Association between the quality of inner cell mass and first trimester miscarriage after single blastocyst transfer

Shi, Dayuan; Xu, Jiawei; Zhang, Meixiang; Niu, Wenbin; Shi, Hao; Yao, Guidong; Li, Ying; Zhang, Nan

doi:10.1186/s12958-020-00595-y

Cited by 20 publications

(18 citation statements)

References 27 publications

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“…In the present study, we found that Group B and FET cycles with Day 6 blastocysts had a significantly higher rate of CPL than Group A and FET cycles with Day 5 blastocysts, respectively. Part of these results was consistent with previous reports that transfer of Day 6 blastocysts resulted in a significantly higher miscarriage rate than that of Day 5 blastocysts (43,44). These results indicated that MA or days of blastocyst could serve as an independent factor affecting the occurrence of CPL.…”

Section: Discussionsupporting

confidence: 92%

“…A recent study reported no statistical correlation between miscarriage and the grade of ICM or TE (43). In that study, they only included blastocysts with grade A or B ICM and without grade C ICM; therefore, it is not strange that no association of ICM grade with miscarriage was observed (43). However, that study showed a trend that the C score of TE was related to a higher rate of miscarriage (43).…”

Section: Discussionmentioning

confidence: 88%

“…Previous studies have investigated the relationship between the quality of TE or ICM and miscarriage; however, no consistent conclusions have been drawn (41,42). A recent study reported no statistical correlation between miscarriage and the grade of ICM or TE (43). In that study, they only included blastocysts with grade A or B ICM and without grade C ICM; therefore, it is not strange that no association of ICM grade with miscarriage was observed (43).…”

Section: Discussionmentioning

confidence: 91%

“…In that study, they only included blastocysts with grade A or B ICM and without grade C ICM; therefore, it is not strange that no association of ICM grade with miscarriage was observed (43). However, that study showed a trend that the C score of TE was related to a higher rate of miscarriage (43). A common drawback of these studies is that they only considered a part of the blastocyst (TE or ICM) and did not take the blastocyst as a whole for analysis.…”

Section: Discussionmentioning

confidence: 99%

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Analysis of Biochemical and Clinical Pregnancy Loss Between Frozen-Thawed Embryo Transfer of Blastocysts and Day 3 Cleavage Embryos in Young Women: A Comprehensive Comparison

et al. 2021

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BackgroundTo determine whether the embryo developmental stage affects biochemical or clinical pregnancy loss in young women undergoing frozen-thawed embryo transfer (FET) and to investigate the underlying mechanism.MethodsThis was a retrospective study including a total of 18,34 β-HCG (human chorionic gonadotropin)-positive FET cycles. According to the morphological appearance (MA) of transferred blastocysts, FET cycles with blastocysts were divided into two groups: Group A: morphologically good (MG) blastocysts only, and Group B: at least one morphologically non-good (MNG) blastocyst. FET cycles with day 3 cleavage embryos were assigned as Group C. Biochemical and clinical pregnancy loss were the main outcome measures.Result(s)We predicted 78% in vivo-formed MG and 53.9% in vivo-formed day 5 blastocysts in Group C. (a) Including cases in Group A and Group B for binary logistic regression, we showed that Group B and day 6 blastocysts had significantly higher rates of BPL and CPL than Group A and day 5 blastocysts, respectively. (b) Including cases in Group A, Group B, and Group C for binary logistic regression, we showed that Group C had a significantly higher rate of BPL than Group A and day 5 blastocysts and a similar rate of BPL as Group B and day 6 blastocysts. Group C had a higher rate of CPL than Group A (p=0.071) and day 5 blastocysts (p=0.039), and a lower rate of CPL than Group B (p=0.199) and day 6 blastocysts (p=0.234).Conclusion(s)(1) MA and days of usable blastocysts could serve as independent factors affecting the occurrence of BPL and CPL. (2) Transfer of day 3 cleavage embryos may produce “unusable blastocysts” in vivo, which significantly increased the rate of BPL. (3) The rate of CPL resulting from the transfer of day 3 embryos may depend on the rate of in vivo-formed MG or day 5 blastocysts. Our study indicated that the difference in the BPL or CPL between transfer of blastocysts and day 3 cleavage embryos may largely depend on the quality of embryos transferred.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Analysis of Biochemical and Clinical Pregnancy Loss Between Frozen-Thawed Embryo Transfer of Blastocysts and Day 3 Cleavage Embryos in Young Women: A Comprehensive Comparison

et al. 2021

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“…As expected, we showed that number of embryos transferred positively while female age adversely affected clinical pregnancy and live birth, indicating the con dence of our data. In line with a recent study (34), transfer of day 6 blastocysts increase the risk of abortion than transfer of day 5 blastocysts. After controlling factors including female or male age, number of embryos transferred, female BMI, semen DFI and days of blastocyst, we found MG blastocysts from the L group showed decreased chance of implantation or live birth, compared to MG blastocysts from the H group.…”

Section: Discussionsupporting

confidence: 88%

Transfer of Cleavage-Stage Embryos May Benefit Normal Responders With Low Rate of Morphologically Good Embryos Formation On Day 3: A Comparison Study

Dai

Xia

Gao

et al. 2021

Preprint

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Background Do morphologically good (MG) embryos from patients with high and low rate of MG embryos on day 3 (RMD3) show similar developmental potential (DP)? Methods This respective study finally included a total of 916 fresh cycles and related 1074 FET cycles from Jan 2017 to May 2020 in our reproductive center. Cycles with high RMD3 were defined as the H group, while cycles with low RMD3 were defined as the L group. The basic characteristics of patients and fresh cycles, blastulation rate, and clinical outcomes were compared between the H and L groups in either ET cycles with MG day 3 cleavage embryos (ETC group) or ET cycles with MG blastocysts (ETB group). Results The overall characteristics of patients and cycles were grossly comparable between the H and L groups either in ETC or ETB groups. In ETB group, useable blastocysts formation rate, implantation rate and live birth rate was significantly reduced in the L group, compared to the H group;In ETC group, useable blastocysts formation rate was significantly reduced in the L group. However, implantation rate and livebirth rate was similar between the L and H groups. Conclusion The in vitro DP of MG day 3 embryos and in vivo DP of MG blastocysts were reduced significantly, while a similar in vivo DP of MG day 3 embryos was observed in patients with low RMD3 as compared to patients with high RMD3. It seems that direct transfer of day 3 MG embryos instead of extended culture may benefit patients with RMD3.

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Laser-assisted hatching improves pregnancy outcomes in frozen-thawed embryo transfer cycles of cleavage-stage embryos: a large retrospective cohort study with propensity score matching

Wei

Xiang

Liu

et al. 2023

J Assist Reprod Genet

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Introduction Laser-assisted hatching (LAH) is a commonly used adjunct technique; however, its effectiveness has not been fully established. Objective We evaluated the effects of LAH on pregnancy outcomes in frozen-thawed embryo transfer (FET) cycles of cleavage-stage embryos. Materials and methods This retrospective study involved 5779 FET cycles performed at the Reproductive and Genetic Center in the Affiliated Hospital of Shandong University of Traditional Chinese Medicine between January 2016 and December 2020. After propensity score matching, 3535 FET cycles were included, out of which 1238 were subjected to LAH while the remaining 2297 cycles were non-LAH (NLAH). The primary outcomes were clinical pregnancy rate (CPR) and live birth rate (LBR) while secondary outcomes included implantation rate (IR), biochemical pregnancy rate (BPR), ectopic pregnancy rate (EPR), pregnancy loss rate (PLR), multiple pregnancy rate (MPL), and monozygotic twinning rate (MTR). Logistic regression analysis was conducted to adjust for possible confounders. Subgroup analysis was also performed based on the endometrial preparation regimen. Results The LAH group exhibited a higher LBR, compared to the NLAH group (34.9% vs. 31.4%, OR = 1.185, 95% CI = 1.023, 1.374, P = 0.024). Additionally, the LAH group showed a decreasing trend in PLR and EPR; however, differences were insignificant (P = 0.078, P = 0.063 respectively). Differences in IR (24.6% vs. 24.3%), BPR (41.8% vs. 40.4%), CPR (40.7% vs. 38.3%), MPR (14.1% vs. 17.3%), and MTR (1.4% vs. 1.1%) were insignificant. Subgroup analysis revealed that LAH may be more conducive for pregnancy outcomes in hormone replacement cycles. Conclusions In summary, LAH has an increased chance of achieving live births. However, further prospective studies should be performed to confirm our findings.

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Association between the quality of inner cell mass and first trimester miscarriage after single blastocyst transfer

Cited by 20 publications

References 27 publications

Analysis of Biochemical and Clinical Pregnancy Loss Between Frozen-Thawed Embryo Transfer of Blastocysts and Day 3 Cleavage Embryos in Young Women: A Comprehensive Comparison

Analysis of Biochemical and Clinical Pregnancy Loss Between Frozen-Thawed Embryo Transfer of Blastocysts and Day 3 Cleavage Embryos in Young Women: A Comprehensive Comparison

Transfer of Cleavage-Stage Embryos May Benefit Normal Responders With Low Rate of Morphologically Good Embryos Formation On Day 3: A Comparison Study

Laser-assisted hatching improves pregnancy outcomes in frozen-thawed embryo transfer cycles of cleavage-stage embryos: a large retrospective cohort study with propensity score matching

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