Association between the insulin-like growth factor 1 gene rs2195239 and rs2162679 polymorphisms and cancer risk: a meta-analysis

Abstract

BackgroundMany epidemiological studies have suggested that insulin-like growth factor1 (IGF1) gene single-nucleotide polymorphisms (SNPs) may be associated with cancer risk. Among several commonly studied polymorphisms in IGF1 gene, rs2195239 and rs2162679 attracted many attentions. So we perform a meta-analysis to determine potential associations between IGF1 rs2195239 and rs2162679 polymorphisms and cancer risk.MethodsWe retrieved relevant articles from the PubMed, Embase, and Web of Science databases up to April 30, 2018. Ultimately, thirteen studies were included in the present meta-analysis, which involved 12,515 cases and 19,651 controls. The odd ratios (ORs) and their 95% confidence intervals (CIs) were pooled to estimate the strength of the associations.Resultsrs2195239 reduces the overall cancer risk in homozygote model, as well as reducing cancer risk in Asian populations in allele, homozygote, and recessive models. No significant relationship was found between rs2195239 and breast or pancreatic cancer risk. rs2162679 reduces the overall cancer risk in allele, homozygote, dominant, and recessive models, as well as reducing cancer risk in Asian populations in allele, homozygote, and recessive models.ConclusionsIGF1 rs2195239 and rs2162679 were associated with overall cancer risk based on present studies.Electronic supplementary materialThe online version of this article (10.1186/s12881-019-0749-3) contains supplementary material, which is available to authorized users.

Association of IGF1 single-nucleotide polymorphisms with myopia in Chinese children

“…This may explain why IGF-1 resulted in extreme increases in axial length in chicks but has only been related to mild to moderate myopia in humans. Interestingly, rs2162679 of IGF1 had been reported to be associated with several kinds of cancer, in which the allele G could also decrease the risk of cancer onset (Xu et al, 2019). It reminded us that IGF-1 might play similar roles in myopia and cancer.…”

The G allele of the IGF1 rs2162679 SNP is a potential protective factor for any myopia: Updated systematic review and meta-analysis

“…SNP rs2162679 of IGF1 has been reported to be associated with several kinds of cancer [ 40 – 42 ], which reminds us that IGF1 SNPs might play similar role in the onset or progesssion of myopia and cancer. In this study, our meta-analysis shows there is association between IGF1 rs2162679 and any myopia in codominant model (GA vs. AA) and dominant model (GG+GA vs. AA).…”

Procollagen type III amino‐terminal propeptide and insulin‐like growth factor I as biomarkers of growth hormone administration

“…However, mutations in the exons of the IGF1 gene have been related to several SNPs that have been associated with disease states including diabetes 31,32 and cancer. [32][33][34][35][36] The expressed IGF-I protein is comprised of four domains; that is, B (49-77), the amino-terminal domain; C (78-89), A (90-110) and D (111-118), the carboxyl-terminal domain. The domains play different roles in the binding affinity of IGF-I to receptors and binding proteins.…”

“…The amino acid sequence of expressed IGF‐I is identical for all of these isoforms, as the sequence variation occurs in the extension peptide regions of the signalling (isoform 3) and propeptides (isoforms 2–4). However, mutations in the exons of the IGF1 gene have been related to several SNPs that have been associated with disease states including diabetes 31,32 and cancer 32–36 …”