Association between the Interleukin‐6 Gene −572 C/G Polymorphism and the Risk of Type 2 Diabetes Mellitus: A Meta‐Analysis of 11,681 Subjects

Abstract

SummaryThe association between the interleukin-6 (IL-6) gene −572 C/G (rs1800796) polymorphism and type 2 diabetes mellitus (T2DM) risk remains controversial. Thus, we performed this meta-analysis by searching PubMed, Embase, Web of Science, CBMdisc and CNKI databases until January 30, 2012. In addition, hand searching of the references of identified articles was performed. A total of 10 case-control studies including 11,681 subjects were selected to evaluate the possible association. Our results showed evidence for significant association between the IL-6 gene −572 C/G polymorphism and T2DM risk (for G allele vs. C allele: odds ratio [OR] = 1.29, 95% confidence interval [CI] = 1.09-1.52, P = 0.002, P = 0.008 after Bonferroni testing; for G/G vs. C/C: OR = 1.89, 95% CI = 1.51-2.37, P < 0.00001, P < 0.00004 after Bonferroni testing; for GG vs. G/C + C/C: OR = 1.75, 95% CI = 1.20-2.56, P = 0.004, P = 0.016 after Bonferroni testing; for G/G + G/C vs. C/C: OR = 1.32, 95% CI = 1.11-1.57, P = 0.001, P = 0.004 after Bonferroni testing). In addition, similar results were obtained in the subgroup analysis based on ethnicity. In summary, the present meta-analysis suggests a significant association between the IL-6 gene −572 G allele and increased risk of T2DM.

Susceptibility of NPPA and IL6 with Type 2 Diabetes and Hypertension in Punjab, Pakistan

“…In line to our study, Yin et al (2013) evidently found the significant association between the risk of disease and rs1800796 [OR = 1.29 (1.09-1.52), p = 0.002] in the Chinese population. It is suggested that -572 G allele increased the risk of T2D in the corresponding population (Yin et al, 2013).…”

“…A Natriuretic Peptide Precursor A gene (NPPA; chromosome location 1p36.21) containing rs5064 was reported to be associated with hypertension, which is involved in the predisposition of diabetes. The Interleukin-6 (IL6; chromosome location 7p21) gene was reported to be involved in insulin resistance and increased the risk of T2D development (Conen et al, 2007;Meiner et al, 2008;Yin et al, 2013).…”

Interleukin-6 and interleukin-17 gene polymorphism association with celiac disease in children

“…Fernandes et al (10) reported that patients with the IL-6 (-572G/C) G allele had higher IL-6 levels than patients with the CC and CG genotypes, and the G allele was identified as a risk factor for the development of osteoarthritis. The relationship of this polymorphism with Type 2 diabetes was examined in a metaanalysis of 10 studies, which concluded that subjects with the GG genotype were at greater risk of developing the disease (27). In the present study, which examined the relationship of the IL-6 (-572G/C) polymorphism with CD, the GG genotype was determined to be a risk factor for disease development.…”

Association of TGFB1 29C/T and IL6 -572G/C polymorphisms with developmental hip dysplasia: a case–control study in adults with severe osteoarthritis

“…The tested transversion -572G→C has been associated with higher circulating IL-6 levels [19]. This SNP has also been extensively evaluated in disease-association studies, and the most consistent seems to be the association with development of type 2 diabetes mellitus [20]. Overexpression of human IL6 cDNA in MUP/hIL-6 transgenic mice resulted in retarded growth (not related to malnutrition), reduced expression and circulating levels of IGF-1 (important in development of skeletal elements) and reduced expression of the growth hormone receptor [8].…”