Association between telomere length and diabetes mellitus: A meta-analysis

Abstract

ObjectiveWe investigated the relationship between diabetes and telomere length by meta-analysis.MethodsWe searched five popular databases for articles published between 1990 and 2015 using “diabetes” and “telomere” as search terms. Data were processed with RevMan5, and random- or fixed-effects meta-analysis was applied. The effects of geographical region, diabetes type, body mass index (BMI), age and sex were examined. Funnel plots were applied to evaluate publication bias.ResultsSeventeen articles were obtained from 571 references. We identified a significant association between telomere length and diabetes mellitus (standardized mean difference [SMD]: −3.41; 95% confidence interval [CI]: −4.01, −2.80; heterogeneity, I2 = 99%) by comparing 5575 patients with diabetes and 6349 healthy individuals. The pooled SMD by geographic region indicated a significant association between shortened telomere length and diabetes mellitus (SMD: −3.41; 95% CI: −4.01, −2.80; heterogeneity, I2 = 99%). In addition, telomere length was significantly associated with age (SMD: −3.41; 95% CI: −4.01, −2.80), diabetes type (SMD: −3.41; 95% CI: −4.01, −2.80), BMI (SMD: −1.61; 95% CI: −1.98, −1.23) and sex (SMD: −4.94; 95% CI: −9.47, −0.40).ConclusionsThe study demonstrated a close relationship between diabetes mellitus and telomere length, which was influenced by region, age, diabetes type, BMI and sex.

The role of senescence, telomere dysfunction and shelterin in vascular aging

“…In clinical studies, correlations have been made between leukocyte telomere length and age-related chronic diseases, with telomere length of leukocytes regarded as a reliable marker for prognosis in cancer and type 2 diabetes, although it varies between individuals. 34,35 However, in the setting of coronary artery disease, leukocyte telomere length is a poor predictor of clinical outcome and is independent of conventional vascular risk factors. 36 While the telomere length of leukocytes is typically shorter with aging and age-related chronic disease, this could be due to chronic inflammation induction of leukocyte proliferation and not advanced age per se.…”

“…In clinical studies, correlations have been made between leukocyte telomere length and age‐related chronic diseases, with telomere length of leukocytes regarded as a reliable marker for prognosis in cancer and type 2 diabetes, although it varies between individuals . However, in the setting of coronary artery disease, leukocyte telomere length is a poor predictor of clinical outcome and is independent of conventional vascular risk factors .…”

Aerobic capacity and telomere length in human skeletal muscle and leukocytes across the lifespan

“…Literature is inconsistent regarding TL and all-cause mortality with some [7,15] but not all studies [16,17] finding that a shorter TL is associated with increased risk of all-cause mortality. Some studies show that a shorter TL is associated with age-related conditions such as cardiovascular disease [18,19] and diabetes mellitus [9,20]. While in cancer the literature is conflicted regarding risk of cancer and TL [7,[21][22][23] with suggestions that perhaps a "Ushaped" risk association may exist between very short and very long telomeres and risk of different types cancer [12,22,24,25].…”

Association between leukocyte telomere length and specific antibody levels after vaccination against tick-borne encephalitis

“…По-видимому, этот эффект связан с меньшим распространением среди женщин курения и злоупотребления алкоголем, которые приводят к укорочению длины теломер (Freitas-Simoes et al, 2016;Astuti et al, 2017). Другие исследователи обнаружили, что ассоциация длины теломер с сахарным диабетом (Wang et al, 2016) или социальным стрессом (Willis et al, 2018) также зависит от пола. Ранее нами были выявлены противоположные корреля ции длины теломер с объемом талии у мужчин и женщин (Максимов и др., 2016).…”