Association between TGFB1 915G/C polymorphism and susceptibility to chronic hepatitis C virus infection: A meta-analysis

Hu, Guorui; Zheng, Bixia; Liu, Zhifeng

doi:10.3892/br.2014.230

Cited by 4 publications

(2 citation statements)

References 41 publications

(67 reference statements)

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“…This mechanism may result in the correlation of the polymorphism of codon 25G/C and chronic HCV infection. However, one previous meta-analysis demonstrated that the polymorphism of TGF-β1 codon 25G/C wasn’t correlated with the chronic HCV infection [31]. In our proposed meta-analysis, the summary results were obtained by pooling the data from the latest and most complete studies and conducting the total analysis, subgroup analyses and the different comparison of controls analyses.…”

Section: Discussionmentioning

confidence: 99%

Association of TGF-ß1 polymorphisms and chronic hepatitis C infection: a Meta-analysis

et al. 2019

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Background Although several researches have reported the connection between the transforming growth factor-beta 1 ( TGF-β1 ) gene polymorphisms and chronic hepatitis C virus (HCV) infection, the conclusions of these studies were not always consistent. Here, this paper proposed a meta-analysis to evaluate whether the TGF-ß1 gene polymorphisms, −509C/T (rs1800469), codon 10 T/C (rs1982073) and codon 25G/C (rs1800471), were associated with chronic HCV infection. Methods The summary odds ratios (ORs) of chronic HCV infected patients and controls with all SNPs were obtained by adaptive fixed or random effect model. A series of statistical tools were employed to guarantee the accuracy of related pooling ORs, including the Hardy-Weinberg equilibrium (HWE) test, sensitivity analysis and publication bias test. Results This paper analyzed 18 case-control studies in 17 articles which totally contains 2718 chronic HCV infection cases corresponding to 1964 controls. The results of the meta-analysis indicated that the −509C/T polymorphism effected an increased risk of chronic HCV infection in all gene models. More specifically by ethnicity stratification, the Egyptians shared the similar association with the above overall study. Moreover, the meta-fusion of healthy control studies showed that − 509 T allele carriers (TT + TA) had nearly 2.00 and 3.36 fold higher risk of chronic HCV infection in the total and Egyptian populations, respectively (OR = 2.004, 95% CI = 1.138–3.528, P = 0.016; OR = 3.363, 95% CI = 1.477–7.655, P = 0.004, respectively). However, our meta-analysis did not find any significant association between the codon 10 T/C or codon 25G/C polymorphisms and chronic HCV infection. Conclusions Our results suggested that the TGF-ß1 –509C/T polymorphism may effect an increased risk of chronic HCV infection, especially in Egyptian population. Electronic supplementary material The online version of this article (10.1186/s12879-019-4390-8) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Association of TGF-ß1 polymorphisms and chronic hepatitis C infection: a Meta-analysis

et al. 2019

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“…The action of cytokines can result in anti- or pro-inflammatory effects and growth stimulation or inhibition [ 12 ]. Several studies have shown that the host genetic factor plays a significant role in this immune response and the outcome of HCV infection [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Cytokine (IL-10, IL-6, TNF-α and TGF-β1) Gene Polymorphisms in Chronic Hepatitis C Virus Infection among Malay Male Drug Abusers

et al. 2021

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Cytokines play an important role in modulating inflammation during viral infection, including hepatitis C virus (HCV) infection. Genetic polymorphisms of cytokines can alter the immune response against this infection. The objective of this study was to investigate the possible association between chronic hepatitis C virus infection susceptibility and cytokine gene polymorphism for interleukin-10 (IL-10) rs1800896 and rs1800871, interleukin 6 (IL-6) rs1800795, TNF-α rs1800629, and TGF-β1 rs1800471 in Malay male drug abusers. The study was conducted on 76 HCV-positive (HP) male drug abusers and 40 controls (HCV-negative male drug abusers). We found that there were significant differences in the frequencies of genotype for IL-10 rs1800871 (p = 0.0386) and at the allelic level for IL-10 rs1800896 A versus G allele (p = 0.0142) between the HP group and the control group. However, there were no significant differences in gene polymorphism in interleukin 6 rs1800795, TNF-α rs1800629 and TGF-β1 rs1800471. These findings suggest significant associations between gene polymorphism for IL-10 rs1800871, IL-10 rs1800896 (at the allelic level) and susceptibility to HCV infection among Malay male drug abusers.

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Common ABCB1 polymorphisms in Greek patients with chronic hepatitis C infection: A comparison with hyperlipidemic patients and the general population

Gbandi

Goulas

Sevastianos

et al. 2016

Pharmacological Reports

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Association between TGFB1 915G/C polymorphism and susceptibility to chronic hepatitis C virus infection: A meta-analysis

Cited by 4 publications

References 41 publications

Association of TGF-ß1 polymorphisms and chronic hepatitis C infection: a Meta-analysis

Association of TGF-ß1 polymorphisms and chronic hepatitis C infection: a Meta-analysis

Cytokine (IL-10, IL-6, TNF-α and TGF-β1) Gene Polymorphisms in Chronic Hepatitis C Virus Infection among Malay Male Drug Abusers

Common ABCB1 polymorphisms in Greek patients with chronic hepatitis C infection: A comparison with hyperlipidemic patients and the general population

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