Association between the Dietary Inflammatory Index and Gastric Disease Risk: Findings from a Korean Population-Based Cohort Study

Sreeja, Sundara Raj; Le, Trong-Dat; Eom, Bang Wool; Oh, Seung Hyun; Shivappa, Nitin; Hébert, James R.; Kim, Mi Kyung

doi:10.3390/nu14132662

Cited by 11 publications

(8 citation statements)

References 77 publications

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“…The total score of the DII was −8.20 to +6.36 in Korean population cohorts. 30 Median (Standard Deviation, SD) and range of the Energy Adjusted DII (E-DII) in the Mitchelstown cohort were −1.40±0.1 and −5.10 to +3.68. 34 A study from Xiangya Hospital [Xiangya, Hunan Province] calculated that the average E-DII was +0.68± 0.08, and the score ranged from –5.32 to +4.26, but the study population was Americans.…”

Section: Discussionmentioning

confidence: 99%

Pro-Inflammatory Diet as a Risk Factor for Stomach Cancer: Findings from a Multicenter Study in Central and Western China

Li,

Zhang,

Wang

et al. 2024

JMDH

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Purpose We conducted a multicenter cross-sectional study in central and western China to explore the association between inflammatory diet and stomach cancer odds. Patients and Methods Participants from five hospitals in the central and western regions were collected. All participants completed the questionnaire we provided before the gastroscopy examination, which includes inquiries about risk factors for stomach cancer and food frequency. All participants underwent gastroscopy, and a mucosal biopsy was confirmed pathologically. Pathological findings were classified as chronic gastritis group, precancerous lesions group and stomach cancer group. Dietary Inflammatory Index (DII) scores were calculated based on the frequency of food occurrences in the questionnaire, and finally SPSS was used to calculate the correlation between variables. Results A total of 1162 patients were included in this study, including 668 cases of chronic gastritis, 411 cases of precancerous lesions, and 83 cases of cancer. A single factor analysis was conducted to examine the risk factors of stomach cancer, revealing a significant association between a pro-inflammatory diet and the stomach cancer odds (p value < 0.05). The results of binary classification analysis further confirmed that a pro-inflammatory diet is a risk factor for stomach cancer 【odds ratio (OR) =7.400)】. Moreover, correlation analysis demonstrated a positive correlation between the severity of gastric mucosal diseases and an inflammatory diet (including anti-inflammatory and pro-inflammatory diets) (r s =0.274, p-value < 0.001). Conclusion Pro-Inflammatory diet is a risk factor for stomach cancer, and may accelerate the progression of stomach mucosal disease.

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Section: Discussionmentioning

confidence: 99%

Pro-Inflammatory Diet as a Risk Factor for Stomach Cancer: Findings from a Multicenter Study in Central and Western China

Li,

Zhang,

Wang

et al. 2024

JMDH

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“…(36) Estrogen hormones regulate mucosal secretion, protect the mucosa from acid-induced damage, and regulate the growth and expression of gastric cells, thereby reducing the risk of gastric inflammation Estrogen regulates human duodenal bicarbonate secretion and reduces the risk of ulcers and gastric disease in females, and a decrease in the level of estrogen induces a depletion in the mucosal defense function. (37) Previous research indicated that females experience lower oxidative stress than males. (38) according to C. Kerksick et al Animal experiments had shown that female sex hormones have a strong anti-ulcer effect and to promote ulcer healing associated with medications (indomethacin, aspirin) that may protect female sex hormones from mucosal damage as an estrogen has been shown to reduce its occurrence.…”

Section: Discussionmentioning

confidence: 99%

Study the effect of Sex hormones in patients with stomach ulcers in Anbar Governorate

2022

pnr

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Background: Stomach ulcer disease (SUD) is common in most parts of the world, where ulcers are caused by inflammation of the stomach lining. SUD affects more than 10% of the world's population. It is one of the most common digestive problems. SUD may occur as a result of endothelial damage when there is an imbalance between defensive factors (gastric mucosal barrier, bicarbonate secretion, and elevated blood flow). Aggressive infectious agents (acid, pepsin, H. pylori, and refluxing bile salts).Testosterone neutralizes stomach acidity, and testosterone has been shown to have a role in protecting stomach ulcers, as testosterone stimulates gastric PGs that suppress stomach acidity. Progesterone thickens gastric mucus and prevents mucosal ulceration. Progesterone also acts as an antioxidant to remove free radicals, by promoting gastric mucosal formation, reducing acidic mucosal secretion, inhibiting pepsinogen production, and reducing lesions. SUD are relatively rare during pregnancy, and estrogen exhibits a protective effect against the incidence and severity of SUD, and the risk of ulcers is lower in women compared with men.Methods: We enrolled 60 patients divided into thirty males and thirty females with SUD and 60 healthy controls divided into thirty males and thirty females individuals who did not have the disease and had no history of smoking or drinking alcohol. We measure serum (Testosterone, Progesterone, and Estrogen).Results: Serum (Testosterone, Progesterone, and Estrogen) levels were significantly decreased in SUD patients compared to controls.

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“…Never-smokers included individuals who had either never smoked or had smoked fewer than 100 cigarettes in their lifetime. Now-smokers were participants who had smoked at least 100 cigarettes in their lifetime and reported consuming a non-zero number of cigarettes per day within the past 30 days 8 . Alcohol drinking status was classified into four distinct categories, reflecting their alcohol consumption patterns: Never drinkers (lifetime abstainers), former drinkers (abstinent within the past year), moderate drinkers (1 or 2 drinks per day for females/males, respectively), and heavy drinkers (>1 or >2 drinks per day for females/males, respectively, and/or frequent binge drinking) 11 , 19 .…”

Section: Methodsmentioning

confidence: 99%

“…Lifestyle choices such as smoking and excessive alcohol consumption contribute to heightened oxidative stress in individuals infected with H. pylori 7 . Furthermore, existing evidence suggests that specific dietary behaviors, characterized by the consumption of nutritionally suboptimal foods, are correlated with an increased risk of contracting H. pylori 8 . Furthermore, numerous studies have explored the correlation between oxidative stress and mortality.…”

Section: Introductionmentioning

confidence: 99%

Association of oxidative balance score with helicobacter pylori infection and mortality in the US population

Xiong,

Xu,

Zhu

et al. 2024

Int. J. Med. Sci.

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Background: Limited research has examined the association between Oxidative Balance Score (OBS) and mortality, particularly in individuals with Helicobacter pylori (H. pylori) infection. This study investigates the correlation between OBS and H. pylori infection and their impacts on all-cause mortality within a cohort of individuals, considering both infected and uninfected individuals. Methods: Data from the National Health and Nutrition Examination Survey (NHANES) 1999-2018, comprising 4,532 participants, were analyzed. Logistic regression analyses assessed the relationship between H. pylori infection and relevant covariates. Cox regression and restricted cubic spline analysis evaluated the association between total OBS, lifestyle OBS, dietary OBS, and all-cause mortality in H. pylori -positive and -negative individuals. Results: Restricted cubic spline modeling revealed a linear relationship between total OBS and all-cause mortality, particularly in H. pylori -negative patients. Total OBS, dietary OBS, and lifestyle OBS inversely correlated with H. pylori infection, even after adjusting for confounders. Higher dietary OBS was associated with decreased mortality risk exclusively in H. pylori -positive individuals, while lifestyle OBS was associated with mortality only in H. pylori -negative individuals. These findings underscore the complex relationships between OBS, H. pylori infection, and mortality, stressing the importance of infection status in assessing oxidative balance's impact on health. Conclusion: In this sample, higher OBS was associated with lower H. pylori infection risks. Dietary OBS correlated significantly with all-cause mortality in H. pylori -positive individuals, while lifestyle OBS was notably associated with mortality in H. pylori -negative participants. Further research is necessary to elucidate the underlying mechanisms and clinical implications of these findings.

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Association between the Dietary Inflammatory Index and Gastric Disease Risk: Findings from a Korean Population-Based Cohort Study

Cited by 11 publications

References 77 publications

Pro-Inflammatory Diet as a Risk Factor for Stomach Cancer: Findings from a Multicenter Study in Central and Western China

Pro-Inflammatory Diet as a Risk Factor for Stomach Cancer: Findings from a Multicenter Study in Central and Western China

Study the effect of Sex hormones in patients with stomach ulcers in Anbar Governorate

Association of oxidative balance score with helicobacter pylori infection and mortality in the US population

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