Background
Anti-tumor necrosis factor (TNF) agents are an important component of inflammatory bowel disease (IBD) treatment but data on their influence on anemia, a frequent complication of IBD is limited. The aim of this study was to evaluate the effect of anti-TNF agents on hemoglobin (Hb) levels in a large IBD cohort.
Methods
Prospectively collected demographic, clinical, laboratory and treatment data from IBD patients who started anti-TNF treatment at a tertiary referral center during the years 2010–2012 were analyzed. Follow-up data including disease activity scores (Harvey-Bradshaw Index or ulcerative colitis activity index), quality of life scores [short IBD questionnaire (SIBDQ)] completed at each visit, and laboratory data were analyzed. Data from the year of anti-TNF initiation (year 0) and the following year (year 1) were compared.
Results
A total of 430 IBD patients (324 with Crohn’s disease, 51.6% females) started anti-TNF treatment. The prevalence of anemia and median Hb levels did not change between year 0 and year 1. Median SIBDQ was significantly improved at year 1 (p=0.002). IBD patients with anemia had significantly higher median Hb levels at year 1 compared to year 0 (p=0.0009). Hematopoietic response (increase of Hb ≥2 g/dL) was observed in only 33.6 % of the 134 anemic IBD patients, despite iron replacement being administered in 126 anemic patients (oral 77 %). Improvement in Hb levels was independently significantly correlated with change of CRP levels (p=0.04) and immunomodulators use (p=0.03).
Conclusion
Anemia remains a significant manifestation of IBD one year after treatment with anti-TNF agents.