Association between the GRM7 rs3792452 polymorphism and attention deficit hyperacitiveity disorder in a Korean sample

Abstract

BackgroundThe purpose of this study was to investigate the association between the ionotropic and glutamate receptors, N-methyl D-asparate 2A (GRIN2A) and 2B (GRIN2B), and the metabotropic glutamate receptor mGluR7 (GRM7) gene polymorphisms and attention-deficit hyperactivity disorder (ADHD) in Korean population.MethodsWe conducted a case–control analysis of 202 ADHD subjects and 159 controls, performed a transmission disequilibrium test (TDT) on 149 trios, and compared scores from the continuous performance test (CPT), the Children’s Depression Inventory (CDI), and the State-Trait Anxiety Inventory for Children (STAIC) according to the genotype of the glutamate receptor genes.ResultsThere were no significant differences in the genotype or allele frequencies of the GRIN2A rs8049651, GRIN2B rs2284411, or GRM7 rs37952452 polymorphisms between the ADHD and control groups. For 148 ADHD trios, the TDT analysis also showed no preferential transmission of the GRIN2A rs8049651 or GRIN2B rs2284411 polymorphisms. However, the TDT analysis of the GRM7 rs3792452 polymorphism showed biased transmission of the G allele (χ2 = 4.67, p = 0.031). In the ADHD probands, the subjects with GG genotype in the GRM7 rs37952452 polymorphism had higher mean T-scores for omission errors on the CPT than did those with the GA or AA genotype (t = 3.38, p = 0.001). In addition, the ADHD subjects who were homozygous for the G allele in the GRM7 rs37952452 polymorphism had higher STAIC-T (t = 5.52, p < 0.001) and STAIC-S (t = 2.74, p = 0.007) scores than did those with the GA or AA genotype.ConclusionsThese results provide preliminary evidence of an association between the GRM7 rs37952452 polymorphism and selective attention deficit and anxiety found within the Korean ADHD population.

Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures

“…In previous studies, GRM7 (mGluR7) has been shown to be associated with neurological disorders such as schizophrenia, hearing impairment and ADHD [48][49][50] . Although ELFN1 has not been reported as a major genetic factor for any neuropsychiatric disorder, we expect that further genetic investigation will demonstrate its involvement in neurodevelopmental disorders other than epilepsy and ADHD, given the shared genetic architecture among mental disorders that has been revealed in recent studies 51,52 .…”

A functional variant in SLC1A3 influences ADHD risk by disrupting a hsa‐miR‐3171 binding site: A two‐stage association study

“…GWAS have indicated that glutamatergic neurotransmission system genes were potentially associated with ADHD risk and/or symptoms, including GRIK1 (rs363512), GRIK4 (r s 655824) and GRM5 (rs5016282), and GRID2 (rs6815704) . Besides, GRIN2A , GRIN2B and GRM7 were also implicated in ADHD susceptibility and/or treatment . Magnetic resonance spectroscopy has shown that there was increased glutamatergic tone in the frontal and striatal brain regions of patients with ADHD .…”

“…8 Besides, GRIN2A, GRIN2B and GRM7 were also implicated in ADHD susceptibility and/or treatment. [9][10][11][12][13][14] Magnetic resonance spectroscopy has shown that there was increased glutamatergic tone in the frontal and striatal brain regions of patients with ADHD. [15][16][17] Additionally, glutamate uptake was discovered to be aberrant in the prefrontal cortex (PFC) of the spontaneous hypertensive rat (SHR, ADHD animal model).…”

Test for association of common variants in GRM7 with alcohol consumption

“…Although there has been work examining the effect of human glutamate metabotropic receptor 7 ( GRM7 ) polymorphisms on human substance use disorders, the majority of the work has focused on psychiatric disorders (Saus et al, 2010), including bipolar disorder (Alliey-Rodriguez et al, 2011), schizophrenia (Ganda et al, 2009; Ohtsuki et al, 2008; Shibata et al, 2009), major depressive disorder (Breen et al, 2011; Hamilton, 2011; Muglia et al, 2010; Pergadia et al, 2011; Shyn et al, 2011), panic disorder (Otowa et al, 2009), autism spectrum disorders (Yang & Pan, 2013), and ADHD (Elia et al, 2011; Park et al, 2013). Although not genome-wide significant, studies have found evidence for an association between GRM7 and nicotine dependence and cessation success (Uhl et al, 2010), and alcoholism (Li et al, 2011).…”