Association between the 2756A&gt; G variant in the gene encoding methionine synthase and myocardial infarction in Tunisian patients

Jemaa, Riadh; Achouri, Afef; Kallel, Amani; Ali, Samir Ben; Mourali, Sami; Feki, Moncef; Elasmi, Monia; Taieb, Samah Haj; Sanhaji, Haïfa; Omar, Souheil; Mechmèche, Rachid; Kaabachi, Naziha

doi:10.1515/cclm.2008.306

Cited by 10 publications

(4 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The haplotype T-G is observed to confer 4.7-fold risk towards CAD whereas haplotype C-G provides nearly 1.7 fold protection towards development of CAD in studied population of Jammu region. The present study affirms that G-allele and GG- genotype of MS gene polymorphism (rs185087) is add significantly to the risk towards susceptibility of CAD as has been documented earlier [ 9 , 53 , 54 ].…”

Section: Discussionsupporting

confidence: 91%

Association of ESR1 (rs2234693 and rs9340799), CETP (rs708272), MTHFR (rs1801133 and rs2274976) and MS (rs185087) polymorphisms with Coronary Artery Disease (CAD)

Raina

Sharma

Panjaliya

et al. 2020

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Background: Coronary artery disease (CAD) is a complex disease resulting from the cumulative and interactive effects of large number of genes along with environmental exposure. Therefore, the present study was envisaged as an effort to study the association of candidate genes ESR1 (rs2234693 and rs9340799), CETP (rs708272), MTHFR (rs1801133 and rs2274976) and MS (rs185087) polymorphisms with the risk of CAD, targeting the populations of Jammu (JandK). Method: A total of 400 confirmed CAD patients and 400 healthy controls were enrolled for the present study. Genotyping was done by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: ESR1 gene (rs9340799) polymorphism was found to be associated with CAD in all the genetic models. The haplotype analysis of ESR1 (rs2234693 and rs9340799) gene revealed that C-G haplotype was conferring approximately 5-fold risk and T-A haplotype was adding 1.4-fold risk towards the disease. 'T' allele of MTHFR rs1801133 SNP was observed to be responsible for development of CAD in our study population (p < 0.0001). In case of MTHFR (rs1801133 and rs2274976) gene, the haplotype T-G was observed to confer 4.7-fold risk towards CAD whereas haplotype C-G provided nearly a 1.7 fold protection towards development of CAD. For MS gene, rs185087 was also found to be associated with CAD in a co-dominant (p = 0.003 and p = 0.03), dominant (p = 0.001) and allelic models (p = 0.001). The gene-gene interaction revealed strong epistasis between single nucleotide polymorphisms (SNPs), ESR1 rs9340799 and MTHFR rs2274976. Furthermore, the dendrogram for gene-environment dataset indicated moderately synergistic interaction between CETP rs708272 and physical inactivity. Conclusion: In the study under reference, a significant association of ESR1-XbaI (rs9340799), MTHFR C677T (rs1801133) and MS A2756G (rs185087) gene polymorphisms with the susceptibility of CAD in the population of Jammu region (JandK) has been observed.

show abstract

Section: Discussionsupporting

confidence: 91%

Association of ESR1 (rs2234693 and rs9340799), CETP (rs708272), MTHFR (rs1801133 and rs2274976) and MS (rs185087) polymorphisms with Coronary Artery Disease (CAD)

Raina

Sharma

Panjaliya

et al. 2020

BMC Cardiovasc Disord

View full text Add to dashboard Cite

show abstract

“…Regarding MTR gene, the present study has figured out higher frequency of G allele in cases than in controls. Similarly, Jemaa et al (2008) revealed significant and dependent association between the G allele of the MTR gene and MI in Tunisian population 63 . Huang and colleagues (2008), observed a striking difference between MTHFR (C677T), MTR (A2756G) gene polymorphisms and hyperlipidemia in Northern Chinese subjects 64 .…”

Section: Discussionmentioning

confidence: 94%

Methylenetetrahydrofolate reductase C677T and methionine synthase A2756G gene polymorphisms and associated risk of cardiovascular diseases: A study from Jammu region

Raina

Sharma

Panjaliya

et al. 2016

Indian Heart Journal

View full text Add to dashboard Cite

show abstract

“…However, the biochemical effects of MTR A2756G polymorphism have not been examined in vitro due to the inability to express human MTR at sufficient levels in an active form (Harmon et al 1999). Twenty-five studies have investigated the MTR-HCY association in healthy nonpregnant populations (Dekou et al 2001;Ma et al 1999;Silaste et al 2001;Klerk et al 2003;Chen et al 2001;Jacques et al 2003;Tsai et al 2009;Fredriksen et al 2007;Rodriguez-Oroz et al 2009;Harmon et al 1999;Bosco et al 2003;Chung et al 2010;D'Angelo et al 2000;de Lau et al 2010;DeVos et al 2008;Diwakar 2008;Fillon-Emery et al 2004;Geisel et al 2001;Holmes et al 2011;Jemaa et al 2008;Kluijtmans et al 2003;Naushad 2008;Palep-Singh et al 2008;Summers et al 2008Summers et al , 2010Yakub et al 2012). However, of the 25 studies, only 10 were conducted among a study population of greater than 100 participants with similar age distribution and ethnic background (Ma et al 1999;Klerk et al 2003;Chen et al 2001;Jacques et al 2003;Tsai et al 2009;Harmon et al 1999;D'Angelo et al 2000;Fillon-Emery et al 2004;Geisel et al 2001;Summers et al 2008); two of the 10 comparable studies support the association found in this research (Chen et al 2001;<...>…”

Section: Discussionmentioning

confidence: 99%

Effects of methionine synthase and methylenetetrahydrofolate reductase gene polymorphisms on markers of one-carbon metabolism

Massey

2013

Genes Nutr

View full text Add to dashboard Cite

Genetic and nutritional factors play a role in determining the functionality of the one-carbon (1C) metabolism cycle, a network of biochemical reactions critical to intracellular processes. Genes encoding enzymes for methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MTR) may determine biomarkers of the cycle including homocysteine (HCY), S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH). MTHFR C677T is an established genetic determinant of HCY but less is known of its effect on SAM and SAH. Conversely, the relationship between MTR A2756G and HCY remains inconclusive, and its effect on SAM and SAH has only been previously investigated in a female-specific population. Folate and vitamin B12 are essential substrate and cofactor of 1C metabolism; thus, consideration of gene-nutrient interactions may clarify the role of genetic determinants of HCY, SAM and SAH. This cross-sectional study included 570 healthy volunteers from Kingston, Ontario, Ottawa, Ontario and Halifax, Nova Scotia, Canada. Least squares regression was used to examine the effects of MTR and MTHFR polymorphisms on plasma HCY, SAM and SAH concentrations; gene-gene and gene-nutrient interactions were considered with the inclusion of cross-products in the model. Main effects of MTR and MTHFR polymorphisms on HCY concentrations were observed; however, no gene-gene or gene-nutrient interactions were found. No association was observed for SAM. For SAH, interactions between MTR and MTHFR polymorphisms, and MTHFR polymorphism and serum folate were found. The findings of this research provide evidence that HCY and SAH, biomarkers of 1C metabolism, are influenced by genetic and nutritional factors and their interactions.

show abstract

Association between the 2756A> G variant in the gene encoding methionine synthase and myocardial infarction in Tunisian patients

Abstract: The present study showed a significant but not independent association between the 2756A>G polymorphism of the MTR (presence of G allele) and MI in the Tunisian population.

Cited by 10 publications

References 21 publications

Association of ESR1 (rs2234693 and rs9340799), CETP (rs708272), MTHFR (rs1801133 and rs2274976) and MS (rs185087) polymorphisms with Coronary Artery Disease (CAD)

Association of ESR1 (rs2234693 and rs9340799), CETP (rs708272), MTHFR (rs1801133 and rs2274976) and MS (rs185087) polymorphisms with Coronary Artery Disease (CAD)

Methylenetetrahydrofolate reductase C677T and methionine synthase A2756G gene polymorphisms and associated risk of cardiovascular diseases: A study from Jammu region

Effects of methionine synthase and methylenetetrahydrofolate reductase gene polymorphisms on markers of one-carbon metabolism

Contact Info

Product

Resources

About