Association between the neutrophil-to-lymphocyte ratio, a new marker of systemic inflammation, and restless legs syndrome

Varım, Ceyhun; Acar, Bilgehan Atılgan; Uyanık, Mehmet Şevki; Acar, Türkan; Alagoz, Neslihan Aybala; Nalbant, Ahmet; Kaya, Tezcan; Ergenç, Hasan

doi:10.11622/smedj.2016154

Cited by 30 publications

(38 citation statements)

References 22 publications

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“…For this purpose, the fasting blood glucose, lipid profile, complete blood count and total testosterone level that are requested by clinicians are among these tests (Burnett, ). Studies conducted on NLR and PLR values, which show the relation between systemic inflammation and many diseases in ED and aetiology, are increasing in the present literature (Furuncuoğlu et al, ; İdil Soylu et al, ; Meng et al, ; Tulgar et al, ; Varım et al, ; Xu et al, ). When we selected our study group, we included not only the pre‐treatment values, but also those who were asked for a CBC for any reason to determine the changes in the 1st month after PDE5i treatment, which is different from previous studies.…”

Section: Discussionmentioning

confidence: 97%

“…In recent years, publications indicating that active inflammatory processes cause ED are increasing. In these studies where neutrophil–lymphocyte (NLR) and platelet–lymphocyte ratios (PLR) were used as signs of inflammation, a significant relationship was found between diseases with these proportions (Furuncuoğlu et al, ; İdil Soylu et al, ; Meng et al, ; Sambel et al, ; Tulgar et al, ; Varım et al, ; Xu et al, ).…”

Section: Introductionmentioning

confidence: 99%

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The effect of using tadalafil 5 mg/day on neutrophil–lymphocyte and platelet–lymphocyte ratios in mild‐medium and severe erectile dysfunction patients; and comparison of clinical response

Demirci

Özgür

2019

Andrologia

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To examine the relation between NLR (neutrophil–lymphocyte ratio) and PLR (platelet–lymphocyte ratio) rates and the severity of ED (erectile dysfunction) and the effect of tadalafil 5 mg/day on these, a total of 143 patients were retrospectively evaluated. Sixty‐three patients with ED who came for follow‐up examinations in the 1st month of the treatment were included as the study group, and 80 men who were not diagnosed with ED were as the control group. The age and Charlson Comorbidity Indexes (CCI) of the study and control groups were compared with the IIEF 5, NLR and PLR values before and after the treatment. The mean age and median CCI were higher in the severe ED group (p < 0.05). The mean NLR and PLR values were lower in the control group (p < 0.001). In the study group, the NLR and PLR values decreased with the increase in the IIEF 5 scores (p < 0.001). The ROC curve was significant for the NLR and PLR scores (AUC = 0.779, [95% CI: 0.698–0.860]; AUC = 0.754, [95% CI: 0.670–0.838] p < 0.001). Although more prospective and randomized studies are needed, the systemic inflammation decreases and the clinical symptoms improve in patients who use tadalafil 5 mg/day.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

The effect of using tadalafil 5 mg/day on neutrophil–lymphocyte and platelet–lymphocyte ratios in mild‐medium and severe erectile dysfunction patients; and comparison of clinical response

Demirci

Özgür

2019

Andrologia

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“…The etiology of the disorder is still not well known (7). It is thought to be caused by dopaminergic dysfunction (8).…”

Section: Introductionmentioning

confidence: 99%

“…The neutrophil-tolymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been used as markers of systemic inflammation recently. NLR and PLR measurements cost less than other inflammatory markers, and it is practical and easy to perform (7,15). In cases of various acute and chronic inflammatory conditions, NLR and PLR were found high in studies, and in the only study which studied NLR in patients with RLS, it was found that NLR was higher in the study group (7).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Inflammation with Neutrophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratio in Restless Legs Syndrome

Tak¹,

Şengül²

2018

tnd

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Huzursuz bacaklar sendromu (HBS); ekstremitelerde öncelikle bacaklarda hareket ettirme dürtüsü ve anormal duyularla karakterize, kronik, ilerleyici sensorimotor bir bozukluktur. Semptomların başlangıcı gece olsa da hastalık ilerledikçe gün içindeki hareketsiz dönemlerde de görülebilir. Nüfusun %5-15 kadarında görülür. Çalışmamızda HBS patofizyolojisinde enflamatuvar mekanizmaların rolü olabileceği hipotezinden hareketle HBS olan hastalarda nötrofillenfosit oranı (NLR) ve trombosit-lenfosit oranı (PLR) ile sistemik enflamasyonu değerlendirmeyi amaçladık. Gereç ve Yöntem: Toplam 62 HBS hastası ile 40 sağlıklı gönüllü çalışmaya alınarak her iki gruba ait sosyo-demografik özellikler incelendi. Tüm hastaların rutin biyokimya ve hemogram incelemeleri yapıldı. NLR, mutlak nötrofil sayısının lenfosit sayısına bölünmesi ile, PLR ise mutlak trombosit sayısının lenfosit sayısına bölünmesi ile elde edildi. Bulgular: NLR düzeyleri değerlendirildiğinde hasta grubuyla (1,80±1,10) kontrol grubu (2,01±0,67) arasında anlamlı fark saptanmadı (p=0,26). PLR değeri ise; HBS grubunda (104,86±46,52) kontrol grubuna göre yüksek seviyede (97,78±39,09) olmasına rağmen anlamlı değildi (p=0,42). Vitamin B12 ve folat seviyeleri değerlendirildiğinde hasta ve kontrol grupları arasında anlamlı bir fark bulunmadı. Ferritin düzeyleri ise hasta grubunda anlamlı derecede düşüktü (p=0,03). Sonuç: HBS olan hastalarda NLR ve PLR ile birlikte değerlendirildiğinde her iki parametre için anlamlı bir artış olmadığı saptandı. Bu durumun nötrofil, lenfosit ve trombosit sayısı gibi hematolojik parametrelerin çeşitli durumlardan kolayca etkilenebiliyor olmasından ya da hasta sayısının az olmasından kaynaklanabileceğini düşünüyoruz. Gelecekte sistemik enflamasyonu ve nöroenflamasyonu göstermesi muhtemel yeni biyobelirteçlerin saptanması bu duruma açıklık getirecektir. Anahtar Kelimeler: Huzursuz bacaklar sendromu, nötrofil-lenfosit oranı, trombosit-lenfosit oranı Objective: Restless legs syndrome (RLS) is a chronic, progressive sensorimotor disorder characterized by an irresistible urge to move the extremities-especially the legs-and abnormal sensations. Although symptoms are observed during the night at the initial stage of the disease, as the disease progresses, they can be observed at rest during the day. It is seen in 5-15% of the population. We aimed to evaluate the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio and systemic inflammation in patients with RLS based on the hypothesis that inflammatory mechanisms may play a role in the pathophysiology of RLS. Materials and Methods: A total of 62 patients with RLS and 40 healthy volunteers were included in the study and the sociodemographic characteristics of both groups were examined. Routine biochemistry and hemogram studies were performed on all patients. NLR was obtained by dividing the absolute number of neutrophils by the number of lymphocytes and PLR by dividing the absolute platelet count by the lymphocyte count. Results: When the NLR levels were evaluated, no significant differe...

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“…This syndrome was first described in 1945 by Dr. Karl Ekbom. 1 The etiology of RLS has not been elucidated until today. The symptoms increase at night and at rest.…”

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confidence: 99%

Frequency of cardiovascular diseases in the patients with restless legs syndrome

Varım

Acar

et al. 2019

Int J Adv Med

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INTRODUCTIONRestless legs syndrome (RLS) is a sensory-motor neurological disease characterized by discomfort, unpleasant sensations, an urge to move the legs. This syndrome was first described in 1945 by Dr. Karl Ekbom. 1 The etiology of RLS has not been elucidated until today. The symptoms increase at night and at rest. Dysregulation of iron metabolism, dopaminergic dysfunction, genetic predisposition are the most common theories in the etiology of RLS. 2 RLS is divided to two groups named as idiopathic and secondary. Secondary RLS occurs due to conditions or diseases such as hemochromatosis, arthritis, chronic renal failure or pregnancy. Hypertension (HT), non-dipper hypertension, dyslipidemia, obesity, cigarette smoking are independent risk factors for cardiovascular diseases. The association between HT and RLS remains unclear in the literature. ABSTRACTBackground: Restless Legs Syndrome (RLS) is a sensory-motor neurological disease characterized by discomfort, unpleasant sensations, an urge to move the legs. There are a lot of studies showing the association between Restless Legs Syndrome (RLS), Cardiovascular Diseases (CVD), Hypertension (HT) and Body Mass Index (BMI). The potential underlying mechanism of an increased risk of CVD in RLS is not clear but may involve hypertension, as Periodic Limb Movements during Sleep (PLMS) were shown to be related to blood pressure increases. These studies were inconsistent. The aim of this case control study was to show the prevalence of CVD in the patients with RLS compared with a control group. Methods: A total of 37 newly diagnosed patients with RLS (group 1) who were applied to neurology polyclinic of Sakarya University Hospital between March 2016 and May 2017 and 37 control subjects (group 2) were included in this case control study. RLS was diagnosed using the criteria of the International RLS Study Group. Both groups were screened for HT, dyslipidemia, coronary artery diseases, atrial fibrillation. 24hour Ambulatory Blood Pressure Monitoring (ABPM) were enrolled for both groups. Interventricular septum was measured with echocardiography by cardiologist for diagnosis of left ventricular hypertrophy. Results: There were no significant differences in sex (p:0.11) and age (p:0.33) between the two groups. Hypertension (p:0.001) and non-dipper hypertension (p:0.004), BMI (p:0.004), left ventricular hypertrophy (p:0,002) were found statistically significantly higher than the control group. There were no differences in atrial fibrillation (p:1) and hyperlipidemia (p:0.69) between two groups. Conclusions: Patients with RLS should be followed closely for cardiovascular diseases.

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Association between the neutrophil-to-lymphocyte ratio, a new marker of systemic inflammation, and restless legs syndrome

Cited by 30 publications

References 22 publications

The effect of using tadalafil 5 mg/day on neutrophil–lymphocyte and platelet–lymphocyte ratios in mild‐medium and severe erectile dysfunction patients; and comparison of clinical response

The effect of using tadalafil 5 mg/day on neutrophil–lymphocyte and platelet–lymphocyte ratios in mild‐medium and severe erectile dysfunction patients; and comparison of clinical response

Evaluation of Inflammation with Neutrophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratio in Restless Legs Syndrome

Frequency of cardiovascular diseases in the patients with restless legs syndrome

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