Association between the circulating superoxide dismutase and obstructive sleep apnea: a meta-analysis

Tian, Zongsheng; Sun, Hongying; Kang, Jian; Mu, Zhuangzhuang; Liang, Jing; Li, Mingxian

doi:10.1007/s00405-021-07064-1

Cited by 3 publications

(4 citation statements)

References 30 publications

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“…A recent meta-analysis of 10 studies reported lower SOD concentrations in OSA when compare with the non OSA-control [ 45 ]. However, differently from this study, we conducted separate analyses according to the different biological matrix investigated, plasma/serum vs. whole blood, and we observed significant differences in SOD between OSA and non-OSA groups in whole blood, but not in serum.…”

Section: Discussionmentioning

confidence: 99%

Circulating Superoxide Dismutase Concentrations in Obstructive Sleep Apnoea (OSA): A Systematic Review and Meta-Analysis

Pau

Mangoni

Zinellu³

et al. 2021

Antioxidants

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Obstructive Sleep Apnoea (OSA) is characterized by a pro-oxidant state that results from the recurrent hypoxia-reoxygenation cycles. Superoxide dismutase (SOD), a key antioxidant enzyme involved in the detoxification of superoxide radicals, could represent a reliable marker to monitor the antioxidant defences in OSA. In order to capture and critically appraise the available evidence, we performed a systematic review and meta-analysis of studies reporting SOD concentrations in OSA patients and non-OSA controls in the electronic databases Pubmed, Web of Science, Scopus and Google Scholar. In total, 13 studies in 847 OSA patients and 438 non-OSA controls were included in the meta-analysis. Blood SOD concentrations were significantly lower in OSA patients (SMD = 0.87, p < 0.001). By contrast, serum/plasma SOD concentrations were not significantly different between the two groups. Although extreme between-study heterogeneity was observed, the SMD was not substantially modified when individual studies were sequentially removed. In conclusion, we observed that whole blood, but not serum/plasma, SOD concentrations were significantly lower in OSA patients compared with controls. Our meta-analysis suggests an impaired antioxidant defence in OSA that is more robustly assessed in the corpuscular biological matrix and provides useful background information for further studies investigating the association between SOD changes and clinical status in OSA.

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Section: Discussionmentioning

confidence: 99%

Circulating Superoxide Dismutase Concentrations in Obstructive Sleep Apnoea (OSA): A Systematic Review and Meta-Analysis

Pau

Mangoni

Zinellu³

et al. 2021

Antioxidants

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“…Superoxide, a vital cellular oxidizing agent, undergoes dismutation catalyzed by the superoxide dismutase (SOD) enzyme family, leading to the dissociation of the superoxide anion into molecular oxygen and hydrogen peroxide in healthy individuals [41][42][43][44][45]. However, OSAS patients have been reported to have lower plasma levels of SOD [30,31]. Catalase (CAT) plays a crucial role in mitigating oxidative stress by facilitating the breakdown of hydrogen peroxide into water and molecular oxygen [39].…”

Section: Antioxidant Defensementioning

confidence: 99%

“…In the context of OSAS, TNF-α concentration is elevated compared to healthy subjects, underscoring its potential contribution to cardiovascular risks in OSAS patients. Remarkably, continuous positive airway pressure (CPAP) treatment demonstrates the capacity to normalize TNF values in OSAS individuals, suggesting a potential avenue for mitigating the inflammatory impact associated with this sleep disorder [29][30][31].…”

Section: Tumor Necrosis Factor-αmentioning

confidence: 99%

Unraveling the Complexities of Oxidative Stress and Inflammation Biomarkers in Obstructive Sleep Apnea Syndrome: A Comprehensive Review

Lavalle,

Masiello,

Iannella

et al. 2024

Life

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Background: Obstructive sleep apnea syndrome (OSAS), affecting approximately 1 billion adults globally, is characterized by recurrent airway obstruction during sleep, leading to oxygen desaturation, elevated carbon dioxide levels, and disrupted sleep architecture. OSAS significantly impacts quality of life and is associated with increased morbidity and mortality, particularly in the cardiovascular and cognitive domains. The cyclic pattern of intermittent hypoxia in OSAS triggers oxidative stress, contributing to cellular damage. This review explores the intricate relationship between OSAS and oxidative stress, shedding light on molecular mechanisms and potential therapeutic interventions. Methods: A comprehensive review spanning from 2000 to 2023 was conducted using the PubMed, Cochrane, and EMBASE databases. Inclusion criteria encompassed English articles focusing on adults or animals and reporting values for oxidative stress and inflammation biomarkers. Results: The review delineates the imbalance between pro-inflammatory and anti-inflammatory factors in OSAS, leading to heightened oxidative stress. Reactive oxygen species biomarkers, nitric oxide, inflammatory cytokines, endothelial dysfunction, and antioxidant defense mechanisms are explored in the context of OSAS. OSAS-related complications include cardiovascular disorders, neurological impairments, metabolic dysfunction, and a potential link to cancer. This review emphasizes the potential of antioxidant therapy as a complementary treatment strategy. Conclusions: Understanding the molecular intricacies of oxidative stress in OSAS is crucial for developing targeted therapeutic interventions. The comprehensive analysis of biomarkers provides insights into the complex interplay between OSAS and systemic complications, offering avenues for future research and therapeutic advancements in this multifaceted sleep disorder.

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“…Smoking [ 14 ], alcohol consumption [ 15 ], obesity [ 16 , 17 ], older age [ 18 ], and male gender [ 19 ] may act as other risk factors for OSAS. Several recent meta-analyses showed the association of genetic [ 20 , 21 ] and inflammation factors [ 22 , 23 , 24 ], hormones [ 25 , 26 ], and enzymes [ 27 , 28 ] with the risk of OSAS.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Plasma/Serum Adiponectin (an Anti-Inflammatory Factor) Levels in Adult Patients with Obstructive Sleep Apnea Syndrome: A Systematic Review and Meta-Analysis

Najafi

Mohammadi

Sadeghi

et al. 2022

Life

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Background and objective: A variety of diseases, including obesity, type ӀӀ diabetes, and cardiovascular diseases are associated with obstructive sleep apnea syndrome (OSAS), and decreased adiponectin levels have been shown to be associated with an increased risk of these diseases. However, the association of blood levels of adiponectin in OSAS patients is a challenging and unknown issue with conflicting results. Therefore, we performed a systematic review and a meta-analysis to evaluate plasma/serum adiponectin levels in adult patients with OSAS. Materials and methods: A comprehensive search in four databases (PubMed/Medline, Web of Science, Scopus, and Cochrane Library) was performed in literature dated older than 12 March 2022, to retrieve the relevant articles. Effect sizes were calculated to show the standardized mean difference (SMD) along with a 95% confidence interval (CI) of plasma/serum of adiponectin between the OSAS patients and controls. The software RevMan 5.3, NCSS 21.0.2, CMA 2.0, trial sequential analysis (TSA) 0.9.5.10 beta, and GetData Graph Digitizer 2.26 were used for data synthesis in the meta-analysis. Results: A total of 28 articles including 36 studies were entered into the meta-analysis. The results showed that pooled SMD was −0.71 (95% CI: −0.92, 0.50; p < 0.00001; I2 = 79%) for plasma/serum levels of adiponectin in OSAS cases compared to the controls. The subgroup analyses showed that the geographical region and the Apnea-Hypopnea-Index (AHI) could be confounding factors in the pooled analysis of plasma/serum adiponectin levels. The sensitivity analysis showed the stability of the results. The radial and L’Abbé plots confirmed evidence of heterogeneity. Trial sequential analysis showed sufficient cases in the meta-analysis. Conclusions: With sufficient cases and stable results, the main finding of the meta-analysis identified significantly reduced plasma/serum levels of adiponectin in OSAS cases compared with the controls. This result suggests a potential role of adiponectin in the pathogenesis of OSAS.

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Association between the circulating superoxide dismutase and obstructive sleep apnea: a meta-analysis

Cited by 3 publications

References 30 publications

Circulating Superoxide Dismutase Concentrations in Obstructive Sleep Apnoea (OSA): A Systematic Review and Meta-Analysis

Circulating Superoxide Dismutase Concentrations in Obstructive Sleep Apnoea (OSA): A Systematic Review and Meta-Analysis

Unraveling the Complexities of Oxidative Stress and Inflammation Biomarkers in Obstructive Sleep Apnea Syndrome: A Comprehensive Review

Evaluation of Plasma/Serum Adiponectin (an Anti-Inflammatory Factor) Levels in Adult Patients with Obstructive Sleep Apnea Syndrome: A Systematic Review and Meta-Analysis

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