Association between the CYP1A1 polymorphisms and hepatocellular carcinoma: a meta-analysis

Abstract

ABSTRACT. Numerous studies have evaluated the association between CYP1A1 gene polymorphisms and hepatocellular carcinoma (HCC) risk. However, the specific association is still controversial. The aim of our study was to clarify the effects of CYP1A1 gene polymorphisms (3801 T＞C and A2455G) on HCC risk by conducting a meta-analysis. We conducted searches of the literature published in PubMed and EMBASE databases up to April 2014. We estimated the pooled odds ratio with its 95% confidence interval to assess the association using a fixed or random-effects model. Publication bias was investigated by the Begg funnel plot. Meta-analysis was performed using the STATA package version 12.0. Meta-analysis results showed no significant association between the CYP1A1 3801 T＞C polymorphism and HCC risk. In a subgroup analysis by nationality, we found a significant association between 3801 T＞C polymorphism and HCC risk in Asians CYP1A1 polymorphisms and hepatocellular carcinoma (TT vs TC: OR = 0.77, 95%CI = 0.60-0.99). As for A2455G, the metaanalysis indicated no significant association between the CYP1A1 A2455G polymorphism and HCC risk. In conclusion, the 3801 T＞C polymorphism in the CYP1A1 gene may be related to increased risk of HCC in Asians. Conclusive evidence on the effects of the variants in HCC should be addressed in further studies.

Nuclear localization dictates hepatocarcinogenesis suppression by glycine N-methyltransferase

“…1 ). Indeed, different studies have shown the association of Cyp1A1 polymorphisms with the risk of developing breast [43] , liver [44] , and lung [ 45 , 46 ], and Tomcod [47] cancers. Studies in humans suggest that variations in CYP1A1 cDNA influences the genetic susceptibility to neoplasia [48] .…”

“…Therefore, the inhibition of CYP1A1 expression by GNMT may suppress the development of tumors associated with Cyp1A polymorphism. PREX2 is a regulator of the small guanosine triphosphatase Rac, that inhibits PTEN (Phosphatase and tensin homolog) activity, thus upregulating the PI3K/AKT signaling pathway [ 43 , 44 , 49 ]. Different studies decribed the beneficial therapeutic effect of PI3K/AKT inhibitors especially if associated with RAS/MEK/ERK inhibitors [49] .…”

Genetic Polymorphism and Alcohol Metabolism

“…Gene polymorphism in GSTM1, GSTT1, GSTP1, CYP1A1 and CYP2E1 represent risk-modifying factors for ethanol related diseases in Brazilian alcoholics and controls with similar ethnic backgrounds. Also the persons with these genotypes are genetically more prone to the development of alcoholic pancreatitis and alcoholic cirrhosis, respectively [60][61][62][63].…”

Molecular Links between Alcohol and Tobacco Induced DNA Damage, Gene Polymorphisms and Patho-physiological Consequences: A Systematic Review of Hepatic Carcinogenesis

“…To investigate whether GSTM1, GSTT1, GSTP1, CYP1A1 and CYP2E1 gene polymorphisms represent risk-modifying factors for ethanol related diseases, a study was conducted involving Brazilian alcoholics and controls with similar ethnic backgrounds (Burim et al, 2004). Results were indicating that persons with these genotypes are genetically more prone to the development of alcoholic pancreatitis and alcoholic cirrhosis, respectively (Lakkakula et al, 2013;Yu et al, 2015).…”