Association between systemic immune-inflammation index and low muscle mass in US adults: a cross-sectional study

Shi, Lin; Zhang, Liang; Zhang, Dan; Chen, Zhuo

doi:10.1186/s12889-023-16338-8

Cited by 13 publications

(7 citation statements)

References 48 publications

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“…According to previous literature, the relationship between physical activity and sarcopenia may be related to inflammation. Inflammation is a well-known factor contributing to sarcopenia progression 34 – 36 . In exercised muscle, inflammatory cytokines such as IL-6 recruit immune cells and produce IL-10 receptor antagonists decreasing inflammatory injury 37 .…”

Section: Discussionmentioning

confidence: 99%

Associations between life’s essential 8 and sarcopenia in US adults: a cross-sectional analysis

Long,

Zou,

Dong

2024

Sci Rep

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Cardiovascular disease (CVD) is closely associated with sarcopenia. We aimed to examine the relationship between Life’s Essential 8 (LE8) and the incidence of sarcopenia among adults in the United States. In this study, a cross-sectional analysis was conducted using data from the National Health and Nutrition Examination Survey from 2013 to 2018 and included 5999 adult participants. LE8 score was categorized into low (< 49), moderate (49–79), and high CVH (≥ 79) groups and consisted of health behavior score and health factor score based on American Heart Association definitions. Sarcopenia was defined according to The Foundation for the National Institutes of Health Sarcopenia Project. Multivariate logistic regressions, restricted cubic spline regressions, and subgroup analyses were used to assess the association between LE8 and sarcopenia. LE8 and its subscales score were negatively associated with the incidence of sarcopenia in US adults.

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Section: Discussionmentioning

confidence: 99%

Associations between life’s essential 8 and sarcopenia in US adults: a cross-sectional analysis

Long,

Zou,

Dong

2024

Sci Rep

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“… 35 Studies have also indicated that higher values of PLR, NLR, SII, and SIRI, and lower LMR values are closely associated with higher prevalence of sarcopenia in populations aged 50 or older in China, as well as an increased SII value in a large population aged 20 years and over is associated with a higher risk of low muscle mass in the United States. 17 , 36 , 37 …”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Nutritional Risk Index and Other Indices for Predicting Sarcopenia in the Middle-Aged and Elderly Population of China Without Cancer: A ROC Curve Analysis

Zou,

Li,

Wang

et al. 2024

IJGM

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Background Emerging evidence suggests that systemic inflammatory and nutritional biomarkers, along with derived indices, could serve as predictors for sarcopenia in cancer population. This study aimed to compare these predictors, focusing on the nutritional risk index (NRI) and evaluate its diagnostic value, for sarcopenic patients without cancer. Methods This cross-sectional retrospective study included 1674 participants. Sarcopenia is defined by skeletal muscle mass index (SMI). Laboratory data reflected the values of systemic inflammatory and nutritional biomarkers, from which the derived indices were calculated. Multiple logistic regression analysis, ROC curve analysis, and the Youden index were utilized to assess the association between these markers and sarcopenia and determine the cutoff value for predicting sarcopenia. Results Among all participants (1110 men and 564 women, mean age 61.97 ± 9.83 years), 398 individuals were diagnosed with sarcopenia, indicating a prevalence of 23.78% in China’s middle-aged and elderly population without cancer. Logistic regression analysis revealed significant associations between all biomarkers and derived indices with sarcopenia. Following adjustment for potential confounders, lower NRI values were significantly associated with a higher incidence of sarcopenia. For sarcopenia diagnosis, the area under the curve (AUC) for NRI was 0.769 ([95% CI, 0.742, 0.796], P < 0.001), with a cutoff value of 106.016, sensitivity of 75.6% and specificity of 66.1%. NRI demonstrated greater predictive advantage for sarcopenia incidence in men compared to women. Conclusion A lower NRI value was associated with a higher prevalence of sarcopenia. NRI shows promise for early, rapid, and effective sarcopenia screening, particularly in China’s middle-aged and elderly male population without cancer.

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“…The systemic immune-inflammatory index (SII) was initially described as a potential marker for tumor and cardiovascular disease. [ 10 – 12 ] It is calculated as the platelet count multiplied by the neutrophil count and then divided by the lymphocyte count. [ 13 , 14 ] SII has been recognized as a better indicator of inflammation status.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of the systemic immuno-inflammatory index in critically ill patients with vertebral fractures

Zhang,

Li,

et al. 2024

Medicine

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Inflammation plays a critical role in vertebral fractures. However, there is a lack of sufficient evidence regarding the prognostic significance of the systemic immuno-inflammatory index (SII), a novel marker of systemic inflammation, in patients with vertebral fractures. In this study, we aimed to assess the predictive value of SII in critically ill patients with vertebral fractures. The data were from the Medical Information Mart for Intensive Care III (MIMIC-III) version 1.4 and Wenzhou Hospital of Traditional Chinese Medicine. The cutoff values for SII were determined using the receiver operating characteristic curve, and the subjects were grouped accordingly. The clinical outcome measured was mortality within 30 days, 90 days, or 1 year. The following formula was used to calculate the SII: SII = (platelet count) × (neutrophil count)/ (lymphocyte count). Cox proportional-hazard models were employed to assess the relationship between SII and survival. Additionally, propensity score matching analysis and COX models were utilized to examine the association between SII and survival outcomes. The Pearson correlation test confirmed the correlation between SII and vertebral T-values measured by bone mineral density and pain indicator. A total of 354 patients were finally included from MIMIC-III in the univariate analysis, for the 30-day mortality, SII ≥ 3164 group, the hazard ratio (HR) (95% confidence interval) was 1.71 (1.01, 2.94). After adjusting for age, gender, race, anion gap, creatinine, systolic blood pressure (SBP), DBP MBP, SOFA, acute physiologic score III, chronic kidney disease, and SAPS II, SII ≥ 3164 was found to be an independent significant risk factor for death in patients (HR = 1.85, 95% CI: 1.06–3.24, P = .0315). A similar trend was observed for 90-day mortality and 1-year mortality. Propensity scores matching analysis further confirmed the association of SII and the prognosis of patients. Our validation results were consistent with it. Besides, the Pearson correlation test confirmed a significant correlation between SII and vertebral T-values measured by bone mineral density and pain indicator. The study findings revealed that SII is an independent predictor of mortality in patients with vertebral fractures. This indicates that SII can serve as a reliable and easily accessible prognostic indicator for newly diagnosed critically ill patients with vertebral fractures.

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Association between systemic immune-inflammation index and low muscle mass in US adults: a cross-sectional study

Cited by 13 publications

References 48 publications

Associations between life’s essential 8 and sarcopenia in US adults: a cross-sectional analysis

Associations between life’s essential 8 and sarcopenia in US adults: a cross-sectional analysis

Diagnostic Value of Nutritional Risk Index and Other Indices for Predicting Sarcopenia in the Middle-Aged and Elderly Population of China Without Cancer: A ROC Curve Analysis

Prognostic value of the systemic immuno-inflammatory index in critically ill patients with vertebral fractures

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