Association between the ABO blood group and the human intestinal microbiota composition

Mäkivuokko, Harri; Lahtinen, Sampo J.; Wacklin, Pirjo; Tuovinen, Elina; Tenkanen, H; Nikkilä, Janne; Björklund, Marika; Aranko, Kari; Ouwehand, Arthur C.; Mättö, Jaana

doi:10.1186/1471-2180-12-94

Cited by 97 publications

(80 citation statements)

References 32 publications

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“…A new area of investigation, as highlighted in this review, is the effect of BSH activity on the size and composition of the bile acid pool and indeed how this affects the structure of the microbiome [19,20,25]. While the composition of the microbiome in adult humans is surely a product of nature [31], it is obvious that nurture, particular diet [26] and disease states [6-8] sculpts the composition of the microbiome. On the one hand, high fat diets increase the levels of bile acids in the gut.…”

Section: Discussionmentioning

confidence: 99%

Bile acids and the gut microbiome

Ridlon

Kang

Hylemon

et al. 2014

Current Opinion in Gastroenterology

1,064

909

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Purpose of the review We examine the latest research on the emerging bile acid-gut microbiome axis and its role in health and disease. Our focus revolves around two key microbial pathways for degrading bile salts, and the impact of bile acid composition in the gut on the gut microbiome and host physiology. Recent findings Bile acid pool size has recently been shown to be a function of microbial metabolism of bile acids in the intestines. Recent studies have shown potential mechanisms explaining how perturbations in the microbiome affect bile acid pool size and composition. Bile acids are emerging as regulators of the gut microbiome at the highest taxomic levels. The role of bile acids as hormones and potentiators of liver cancer are also emerging. Summary The host and microbiome appear to regulate bile acid pool size. The host produces a large, conjugated hydrophilic bile acid pool, maintained through positive-feedback antagonism of FXR in intestine and liver. Members of the microbiome utilize bile acids and their conjugates resulting in agonism of FXR in intestine and liver resulting in a smaller, unconjugated hydrophobic bile acid pool. Hydrophilicity of the bile acid pool is associated with disease states. Reduced bile acid levels in the gut are associated with bacterial overgrowth and inflammation. Diet, antibiotic therapy, and disease states affect the balance of the microbiome-bile acid pool.

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Section: Discussionmentioning

confidence: 99%

Bile acids and the gut microbiome

Ridlon

Kang

Hylemon

et al. 2014

Current Opinion in Gastroenterology

1,064

909

View full text Add to dashboard Cite

show abstract

“…These markers have both been associated with an increased type 2 diabetes risk, thus providing a potential explanation for the observed relationships [7,8]. Finally, a recent paper suggested that the ABO blood group is one of the genetically determined host factors that modulate the composition of the intestinal microbiota [9], which participates in metabolism by affecting the energy balance, glucose metabolism and low-grade inflammation [10].…”

Section: Nf L U En C E Of Fa S T I N G Pl a S M A G L U C Os E An Dmentioning

confidence: 97%

ABO and Rhesus blood groups and risk of type 2 diabetes: evidence from the large E3N cohort study

et al. 2014

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“…The microbiomes of non-secretors were more diverse overall; however, non-secretors contained significantly more species of bifidobacteria than secretors. In a follow up study examining ABO status only in secretors, B and AB individuals clustered separately from A and O individuals in ordination analysis of total microbiome composition [28]. While these studies provide proof of principle that genetic variation in ABO and FUT2 can be associated with microbiome composition, the methods employed in these studies have limited resolution.…”

Section: Introductionmentioning

confidence: 99%

ABO antigen and secretor statuses are not associated with gut microbiota composition in 1,500 twins

et al. 2016

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BackgroundHost genetics is one of several factors known to shape human gut microbiome composition, however, the physiological processes underlying the heritability are largely unknown. Inter-individual differences in host factors secreted into the gut lumen may lead to variation in microbiome composition. One such factor is the ABO antigen. This molecule is not only expressed on the surface of red blood cells, but is also secreted from mucosal surfaces in individuals containing an intact FUT2 gene (secretors). Previous studies report differences in microbiome composition across ABO and secretor genotypes. However, due to methodological limitations, the specific bacterial taxa involved remain unknown.ResultsHere, we sought to determine the relationship of the microbiota to ABO blood group and secretor status in a large panel of 1503 individuals from a cohort of twins from the United Kingdom. Contrary to previous reports, robust associations between either ABO or secretor phenotypes and gut microbiome composition were not detected. Overall community structure, diversity, and the relative abundances of individual taxa were not significantly associated with ABO or secretor status. Additionally, joint-modeling approaches were unsuccessful in identifying combinations of taxa that were predictive of ABO or secretor status.ConclusionsDespite previous reports, the taxonomic composition of the microbiota does not appear to be strongly associated with ABO or secretor status in 1503 individuals from the United Kingdom. These results highlight the importance of replicating microbiome-associated traits in large, well-powered cohorts to ensure results are robust.Electronic supplementary materialThe online version of this article (doi:10.1186/s12864-016-3290-1) contains supplementary material, which is available to authorized users.

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Association between the ABO blood group and the human intestinal microbiota composition

Cited by 97 publications

References 32 publications

Bile acids and the gut microbiome

Bile acids and the gut microbiome

ABO and Rhesus blood groups and risk of type 2 diabetes: evidence from the large E3N cohort study

ABO antigen and secretor statuses are not associated with gut microbiota composition in 1,500 twins

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