Association between the APEX1 Asp148Glu polymorphism and prostate cancer, especially among Asians: a new evidence-based analysis

Abstract

BackgroundProstate cancer (Pca) is a serious disease associated with considerable morbidity and mortality. As a causative factor, the Asp148Glu polymorphism has been identified in the apurinic/apyrimidinic endonuclease (APEX1) gene. However, the association among Asians is considered controversial.MethodsEvidence for this association was obtained from the PubMed, Embase, HuGENet and Chinese National Knowledge Infrastructure (CNKI) databases. In the analysis, four models were applied. Associations between the APEX1 polymorphism and the invasiveness of Pca based on the Gleason score, prostate-specific antigen expression and clinical status were also evaluated.ResultsSeven articles were included in the analysis. Positive results were not only discovered in the pooled analysis, but also among patients of mixed descentand Asian descent. However, after considering the Hardy-Weinberg equilibrium (HWE), we observed only a 1.557-fold increase in Pca risk for subjects of Asian descent(GG vs. TT: OR=1.557, 95%CI=1.069-2.268) under the co-dominant model. Additionally, we did not also find any relationship between the APEX1 Asp148Glu polymorphism and invasive Pca risk.ConclusionOn the basis of the function of the APEX1 Asp148Glu polymorphism, recent studies, and our results, we suggest that the APEX1 Asp148Glu polymorphism might be important in stimulating the development of Pca rather than its invasiveness in various populations, especially for Asians.

Comprehensive assessment of the association between estrogen receptor of alpha polymorphisms and the risk of prostate cancer: evidence from a meta-analysis

“…Inclusion criteria: (1) the type of study was case-control; (2) cases were histologically diagnosed with PC patients, the pathological type was adenocarcinoma, control group was unrelated healthy people; (3) the distribution of genotypes was fully justified with Hardy-Weinberg genetic balance law; (4) the literature provided a complete genotype data. Exclusion criteria: (1) there was only case but without control group; (2) study which was repetitive publication; (3) incomplete data [ 13 ].…”

Genetic variants of APEX1 p.Asp148Glu and XRCC1 p.Gln399Arg with the susceptibility of hepatocellular carcinoma

“…34,[42][43][44][45] A recent meta-analysis study revealed a statistically significant of the APEX1 (rs1130409*p.Asp148Glu) variant with the progression of prostate cancer under dominant (OR = 1.159, 95% CI = 1.000-1.159) model. 43 Another meta-analysis report indicated that the APEX1 (rs1130409*p.Asp148Glu) variant could represent an independent risk factor with different types of cancers under dominant (OR = 1.09, p = 0.028) model. Moreover, upon subgroup stratification, the authors reported a significant association with this missense variant among Caucasian subjects under the dominant (OR = 1.11, p = 0.049) model.…”

“…Also, it has a crucial role in the incision mechanism of the AP sites and the regulation of multiple epigenetic processes such as DNA methylation 7,23 . Numerous meta‐analysis studies explored the association of the APEX1 (rs1130409*p.Asp148Glu) variant with the susceptibility of different cancerous diseases but with problematic conclusions 34,42–45 . A recent meta‐analysis study revealed a statistically significant of the APEX1 (rs1130409*p.Asp148Glu) variant with the progression of prostate cancer under dominant (OR = 1.159, 95% CI = 1.000–1.159) model 43 .…”

“…Numerous meta‐analysis studies explored the association of the APEX1 (rs1130409*p.Asp148Glu) variant with the susceptibility of different cancerous diseases but with problematic conclusions 34,42–45 . A recent meta‐analysis study revealed a statistically significant of the APEX1 (rs1130409*p.Asp148Glu) variant with the progression of prostate cancer under dominant (OR = 1.159, 95% CI = 1.000–1.159) model 43 . Another meta‐analysis report indicated that the APEX1 (rs1130409*p.Asp148Glu) variant could represent an independent risk factor with different types of cancers under dominant (OR = 1.09, p = 0.028) model.…”

Relationship between XPD, RAD51, and APEX1 DNA repair genotypes and prostate cancer risk in the male population of Rio de Janeiro, Brazil

“…A missense G → T substitution SNP in the APEX1 gene in exon 5 (rs1130409) changes a critical Asp → Glu residue at codon 148. An up to date report connects this SNP to the development of PCa in Asian descendents ( Chen et al. , 2016 ).…”