Association between the IL17RA rs4819554 polymorphism and reduced renal filtration rate in the Spanish RENASTUR cohort

Role of IL-17 Variants in Preeclampsia in Chinese Han Women

“…Located on chromosome 22q11.1, IL-17RA is the largest member by far and can combine with many cytokines including IL-17A and IL-17F, and then induce the expression of other inflammatory factors [ 11 ]. The single nucleotide polymorphisms (SNPs) IL-17A rs2275913 (-197G/A) and IL-17RA rs4819554 (-809A/G) are located in promoter region [ 12 , 13 ] and IL-17F rs763780 (7488T/C) is within exon 3, all three SNPs can influence the expression of IL-17 and IL-17R . Liu XK and his colleagues [ 12 ] identified that the region between -232 and -159 of IL-17A has an inducible promoter activity.…”

“…Kawaguchi [ 14 ] et al have shown that the IL-17F rs763780 can cause a His-to-Arg substitution at amino acid 161 (H161R), thus influence the risk of asthma and is a natural IL-17F antagonist in the known polymorphisms of IL-17 . In addition, the rs2275913, rs763780 and rs4819554 are all tag SNPs and most frequently studied among the enormous genes of IL-17A, IL-17F and IL-17RA, and previous studies indicated that these three SNPs are associated with diseases such as recurrent pregnancy loss (RPL), rheumatoid arthritis (RA), inflammatory bowel disease, and kidney disorders [ 13 , 15 – 17 ]. The present study therefore investigated the association between SNPs rs2275913, rs763780, and rs4819554 and susceptibility to PE in Chinese Han women.…”

Interleukin 17 Receptor a Haplotype Analysis in Chronic Spontaneous Urticaria

“…In contrast, this promoter variant did not show a signi cant association with alopecia areata risk in a Korean population [21]. Nevertheless, the rs4819554*A allele was more frequent in patients with papillary thyroid cancer than in control patients [22] and was associated with an increased risk of developing end-stage renal disease (23) . At the rs4819554 site in the IL17RA gene, the genomic sequence with G allele displayed an SP1 transcription factor consensus sequence; however, this consensus sequence was absent in the sequence with A variant [22].…”

“…Another main nding in our results, patients carrying rs4819554*AA genotype was associated with more prolonged disease duration, concomitant angioedema, and positive ASST status, advanced stage in treatment, and worst quality of life score in CSU. Similarly, the homozygosity of AA was associated with more deterioration of renal function [23] and higher primary graft dysfunction [24]. The A allele of IL17RA gene also showed a signi cant difference between the early onset AA and late-onset AA in a Korean population [21].…”

“…After analyzing several SNPs in coding and regulatory regions in two Spanish cohorts with ankylosing spondylitis (AS), results indicated the genetic role of our promoter variant in the development of severe forms of AS [14]. Interestingly, rs4819554* A allele was linked to an increased expression of the IL-17RA protein and higher levels of Th17 cell subsets [23], which might explain the increased severity of immune-related diseases.…”