukins IL1B, IL4, and IL6 are associated with concomitant periodontitis and type 2 diabetes mellitus in Brazilian patients

Cirelli

Nepomuceno

Rios

et al. 2020

J of Periodontal Research

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Objective: To assess whether single nucleotide polymorphisms (SNPs) in the IL10, IL1A, IL1B, IL4, TNFA, IL6, OPG, RANK, and RANKL genes, "classically" related with periodontitis, could be associated with susceptibility to T2DM, and also with both diseases concomitantly. Background: There are common pathogenic mechanisms in type 2 diabetes mellitus (T2DM) and periodontitis, but the knowledge of the genetic aspect of this is limited. In patients affected by concomitant T2DM and periodontitis, whose incidence is increasing, there is scarce information regarding the gene-phenotype association, including whether there are genes able to influence both diseases as comorbidities. Methods: Periodontal clinical parameters and biochemical profile (Insulin, Fasting Glycemia, HbA1c, Triglycerides, Total Cholesterol, HDL-cholesterol, and LDLcholesterol) data were obtained from 894 individuals divided into following three groups: Healthy (H; n = 347), Periodontitis (P; n = 348), and Periodontitis + T2DM (P + T2DM; n = 199). DNA from oral epithelial cells was collected for genotyping. Associations between SNPs and pathologies were tested by multiple logistic regression models, adjusting for age, sex, and smoking habits. We also investigated whether there are sex or smoking effects of each SNP in these phenotypes. Results: The rs1143634-GA (IL1B) SNP showed significantly less likely to develop P + T2DM for all population and mainly for women (adjusted OR = 0.37, 95% CI = 0.16-0.88), while women carrying the rs224320 CT (IL4) were more susceptible to develop P + T2DM (adjusted OR = 1.81, 95% CI = 1.04-3.15). Men carrying the rs1800795-CC (IL6) genotype were less likely to develop T2DM (adjusted OR = 0.12, 95% CI = 0.02-0.70, P = .01). Conclusions: Some SNPs in the IL1B, IL4, and IL6 genes demonstrated sex-influenced association with concomitant periodontitis and T2DM, increasing the evidence of a common genetic component between these diseases and contributing with the understanding of their common pathogenic mechanisms. | 919 CIRELLI Et aL.

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“…The inflammatory condition is caused by the accumulation of bacteria around the periodontal tissues, resulting in an over immune-inflammatory response of the organism in which several cytokines, growth factors, enzymes, and inflammatory cells act resulting in periodontal destruction (Junior et al, 2013). Although the bacteria are the initiating agent of periodontitis due to their causing the release of inflammatory mediators (Lee, Lee, Lee, Park, & Kim, 2018), genetic factors of the host predispose to a more intense inflammatory response with greater tissue destruction (da Silva et al, 2016(da Silva et al, , 2018.…”

Section: Introductionmentioning

confidence: 99%

Bromelain reduces the non‐alcoholic fatty liver disease and periodontal damages caused by ligature‐induced periodontitis

Alves¹,

Carvalho²,

Silva

et al. 2020

Oral Diseases

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Objective: The objective of this research was to evaluate the effects of bromelain (derived from Ananas comosus) upon periodontitis in rats. Materials and Methods: Twenty-four rats were separated into groups: control, periodontitis, and bromelain treatment. Bromelain was administered daily by intraperitoneal injection for 20 days. Periodontitis was induced by ligature around the first molars. Oral parameters and blood biomarkers were measured. The histopathological evaluation of the hepatic tissue was performed. Bromelain treatment significantly reduced several oral inflammatory parameters, alveolar bone loss, and blood biomarkers compared to the rats on periodontitis. Results: Treatment with bromelain improved the steatosis score. Bromelain used in ligature-induced periodontitis in rats was able to reduce the oral inflammatory parameters Gingival Bleeding Index (GBI), tooth mobility (TM), probing pocket depth (PPD), malondialdehyde (MDA), alveolar bone height (ABH) and gingival myeloperoxidase (MPO) and blood parameters (cholesterol, triglycerides, alanine aminotransferase, and aspartate aminotransferase). Bromelain treatment reduced the impact of periodontitis, such as the reduction of hepatic steatosis and improvement in the dosages of MDA and GSH. Conclusion: Bromelain acts as a potential adjunct in the non-surgical treatment of periodontitis and, consequently, reduces the impact of periodontitis, acting as antiinflammatory and antioxidant. K E Y W O R D S alveolar bone loss, anti-inflammatory, antioxidant, periodontal diseases, proteinase How to cite this article: Alves EHP, Carvalho ADS, Silva FRP, et al. Bromelain reduces the non-alcoholic fatty liver disease and periodontal damages caused by ligature-induced periodontitis.

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Association between the rs1143634 polymorphism in interleukin-1B and chronic periodontitis: Results from a meta-analysis composed by 54 case/control studies

Cited by 30 publications

References 67 publications

Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review

Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review

Genetic polymorphisms in the Interleukins IL1B, IL4, and IL6 are associated with concomitant periodontitis and type 2 diabetes mellitus in Brazilian patients

Bromelain reduces the non‐alcoholic fatty liver disease and periodontal damages caused by ligature‐induced periodontitis

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