Association between the Polymorphism of the Fatty acid binding protein 5 (FABP5) Gene within the BTA 14 QTL Region and Carcass/Meat Quality Traits in Hanwoo

허강녕,; 김남국,; Lee, Seung Hwan; 김남영,; 전진태,; 박응우,; 오성종,; 김태헌,; 성환후,; 윤두학,

doi:10.5187/jast.2011.53.4.311

Cited by 3 publications

(1 citation statement)

References 25 publications

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“…The fats present in beef are rich in long‐chain polyunsaturated fatty acids, which participate in several biological processes relevant to human health (Alex et al., 2011). Among the genes found in the processes related to lipids metabolism, FABP5 and DGAT2 genes, highlighted in the tag cloud (Figure 4c), are frequently associated with the meat quality of beef cattle (Dunner et al., 2013; Heo et al., 2011; Leal‐Gutiérrez et al., 2020; Sheng et al., 2014); both genes function in the triglyceride metabolic process. Lipid metabolism modulation can be controlled by genes that are also highly expressed in macrophages, such as NFKB2 (transcription factor).…”

Section: Discussionmentioning

confidence: 99%

A network‐based approach to understanding gene–biological processes affecting economically important traits of Nelore cattle

Corrêa,

Silva,

dos Santos

et al. 2023

Animal Genetics

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This study aimed to build gene–biological process networks with differentially expressed genes associated with economically important traits of Nelore cattle from 17 previous studies. The genes were clustered into three groups by evaluated traits: group 1, production traits; group 2, carcass traits; and group 3, meat quality traits. For each group, a gene–biological process network analysis was performed with the differentially expressed genes in common. For production traits, 37 genes were found in common, of which 13 genes were enriched for six Gene Ontology (GO) terms; these terms were not functionally grouped. However, the enriched GO terms were related to homeostasis, the development of muscles and the immune system. For carcass traits, four genes were found in common. Thus, it was not possible to functionally group these genes into a network. For meat quality traits, the analysis revealed 222 genes in common. CSRP3 was the only gene differentially expressed in all three groups. Non‐redundant biological terms for clusters of genes were functionally grouped networks, reflecting the cross‐talk between all biological processes and genes involved. Many biological processes and pathways related to muscles, the immune system and lipid metabolism were enriched, such as striated muscle cell development and triglyceride metabolic processes. This study provides insights into the genetic mechanisms of production, carcass and meat quality traits of Nelore cattle. This information is fundamental for a better understanding of the complex traits and could help in planning strategies for the production and selection systems of Nelore cattle.

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