Association between the DICER rs1057035 Polymorphism and Cancer Risk: Evidence from a Meta-analysis of 1,2675 Individuals

Yu, Yang; Kuang, Dan; Yin, Xiaoxv

doi:10.7314/apjcp.2015.16.1.119

Cited by 9 publications

(9 citation statements)

References 36 publications

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“…However, conclusions of miRNA biogenesis pathway genes polymorphisms and cancer risk remain inconsistent, which may cause by the heterogeneity of the cancer subtype, sample size and the ethnicity of patients. Yu, Kuang & Yin (2015) conducted a meta-analysis synthesizes sevens studies with multi-type cancer and found the C allele of the DICER rs1057035 polymorphism probably decreases cancer risk (We included more studies in our studies and found the same results in DICER rs1057035). This study based on the association of a single SNP or gene with cancer risk, which may weaken gene’s biological value.…”

Section: Discussionmentioning

confidence: 93%

MicroRNA biogenesis pathway genes polymorphisms and cancer risk: a systematic review and meta-analysis

Zhao

Zhu

et al. 2016

PeerJ

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MicroRNAs (miRNAs) may promote the development and progression of human cancers. Therefore, components of the miRNA biogenesis pathway may play critical roles in human cancer. Single nucleotide polymorphisms (SNPs) or mutations in genes involved in the miRNA biogenesis pathway may alter levels of gene expression, affecting disease susceptibility. Results of previous studies on genetic variants in the miRNA biogenesis pathway and cancer risk were inconsistent. Therefore, a meta-analysis is needed to assess the associations of these genetic variants with human cancer risk. We searched for relevant articles from PubMed, Web of Science, CNKI, and CBM through Jun 21, 2016. In total, 21 case-control articles met all of the inclusion criteria for the study. Significant associations were observed between cancer risk and the DGCR8polymorphism rs417309 G >A (OR 1.22, 95% CI [1.04–1.42]), as well as the DICER1 polymorphism rs1057035 TT (OR 1.13, 95% CI [1.05–1.22]). These SNPs exhibit high potential as novel diagnostic markers. Future studies with larger sample sizes and more refined analyses are needed to shed more light on these findings.

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Section: Discussionmentioning

confidence: 93%

MicroRNA biogenesis pathway genes polymorphisms and cancer risk: a systematic review and meta-analysis

Zhao

Zhu

et al. 2016

PeerJ

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“…For example, some studies found association between Dicer1 rs3742330 and rs1057035 polymorphisms, and various cancer susceptibility and/or survival in cancerous patients with T cell lymphoma and hepatocellular carcinoma. 16,34 In a meta-analysis, Yu et al 35 The effect of Dicer1 rs3742330/Drosha rs10719GG/TC +CC, Dicer1 rs3742330/RAN rs14035 GG/CC, and Dicer1 rs3742330/XPO5 rs11077 GG/AC+CC combinations with the increased risk of idiopathic recurrent pregnancy loss has been shown by Jung et al 22 Moreover, they showed the association between RAN rs14035 CT, Dicer1 rs3742330/ RAN rs14035 AA+AG/CT+TT, Drosha rs10719/RAN rs14035 TC+CC/CT+TT, and RAN rs14035/XPO5 rs11077 CT+TT/AA combinations and the reduced risk of this complication. The relationship between Dicer1 rs3742330 A allele and AA genotype with azoospermia was reported by Fu et al 38 The TT genotype of the Dicer1 rs1057035 polymorphism was associated with the lower risk of Graves' disease development (P = 0.0098).…”

Section: Discussionmentioning

confidence: 99%

Relationships between Dicer 1 polymorphism and expression levels in the etiopathogenesis of preeclampsia

Eskandari

Teimoori

Rezaei

et al. 2018

J of Cellular Biochemistry

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Preeclampsia (PE) is a pregnancy-specific complication which is a major cause of maternal and fetal morbidity and mortality. Recent studies have shown the aberrant expression of microRNAs (miRNAs) in the placenta of patients with PE. Dicer1 is a key enzyme in the generation of small noncoding RNAs including miRNAs. The aim of this study is to investigate the relationship between maternal and placental Dicer1 rs3742330 polymorphism and placental Dicer1 mRNA expression in PE and normotensive pregnant women. The blood and placenta of PE pregnant and normotensive pregnant women were collected after delivery. Dicer1 rs3742330 polymorphism was genotyped using PCR-RFLP method. The mRNA expression levels were measured using quantitative real time PCR. The maternal Dicer1 rs3742330 polymorphism was not associated with PE or PE severity; however, the placental Dicer1 rs3742330 AG genotype was associated with two fold higher risk of PE and three fold higher risk of severe PE (P = 0.018 and P = 0.005, respectively). The relative mRNA expression of Dicer1 gene in the placenta did not differ between the two groups. In addition, the relative mRNA expression of Dicer1 gene was significantly lower in the placenta of women with rs3742330 AG+GG genotypes in the total population (P = 0.028) and PE women (P = 0.004), but not in the control group. In conclusion, there was a relationship between placental but not maternal Dicer1 rs3742330 polymorphism and PE. There was no difference in Dicer1 mRNA expression between the PE and control groups; however, it was significantly lower in the placenta of women with rs3742330 AG+GG genotypes.

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“…Several studies have found the relationship between DICER1 and DROSHA polymorphisms and several diseases, but the published reports on their impacts on RSA are rare …”

Section: Discussionmentioning

confidence: 99%

“…DROSHA and DICER1 genes are located on chromosomes 5 and 14, respectively . There are several single nucleotide polymorphisms (SNPs) in DROSHA and DICER1 genes, and their effects on various diseases have been investigated …”

Section: Introductionmentioning

confidence: 99%

“…17,18 There are several single nucleotide polymorphisms (SNPs) in DROSHA and DICER1 genes, and their effects on various diseases have been investigated. 16,19 Two other studies demonstrated that the combination of DROSHA and DICER1 polymorphisms could increase RSA risk. 20,21 To date, very few studies have been conducted on the effects of DROSHA and DICER1 polymorphisms on RSA.…”

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confidence: 99%

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The effects of DICER1 and DROSHA polymorphisms on susceptibility to recurrent spontaneous abortion

Ghasemi

Rezaei

Yazdi

et al. 2019

Clinical Laboratory Analysis

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Background Recurrent spontaneous abortion (RSA) is a serious problem in pregnancy. The exact etiology of RSA is unknown in more than 50% of all the patients. However, genetic variations are known as susceptibility factors for idiopathic RSA. Considering the role of miRNA biosynthesis machinery in the miRNA production and effect of miRNAs on various diseases, this study aimed to evaluate the effects of DICER1 rs3742330 and DROSHA rs6877842 polymorphisms on RSA risk. Methods In this case‐control study, 150 RSA patients and 195 age‐matched healthy female controls were recruited. Both polymorphisms were genotyped using PCR‐RFLP method. Results The frequency of DICER1 rs3742330AG genotype was higher in the control group (P = .022). There was a statistically significant association between rs3742330 polymorphism and a reduced RSA risk in dominant and allelic models (P = .013 and P = .007, respectively). No statistically significant association was found between DROSHA rs6877842 variant and RSA risk. The combination of AG and GC genotypes and G‐G alleles of DICER1 rs3742330 and DROSHA rs6877842 polymorphisms led to a decreased RSA risk. However, the synergic effect of rs3742330A and rs6877842G alleles (A‐G) and AA‐GG genotypes was associated with an increased RSA risk. Conclusion the DICER1 rs3742330AG genotype and combination of AG and GC genotypes and G‐G alleles of DICER1 rs3742330 and DROSHA rs6877842 polymorphisms were associated with a reduced RSA risk.

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Association between the DICER rs1057035 Polymorphism and Cancer Risk: Evidence from a Meta-analysis of 1,2675 Individuals

Cited by 9 publications

References 36 publications

MicroRNA biogenesis pathway genes polymorphisms and cancer risk: a systematic review and meta-analysis

MicroRNA biogenesis pathway genes polymorphisms and cancer risk: a systematic review and meta-analysis

Relationships between Dicer 1 polymorphism and expression levels in the etiopathogenesis of preeclampsia

The effects of DICER1 and DROSHA polymorphisms on susceptibility to recurrent spontaneous abortion

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