Association between testosterone levels and the metabolic syndrome in adult men

Grosman, Halina; Rosales, Mónica; Fabre, Bibiana; Nolazco, Carlos; Mazza, Osvaldo; Berg, Gabriela; Mesch,

doi:10.3109/13685538.2014.913561

Cited by 31 publications

(21 citation statements)

References 40 publications

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“…Both were induced solely by the treatment with CAB, therefore suggesting an effect of the decrease in PRL and the increase in testosterone levels on the metabolic improvement. On the other hand, the negative impact of testosterone deficiency on the body composition and visceral obesity [5,6,7,8,9,15] is confirmed in the current series, since testosterone has been found to be inversely correlated to weight, BMI and WC, and particularly so in the HG patients, whose weight, BMI and WC were significantly higher than those in the non-HG subjects at both evaluations. Men with testosterone and DHT levels in the lower quartiles have been found to have more than 2-fold higher odds of exhibiting MetS [73], and testosterone and DHT have been proposed as potential biomarkers of MetS which are not causally related to the MetS onset over time [73].…”

Section: Discussionsupporting

confidence: 65%

“…Indeed, testosterone has been demonstrated to regulate body composition and metabolic profile [5,6,7,8,9]. In healthy subjects, testosterone levels have been found to be inversely correlated with waist circumference (WC) [5,6,7,8,9], a surrogate clinical marker of visceral obesity, and with the amount of visceral adipose tissue [10,11,12]. On the other hand, testosterone clearly influences insulin sensitivity.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Chronic Cabergoline Treatment and Testosterone Replacement on Metabolism in Male Patients with Prolactinomas

et al. 2015

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Introduction: Hyperprolactinemia and hypogonadism are reportedly associated with an impaired metabolic profile. The current study aimed at investigating the effects of testosterone replacement and cabergoline (CAB) treatment on the metabolic profile in male hyperprolactinemic patients. Patients and Methods: Thirty-two men with prolactinomas, including 22 with total testosterone (TT) <8 nmol/l (HG, 69%) and 10 with TT >8 nmol/l (non-HG, 31%), were entered in the study. In all patients, metabolic parameters were assessed at diagnosis and after 12- and 24-month treatment. Results: Compared to non-HG patients, at baseline the HG patients had higher waist circumference (WC). TT significantly correlated with body mass index (BMI). Twelve-month CAB induced PRL normalization in 84%. HG prevalence significantly decreased (28%) and non-HG prevalence significantly increased (72%). Anthropometric and lipid parameters, fasting insulin (FI), insulin sensitivity index (ISI₀), homeostatic model assessment of insulin secretion (HOMA-β) and homeostatic model assessment of insulin resistance (HOMA-IR) significantly improved compared to baseline. TT was the best predictor for FI. Percent change (Δ) of TT significantly correlated with ΔCholesterol, ΔWeight and ΔBMI. Compared to non-HG patients, the HG patients had a higher weight, BMI, WC and HOMA-β. In HG, testosterone replacement was started. After 24 months, PRL normalized in 97%. HG prevalence significantly decreased (6%) and non-HG prevalence significantly increased (94%). Anthropometric and lipid parameters, FI, ISI₀, HOMA-β and HOMA-IR significantly improved compared to baseline, with FI, ISI₀, HOMA-β and HOMA-IR further ameliorating compared to the 12-month evaluation. Compared to non-HG patients, the HG patients still had a higher weight, BMI and WC. Conclusions: In hyperprolactinemic hypogonal men, proper testosterone replacement induces a significant improvement in the metabolic profile, even though the amelioration in the lipid profile might reflect the direct action of CAB.

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Section: Discussionsupporting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Effect of Chronic Cabergoline Treatment and Testosterone Replacement on Metabolism in Male Patients with Prolactinomas

et al. 2015

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“…The association with low HDL and hypertension has been more variable. A cross sectional analysis in men 45-70 years old showed T correlated positively with HDL and four of five components of metabolic syndrome (18), while another study of males with a mean age of 52 years found no association between serum T and hypertension or HDL (19). Our analysis contradicts prior cross-sectional studies that found a negative association of T with cIMT.…”

Section: Discussionmentioning

confidence: 69%

Endogenous Testosterone and its Relationship to Preclinical and Clinical Measures of Cardiovascular Disease in the Atherosclerosis Risk in Communities Study

Srinath

Golden

Carson

et al. 2015

The Journal of Clinical Endocrinology &Amp; Metabolism

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“…Only TGs showed differences between men and women of the respective groups, which could be attributed to their testosterone (T) levels. This is quite likely since a study by Grosman et al [24] found a significant but weak negative correlation between TG levels and T concentrations. In the aforementioned study, the prevalence of the MetS also increased as T levels became lower, suggesting that the men with the MetS will have lower T levels and in turn higher TG levels.…”

Section: Discussionmentioning

confidence: 95%

The prevalence of the metabolic syndrome in a farm worker community in the Boland district, South Africa

Kruger

Nell

2017

BMC Public Health

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BackgroundIn South Africa, not much is known about MetS in farm working communities. This study aimed to describe the prevalence of the MetS in a farm working population from the Boland winelands district of the Western Cape, South Africa.MethodsA cross-sectional study was followed among farm workers (aged 20–60 years) from surrounding wine estates. The questionnaires used described socio-demographic status, ethnic background, alcohol consumption, smoking, exercise and daily medication. Anthropometric assessments were performed and blood pressure measurements taken prior to blood sampling for serum insulin, glucose and fasting lipogram profiles.ResultsThe prevalence of the MetS was higher in women (46.3 vs 29.3%). Both men and women in the MetS group had a significantly higher waist circumferences (WC; p < 0.001 for both), whilst higher glucose levels were only significantly higher in the women (p < 0.001). Correlations showed significant differences between body mass index (BMI), WC and waist to hip ratio (W:H) and the different MetS risk factors.ConclusionsThe female population in this study showed higher prevalence rates for the individual risk factors and the MetS overall. There is an urgent need to develop culturally sensitive health promotion programs addressing risk factors for metabolic syndrome among farm workers.

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Association between testosterone levels and the metabolic syndrome in adult men

Cited by 31 publications

References 40 publications

Effect of Chronic Cabergoline Treatment and Testosterone Replacement on Metabolism in Male Patients with Prolactinomas

Effect of Chronic Cabergoline Treatment and Testosterone Replacement on Metabolism in Male Patients with Prolactinomas

Endogenous Testosterone and its Relationship to Preclinical and Clinical Measures of Cardiovascular Disease in the Atherosclerosis Risk in Communities Study

The prevalence of the metabolic syndrome in a farm worker community in the Boland district, South Africa

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