Association between the brain-derived neurotrophic factor (BDNF) gene and Schizophrenia in the Chinese population

Chen, Qing-Ying; Chen, Qi; Gao, Feng; Wan, Chunling; Lindpaintner, Klaus; Wang, Lijun; Chen, Zhengxiong; Gao, Zhe; Tang, Jisheng; Li, Xingwang; He, Lin

doi:10.1016/j.neulet.2005.12.033

Cited by 39 publications

(12 citation statements)

References 55 publications

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“…Some of the inconsistencies between reports could be due to the investigation of different populations so far: while studies conducted in Asians have failed to show a BDNF/BP association, most of the association studies carried out in samples of Caucasian origin have reported overrepresentation of the Val allele in affected individuals. Interestingly, a similar trend is seen in association studies of BDNF and schizophrenia [Neves-Pereira et al, 2005;Schumacher et al, 2005;Chen et al, 2006]. Furthermore, it is well established that initial association results are likely to overestimate genetic effects but that true associations could be missed if follow-up was abandoned due to early underpowered negative replication studies [Ioannidis et al, 2001].…”

Section: Discussionmentioning

confidence: 56%

Transmission distortion of BDNF variants to bipolar disorder type I patients from a south american population isolate^,

Kremeyer

Herzberg

García

et al. 2006

American J of Med Genetics Pt B

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Recent reports have implicated polymorphisms in the brain derived neurotrophic factor (BDNF) gene region in the etiology of several psychiatric phenotypes, including bipolar disorder. Significant disease association has been reported for the G allele at SNP rs6265, which encodes for Valine at position 66 of BDNF (Val66Met), an apparently functional variant of this key BDNF. Here we examined a sample of 224 bipolar type I patients and available parents (comprising a total of 212 nuclear families) ascertained in a South American population isolate (Antioquia, Colombia). We tested for transmission distortion to bipolar patients of alleles at the rs6265 polymorphism and at a microsatellite marker 1.3 kb away from this SNP. Significant excess transmission of the rs6265 G allele to cases was observed (chi(2) = 10.77, d.f. = 1, P = 0.001). Two-locus haplotype analysis showed a significant global transmission distortion (chi(2) = 16.059, d.f. = 7, P = 0.025) with an excess transmission of a haplotype comprising the rs6265 G allele and microsatellite allele 227. These results are consistent with previous studies pointing to a role for BDNF in susceptibility to mood disorders.

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Section: Discussionmentioning

confidence: 56%

Transmission distortion of BDNF variants to bipolar disorder type I patients from a south american population isolate^,

Kremeyer

Herzberg

García

et al. 2006

American J of Med Genetics Pt B

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“…In addition, 20–30% of the Met/Met homozygote distribution and nearly 50% of the Met allele frequency exist in the Chinese population [14], [15], which allows analysis of the Met/Met genotype alone to be conducted more readily. To date, data with regards to the relationship between BDNF (rs6265) genotypes and brain structure in the Chinese population is lacking.…”

Section: Introductionmentioning

confidence: 99%

Impact of Brain-Derived Neurotrophic Factor Val66Met Polymorphism on Cortical Thickness and Voxel-Based Morphometry in Healthy Chinese Young Adults

et al. 2012

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BackgroundFollowing voxel-based morphometry (VBM), brain-derived neurotrophic factor (BDNF) Val66Met polymorphism (rs6265) has been shown to affect human brain morphology in Caucasians. However, little is known about the specific role of the Met/Met genotype on brain structure. Moreover, the relationship between BDNF Val66Met polymorphism and Chinese brain morphology has not been studied.Methodology/Principal FindingsThe present study investigated brain structural differences among three genotypes of BDNF (rs6265) for the first time in healthy young Chinese adults via cortical thickness analysis and VBM. Brain differences in Met carriers using another grouping method (combining Val/Met and Met/Met genotypes into a group of Met carriers as in most previous studies) were also investigated using VBM. Dual-approach analysis revealed less gray matter (GM) in the frontal, temporal, cingulate and insular cortices in the Met/Met group compared with the Val/Val group (corrected, P<0.05). Areas with less GM in the Val/Met group were included in the Met/Met group. VBM differences in Met carriers were only found in the middle cingulate cortex.Conclusions/SignificanceThe current results indicated a unique pattern of brain morphologic differences caused by BDNF (rs6265) in young Chinese adults, in which the Met/Met genotype markedly affected the frontal, temporal, cingulate, and insular regions. The grouping method with Met carriers was not suitable to detect the genetic effect of BDNF Val66Met polymorphism on brain morphology, at least in the Chinese population, because it may hide some specific roles of Met/Met and Val/Met genotypes on brain structure.

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“…Many studies have implicated the genes coding for the catechol-O-methyltransferase (COMT ) enzyme, brain-derived neurotrophic factor (BDNF ) and notably neuregulin 1 (NRG1) as candidate genes for schizophrenia (Li et al 1996 ;Egan et al 2001 ;Shifman et al 2002Shifman et al , 2004Glatt et al 2003 ;Handoko et al 2005 ;Lohoff et al 2005 ;Owen et al 2005 ;Chen et al 2006 ;Jonsson et al 2006 ;Ehlis et al 2007 ;Goghari & Sponheim, 2008 ;Okochi et al 2009 ;Zhang et al 2009). There is also a large body of evidence demonstrating the inconsistency of association between polymorphisms in COMT, BDNF and NRG1 genes and psychotic disorders in samples across the globe (Munafo et al 2005 ;Prata et al 2006 ;Kanazawa et al 2007 ;Ikeda et al 2008 ;Sanders et al 2008 ;Jonsson et al 2009 ;Kawashima et al 2009 ;Okochi et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Do COMT, BDNF and NRG1 polymorphisms influence P50 sensory gating in psychosis?

et al. 2010

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Association between the brain-derived neurotrophic factor (BDNF) gene and Schizophrenia in the Chinese population

Cited by 39 publications

References 55 publications

Transmission distortion of BDNF variants to bipolar disorder type I patients from a south american population isolate^,

Transmission distortion of BDNF variants to bipolar disorder type I patients from a south american population isolate^,

Impact of Brain-Derived Neurotrophic Factor Val66Met Polymorphism on Cortical Thickness and Voxel-Based Morphometry in Healthy Chinese Young Adults

Do COMT, BDNF and NRG1 polymorphisms influence P50 sensory gating in psychosis?

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Association between the brain-derived neurotrophic factor (BDNF) gene and Schizophrenia in the Chinese population

Cited by 39 publications

References 55 publications

Transmission distortion of BDNF variants to bipolar disorder type I patients from a south american population isolate,

Transmission distortion of BDNF variants to bipolar disorder type I patients from a south american population isolate,

Impact of Brain-Derived Neurotrophic Factor Val66Met Polymorphism on Cortical Thickness and Voxel-Based Morphometry in Healthy Chinese Young Adults

Do COMT, BDNF and NRG1 polymorphisms influence P50 sensory gating in psychosis?

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Transmission distortion of BDNF variants to bipolar disorder type I patients from a south american population isolate^,

Transmission distortion of BDNF variants to bipolar disorder type I patients from a south american population isolate^,