Association between the -174 G/C polymorphism of the interleukin-6 gene and myocardial infarction risk: a meta-analysis

Zhou, Jing; Jiang, Feng; Li, X

doi:10.4238/gmr.15038358

Cited by 5 publications

(5 citation statements)

References 19 publications

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“…Several studies have reported an association between the IL-6 gene (-174G>C) polymorphism and CAD, HF [13,14]. However, other studies have reported no such relation [15][16][17][18].…”

Section: Resultsmentioning

confidence: 99%

Relationship Between Interleukin-6 Gene Polymorphism and Heart Failure in Patients With Coronary Artery Disease and Obesity

et al. 2020

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The aim: To examine the association between polymorphisms of the IL-6 gene promoter and HF in patients with CAD and obesity. Material and methods: 222 patients with coronary artery disease and obesity were identified. Comparison group consisted of 115 patients with coronary artery disease with normal body weight. The groups were comparable in age and sex. The exclusion group consisted of patients with severe concomitant diseases of the respiratory and digestive organs, kidneys and people with cancer. One single nucleotide polymorphisms in the interleukin-6 promoter region was analyzed. Odds ratio (OR) and 95 % confident interval (95 % CI) were calculated. Results: The combined course of coronary artery disease and obesity was characterized by the detection of allele C in 62 patients (27.93 %), allele G – in 160 patients (72.07 %), and genotypes CC, CG and GG – at 24 (10.81 %), 67 (30.18 %) and 131 (59.01 %) patients respectively. The results showed that the −174G allele and GG genotype in patients with coronary artery disease and obesity were associated with heart failure (OR = 2.55, 95% CI = [1.72-3.79], χ2 = 22.8; p<0.05) and (OR = 11.95, 95% CI = [3.41-41.91], χ2 = 22.5; p<0.05), whereas allele C−174 was associated with a decrease in the risk of heart failure (OR = 0.39, 95% CI = [0.26-0.58 ], χ2 = 22.75, p<0.05). Conclusions: The obtained results testify that the −174G>C polymorphism in the interleukin-6 gene is significantly associated with increased risk of heart failure in patients with coronary artery disease and obesity.

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“…Several studies have reported an association between the IL-6 gene (-174G>C) polymorphism and CAD, HF [13,14]. However, other studies have reported no such relation [15][16][17][18].…”

Section: Resultsmentioning

confidence: 99%

Relationship Between Interleukin-6 Gene Polymorphism and Heart Failure in Patients With Coronary Artery Disease and Obesity

et al. 2020

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“…Также IL-6 активирует эндотелий, провоцирует рекрутинг лейкоцитов в сосудистой стенке и стимулирует пролиферацию гладкомышечных клеток, способствуя прогрессированию роста атеросклеротической бляшки и развитию ее неста-бильности. Противовоспалительное действие заключается в том, что он может блокировать апоптоз кардиомиоцитов [18,19]. Ген IL-6 расположен в хромосомном сегменте 7p21, состоит из пяти экзонов.…”

Section: клеточно-молекулярные основы постинфарктного по вреждения сеunclassified

“…Противоречивы также результаты метаанализов. Так, в работе Zhou J, et al (2016), в которую было включено 9 исследований, ассоциация -174 G/C и ИМ не подтверждается [18]. В то же время в метаанализе 11 исследований Yuanzhe Jin (2014), наличие ассоциации подтверждается: полиморфизм -174 G/C связан с повышенным риском развития ИМ.…”

Section: клеточно-молекулярные основы постинфарктного по вреждения сеunclassified

Some pro- and anti-inflammatory cytokines, their genetic polymorphism and postinfarct cardiac remodeling

2020

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The role of molecular genetic factors in cardiovascular disease (CVD) development has been actively studied in recent years. In patients with acute myocardial infarction and heart failure, the genetic component contributes to the determination of inflammation and persistence of inflammatory mediators in the myocardium. The genetic component in combination with traditional CVD risk factors determines the clinical course of the disease, the severity and its outcome. This review summarizes the data on relationship of proand anti-inflammatory cytokines with coronary artery disease and its clinical manifestations.

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“…It not only overcomes the drawbacks of small sample size and inadequate statistical power of genetic studies with complicated characteristics, but also provides more convincing conclusions compared to a single study. 8 Thus, in this research study, a meta-analysis was conducted by enrolling eligible studies to assess the relationship between IL-6-174G/C and -572G/C polymorphisms and sepsis.…”

Section: Introductionmentioning

confidence: 99%

Association between IL-6 polymorphisms and sepsis

Chen

Pang

et al. 2019

Innate Immun

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The aim of the present study was to determine whether IL-6 polymorphisms correlate with sepsis. According to the inclusion criteria, the association of IL-6 polymorphisms with sepsis was searched in databases and analysed using comprehensive meta-analysis software. A total of 16 studies were included in this meta-analysis. There was no significant association between the IL-6-174G/C polymorphism and sepsis risk in the total population (C vs. G: OR = 1.04, 95% CI = 0.79–1.38; CC vs. GG: OR = 0.86, 95% CI = 0.53–1.41; CG vs. GG: OR = 0.99, 95% CI = 0.79–1.24; dominant model: OR = 0.97, 95% CI = 0.74–1.29; recessive model: OR = 0.92, 95% CI = 0.61–1.39). When patients were stratified according to ethnicity, a statistically significant association was observed in Asians and Africans. As for the -572G/C polymorphism, the results showed that the IL-6-572C/G polymorphism was not associated with sepsis susceptibility (G vs. C: OR = 0.98, 95% CI = 0.79–1.22; GG vs. CC: OR = 1.46, 95% CI = 0.53–4.03; GC vs. CC: OR = 0.82, 95% CI = 0.54–1.27; dominant model: OR = 0.88, 95% CI = 0.55–1.41; recessive model: OR = 1.55, 95% CI = 0.82–2.92). The data indicated that the IL-6-174G/C polymorphism may contribute to sepsis risk, especially in Africans and Asians. No significant association was observed between the IL-6-572G/C polymorphism and sepsis risk.

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Association between the -174 G/C polymorphism of the interleukin-6 gene and myocardial infarction risk: a meta-analysis

Cited by 5 publications

References 19 publications

Relationship Between Interleukin-6 Gene Polymorphism and Heart Failure in Patients With Coronary Artery Disease and Obesity

Relationship Between Interleukin-6 Gene Polymorphism and Heart Failure in Patients With Coronary Artery Disease and Obesity

Some pro- and anti-inflammatory cytokines, their genetic polymorphism and postinfarct cardiac remodeling

Association between IL-6 polymorphisms and sepsis

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