Association between the efficacy of fluoxetine treatment in obsessive–compulsive disorder patients and SLC1A1 in a Han Chinese population

Zhang, Kai; Cao, Leiming; Zhu, Wei; Wang, Guoqiang; Wang, Qingzhong; Hu, Hao; Zhao, Min

doi:10.1016/j.psychres.2015.06.039

Cited by 7 publications

(9 citation statements)

References 6 publications

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“…The Chinese version of the Y-BOCS is a repeatable and sensitive computerized cognitive test with good validity and reliability. The assessment using the Y-BOCS was performed as reported previously 25. A positive response to treatment was defined as a 25% decrease in the Y-BOCS total score.…”

Section: Methodsmentioning

confidence: 99%

<p>Impact of serotonin transporter gene on rTMS augmentation of SSRIs for obsessive compulsive disorder</p>

Zhang¹,

Fan²,

Yuan³

et al. 2019

NDT

Self Cite

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Objective Repetitive transcranial magnetic stimulation (rTMS) is beneficial for treatment-resistant patients with obsessive-compulsive disorder (OCD). The serotonin transporter gene ( SLC6A4 ) may be associated with OCD. We aimed to determine whether SLC6A4 impacts the beneficial effects of rTMS in patients with OCD treated with selective serotonin reuptake inhibitors (SSRIs). Methods Fifty-seven untreated patients with OCD were randomly assigned to receive active or sham rTMS in a 4-week double-blind study. The participants received 1-Hz rTMS over the supplementary motor area once per day, for 5 days a week, for 4 weeks. One of the widely employed SSRIs was utilized at the initiation of active or sham rTMS. Yale–Brown obsessive–compulsive scale (Y-BOCS) scores were used for assessing the symptoms. The most-researched polymorphism of SLC6A4 , 5-HTTLPR (L/S), was also examined. Results Y-BOCS scores in the active group at the completion of the treatment were significantly lower than those in the sham group. Interestingly, the improvement in Y-BOCS scores in patients with the LL genotype treated with active rTMS was significantly ( p <0.05) greater than in those treated with sham rTMS. Conversely, rTMS did not produce significant improvements in S allele carriers. Conclusions The findings of this study suggest that rTMS can augment the beneficial effects of SSRIs in OCD patients with the LL genotype of 5-HTTLPR. Therefore, the presence of 5-HTTLPR (L/S) in SLC6A4 may be a predictable biomarker for the beneficial effects of rTMS, although more studies using larger sample sizes are warranted for confirming the results.

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Section: Methodsmentioning

confidence: 99%

<p>Impact of serotonin transporter gene on rTMS augmentation of SSRIs for obsessive compulsive disorder</p>

Zhang¹,

Fan²,

Yuan³

et al. 2019

NDT

Self Cite

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“…A recent meta-analysis with 815 trios, 306 patients with OCD, and 634 controls also reported no significant association between SLC1A1 (nine SNPs) and OCD [ 18 ]. Furthermore, Zhang et al [ 17 ] found no association between SLC1A1 (rs3780412, rs301430) and OCD (OCD, n = 340 and control, n = 350). A case-control study involving patients of the Han Chinese population also reported no association between rs301430 or rs3780412 of SLC1A1 and OCD [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, Zhang et al [ 17 ] found no association between SLC1A1 (rs3780412, rs301430) and OCD (OCD, n = 340 and control, n = 350). A case-control study involving patients of the Han Chinese population also reported no association between rs301430 or rs3780412 of SLC1A1 and OCD [ 17 ]. Our findings are in accordance with these studies, suggesting a lack of association between SLC1A1 SNPs and OCD.…”

Section: Discussionmentioning

confidence: 99%

“…Among all variants of SLC1A1 , we selected six SNPs (rs2228622, rs3780412, rs301430, rs301434, rs3087879, rs301443) that have been most frequently examined in previous studies and often associated with OCD and/or obsessive-compulsive symptoms in single-marker or haplotype analyses [ 10 – 17 , 19 , 20 , 37 – 40 ]. Genomic DNA was extracted from blood or saliva.…”

Section: Methodsmentioning

confidence: 99%

“…Four studies reported a positive association between SLC1A1 and OCD in single SNP analyses [ 10 – 13 ], while three additional studies reported a significant association between SLC1A1 and OCD in haplotype analyses, but not in single SNP analyses [ 14 – 16 ]. However, one study found no significant association between two SNPs of SLC1A1 and OCD, although a significant influence of SNPs on fluoxetine response was observed [ 17 ]. A meta-analysis comprising 815 trios, 306 patients with OCD, and 634 controls found no significant influences of SLC1A1 (nine SNPs) on OCD [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Association between glutamate transporter gene polymorphisms and obsessive-compulsive disorder/trait empathy in a Korean population

et al. 2018

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Accumulating evidence suggests that the glutamatergic system plays a major role in the pathophysiology of obsessive compulsive disorder (OCD) and empathic processing. Particularly, genetic influence of glutamate transporter gene (SLC1A1) on OCD has been frequently replicated in previous studies, but several studies did not replicate the result. Therefore, we aimed to replicate the associations between the SLC1A1 and OCD in a Korean population. In addition, we investigated the influence of SLC1A1 on trait empathy, impairments in which are characteristic of OCD. Six single-nucleotide polymorphisms (SNP) of SLC1A1 were genotyped in 615 patients with OCD and 508 healthy controls. The interpersonal reactivity index (IRI)—which consists of four subscales (perspective taking, PT; fantasy seeking, FS; empathic concern, EC; personal distress, PD)—was assessed from 277 patients with OCD and 395 controls. There were no significant associations between OCD and SNPs or haplotypes of SLC1A1. Patients with OCD exhibited significantly lower PT and higher PD scores than controls. The C-T-G haplotype at rs301430-rs301434-rs3087879 of SLC1A1 was significantly associated with higher PD scores after adjusted for age, sex, and OCD status. Our results suggest that six common SNPs of SLC1A1 may not contribute to the development of OCD, but may contribute to certain aspect of trait empathy such as personal distress. However, insufficient sample size and limited number of SLC1A1 SNPs may have reduced the likelihood of detecting significant associations. Therefore, further studies with larger sample size and more tag SNPs of the SLC1A1 gene were warranted.

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Genetics of Childhood and Adolescent Anxiety and Obsessive-Compulsive Disorders

Arnold

Antonyan

Routledge

et al. 2022

Handbook of Child and Adolescent Anxiety Disorders

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Association between the efficacy of fluoxetine treatment in obsessive–compulsive disorder patients and SLC1A1 in a Han Chinese population

Cited by 7 publications

References 6 publications

<p>Impact of serotonin transporter gene on rTMS augmentation of SSRIs for obsessive compulsive disorder</p>

<p>Impact of serotonin transporter gene on rTMS augmentation of SSRIs for obsessive compulsive disorder</p>

Association between glutamate transporter gene polymorphisms and obsessive-compulsive disorder/trait empathy in a Korean population

Genetics of Childhood and Adolescent Anxiety and Obsessive-Compulsive Disorders

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