Association between TGF-β1 rs1982073/rs1800469 polymorphism and lung cancer susceptibility

Chen, Guangyuan; Hu, Cong; Lai, Penghui; Song, Yuxuan; Xiu, Mengxi; Zhang, Haifei; Zhang, Shujun; Huang, Peng

doi:10.1097/md.0000000000018028

Cited by 12 publications

(11 citation statements)

References 23 publications

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“…Similarly, for C509T polymorphism, no significant association was found for breast cancer risk [27]. Another study done by Chen et al concluded that the TGFB1 T869C (rs1800470) and C509T (rs1800469) polymorphisms were not associated with lung cancer development and revealed the C509T (rs1800469) polymorphism diminishes the danger of lung cancer growth in patients with non-small cell lung cancer (NSCLC) [14]. Furthermore, a meta analysis study reported that in people of Asian ethnicity, C509T polymorphism was associated with lower risk of breast and gastric cancer, whereas, T869C polymorphism showed higher risk of developing cancer in Caucasian population but not in Asian people [28].…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, reports of elevated expression of TGFB1 protein in patients with cervical adenocarcinoma are also available [12]. Polymorphisms of TGFB1 gene has been reported in different types of cancer including lung cancer and colorectal cancer [13,14] but its relation to the risk of developing cervical cancer in Bangladeshi population is not yet available.…”

Section: Introductionmentioning

confidence: 99%

“…The C509T (rs1800469) and T869C (rs1800470) are the two most common polymorphisms of TGFB1 gene that have been linked with lung cancer, colorectal cancer and gastric cancer [13,14,18]. C509T polymorphism is located in the promoter site of the TGFB1 gene and a previous study reported individuals homozygous for T allele had nearly double plasma TGFB1 protein level compared to homozygous wild type C allele carriers [19].…”

Section: Introductionmentioning

confidence: 99%

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Association of TGFB1 gene polymorphisms with cervical cancer in Bangladeshi women: A case-control study

Apu

Aktar

Rahman

et al. 2021

TUB

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OBJECTIVES: Genetic susceptibility to cervical cancer in relation to transforming growth factor beta 1 (TGFB1) gene polymorphisms has not been investigated extensively among the women in Bangladesh. So, the aim of this study was to find out the correlation of the polymorphisms of TGFB1 C509T (rs1800469) and T869C (rs1800470) with the risk of cervical cancer among the Bangladeshi women. STUDY DESIGN: 134 cervical cancer patients and 102 age-sex matched healthy controls were included from two institutions in Bangladesh. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used for genotyping two TGFB1 single nucleotide polymorphisms C509T (rs1800469) and T869C (rs1800470) in patients and controls. RESULTS: No significant correlation was found between polymorphisms C509T (rs1800469) and T869C (rs1800470) of TGFB1 gene with cervical cancer in Bangladeshi women. In case of the cervical cancer patients who had first degree relatives with cancer were prone to carry the polymorphic version of the TGFB1 gene polymorphism at C509T (OR = 5.597, 95% CI = 1.224–25.597, p < 0.05) but may not result in the increase of developing cervical cancer. CONCLUSION: In summary, two polymorphisms C509T and T869C of TGFB1 gene may not be associated with cervical cancer risk in Bangladeshi women.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of TGFB1 gene polymorphisms with cervical cancer in Bangladeshi women: A case-control study

Apu

Aktar

Rahman

et al. 2021

TUB

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“…Individuals with the TT genotype have a slightly lower incidence of lung cancer compared to individuals with the other genotypes, suggesting a possible protective role of the TT variant for lung cancer susceptibility in patients with NSCLC. (Chen et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Relation of TGF-β1 gene with the prognosis of patients with Covid-19

Carminati

Carneiro

Cunha

et al. 2022

RSD

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This study aimed to investigate the role of the TGF-β1 gene in SARS-CoV-2 infection. A total of 178 individuals diagnosed with Covid-19 participated and, they were divided in two groups related to the outcome (discharge or death). Genotyping of rs1800468 and rs1800469 polymorphisms of TGF-β1 gene was performed in 178 samples, using the allelic discrimination technique and, gene expression analysis was performed in 93 samples by Real Time PCR. There was no association between the genotypic frequencies of TGF-β1 gene polymorphisms analyzed with the prognosis of patients with Covid-19. There was no significant difference between gene expression and the clinical data evaluated. A statistically significant difference was observed in the expression of the TGF-β1 gene between the CT and TT genotypes of the rs1800469 polymorphism, with lower gene expression in the presence of the TT genotype. Regarding the rs1800468 polymorphism, no statistically significant difference was observed in the expression of the TGF-β1 gene in relation to the analyzed genotypes. The present study concluded that the rs1800468 and rs1800469 polymorphisms of the TGF-β1 gene are not associated with the prognosis of patients with Covid-19 and which the TT genotype of the rs1800469 polymorphism reduces the expression of TGF-β1.

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“…Lung cancer is mainly caused by smoking and other environmental factors, such as exposure to heavy metals, radiation, asbestos, and air pollution ( 3 ). However, even if exposed to these factors, only a small portion of people suffer from lung cancer, which indicates that genetic factors also play an important role in the occurrence of lung cancer ( 4 ). The current view is that the occurrence and development of lung cancer is the result of the interaction between environment and heredity ( 4 , 5 ).…”

Section: Introductionmentioning

confidence: 99%

Association Between NAT2 Polymorphism and Lung Cancer Risk: A Systematic Review and Meta-Analysis

Zhu

Xu²,

Xia

et al. 2021

Front. Oncol.

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Lung cancer is the leading cause of cancer-related death worldwide and has a high incidence rate. N-Acetyltransferase 2 (NAT2) is a polymorphic xenobiotic enzyme, which can catalyze N-acetylation and O-acetylation of various carcinogens such as aromatic, heterocyclic amines and hydrazines. At present, many studies have explored the effects of NAT2 polymorphism on lung cancer, but we found inconsistent results. We researched 18 published studies, involving 4,016 patients and 5,469 controls, to more accurately assess the effects of NAT2 polymorphism on lung cancer risk and to investigate whether smoking is associated. We used STATA software to analyze the extracted data and used STATA for subgroup analysis, sensitivity analysis, and to perform publication bias tests. To determine the correlation, we used the crude odds ratio (ORs) with 95% confidence interval (CIs). Our study was prospectively registered in PROSPERO (CRD42020159737). The odds ratio was 1.53 (95% CI: 1.21–1.95, I² = 45.2%, P=0.104) for the NAT2 slow + intermediate phenotype versus rapid phenotype. The results suggested that people with NAT2 non-rapid (slow + intermediate) phenotype have a significantly increased risk of lung cancer. In addition, NAT2 rapid phenotype was significantly associated with reduced risk of lung cancer, compared with slow phenotype or intermediate phenotype (slow phenotype vs. rapid phenotype: OR: 1.61, 95% CI: 1.07–2.42, I²= 50%, P= 0.075; intermediate phenotype vs. rapid phenotype: OR: 1.47, 95% CI: 1.15–1.88, I²= 40.3%, P= 0.137).

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Association between TGF-β1 rs1982073/rs1800469 polymorphism and lung cancer susceptibility

Cited by 12 publications

References 23 publications

Association of TGFB1 gene polymorphisms with cervical cancer in Bangladeshi women: A case-control study

Association of TGFB1 gene polymorphisms with cervical cancer in Bangladeshi women: A case-control study

Relation of TGF-β1 gene with the prognosis of patients with Covid-19

Association Between NAT2 Polymorphism and Lung Cancer Risk: A Systematic Review and Meta-Analysis

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