Association between the RETN -420C/G polymorphism and type 2 diabetes mellitus susceptibility: A meta-analysis of 23 studies

Abstract

BackgroundThe published findings on the link between the resistin (RETN) gene polymorphism and type 2 diabetes mellitus (T2DM) risk are still contradictory. Here, through a meta-analysis, we summarized a more precise evaluation of their connection by synthesizing existing research.MethodsPubMed, Google Scholar, and Web of Science were electronically searched, and all cited sources were manually searched. The heterogeneity of effects was tested and all statistical analyses were performed in Stata 12.0.ResultsA total of 23 studies with 10,651 cases and 14,366 controls on RETN -420C/G polymorphism were included. The overall results showed that the association of RETN -420C/G polymorphism and T2DM susceptibility was not significant [for the allelic model: odds ratio (OR) = 0.98, 95% confidence interval (CI) = 0.87–1.10, pheterogeneity <.001; I2 = 84.6%; for the dominant model: OR = 0.96, 95% CI = 0.80–1.15, pheterogeneity <.001; I2 = 87.1%; and for the recessive model: OR = 0.96, 95% CI = 0.82–1.12, pheterogeneity <.001; I2 = 56.9%] but with high heterogeneity across studies (p <.0001). Meta-regression found that the median age of T2DM participants (using age 50 as the cutoff) could be a factor in the observed variation. The RETN -420C/G polymorphism seems to be linked to an increased risk of T2DM in younger individuals [for dominant: OR = 0.84 (95% CI, 0.72–0.98; pheterogeneity <.001; I2 = 80.9%)] and decreased risk in older people [for dominant: OR = 3.14 (95% CI, 2.35–4.19; pheterogeneity = .98; I2 = 0.0%)].ConclusionsCurrent results found no evidence that the RETN -420C/G variant was linked to T2DM susceptibility, but the patient’s age appears to be a potential factor that contributed to high heterogeneity across studies. Additional high-quality and well-designed investigations are required to confirm these results.

Tandem Mass Tag-Based Proteomic Profiling Identifies Biomarkers in Drainage Fluid for Early Detection of Anastomotic Leakage after Rectal Cancer Resection

“…Among the top three DEPs, RETN belongs to a family of RETN-like molecules . Yao et al suggested that RETN was associated with the immune response and the infiltration of the CD8 + T cells and CD4 + T cells .…”

“…However, there are no relevant studies about RETN and CELA3A in the drainage fluid. RETN is a family member of mouse resistin-like genes that displays antibacterial activity in the skin against both Gram-positive and Gram-negative bacteria . Moreover, the expression of RETN was significantly associated with immune cell disorders .…”

“…RETN is a family member of mouse resistin-like genes that displays antibacterial activity in the skin against both Gram-positive and Gram-negative bacteria. 19 Moreover, the expression of RETN was significantly associated with immune cell disorders. 20 Thus, to investigate the influence of RETN on the immune response, we determined whether RETN affected the Jurkat cells' secretion of cytokines.…”

“…Among the top three DEPs, RETN belongs to a family of RETN-like molecules. 19 Yao et al suggested that RETN was associated with the immune response and the infiltration of the CD8 + T cells and CD4 + T cells. 20 Thus, to investigate the influence of RETN on T cell immunity, we examined the effect of RETN on the cytokines secreted by the Jurkat cells.…”

Identification of lysosome-related genes in gastric cancer and development of a prognostic model

“…The RETN gene is capable of encoding resistin and adipokines in the human body, exhibiting risk associations between resistin and RETN with susceptibility to breast cancer and type 2 diabetes mellitus [30][31]. Furthermore, it has been suggested that polymorphisms in RETN may contribute to an increased susceptibility to colon cancer disease [32].…”