Association Between Survivin Gene Promoter −31 C/G Polymorphism and Urothelial Carcinoma Risk in Taiwanese Population

Wang, Yuan Hung; Chiou, Hung Yi; Lin, Chih‐Wei; Hsieh, He-Yen; Wu, Chia Chang; Hsu, Cheng Da; Shen, Cheng

doi:10.1016/j.urology.2008.09.048

Cited by 51 publications

(50 citation statements)

References 25 publications

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“…The data are mostly compatible with data obtained in studies of lung and other cancers, suggesting that the C allele may be a risk allele for several types of human cancers. [19][20][21][22] Furthermore, previous studies have indicated that the C-31G SNP is associated with survivin overexpression at mRNA expression levels. 18,20,21 Because survivin overexpression has been associated with progression of many types of cancer, the results are compatible with the fact that the C allele of the C-31G SNP is a risk allele for progression.…”

Section: Discussionmentioning

confidence: 99%

“…Our study results are in contrast with the results of a previous study by Wang et al from Taiwan, which showed the C-31G CC genotype was associated with advanced clinical stage and higher pathological grade in addition to bladder cancer susceptibility in general. 22 Although the exact reason for the discrepancy remains unknown, the difference in other genetic backgrounds between the two nations may affect the effect of survivin SNPs in the multistep carcinogenesis and progression of bladder cancer. Otherwise, the survivin SNPs might have some interaction with dietary and environmental carcinogenic factors that affect distinct stages of bladder cancer development.…”

Section: Discussionmentioning

confidence: 99%

“…5 Several studies have recently explored the possible association between several single-nucleotide polymorphisms (SNPs) of the survivin gene (survivin) and a few types of human cancer. [18][19][20][21][22] Among them, one SNP (C-31G) located at the cell-cycle-dependent element/cell-cycle gene homology region (CDE/CHR) repressor binding motif in the promoter region attracted our attention because it has been shown to be associated with altered expression levels of survivin mRNA and protein with in vitro analysis. 18 Further, in vitro analyses indicated that C-31G SNP changed cell cycle-dependent transcription by modifying the binding motif of the CDE/CHR repressor.…”

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confidence: 99%

“…18 Further, in vitro analyses indicated that C-31G SNP changed cell cycle-dependent transcription by modifying the binding motif of the CDE/CHR repressor. 18 Several case-control studies suggested that the C allele may be a risk allele for several types of human cancer, [19][20][21][22] while a study suggested that this SNP had no significant role in cervical carcinogenesis. 23 On the other hand, we identified the nonsynonymous A9194G (E129K; rs2071214) SNP in exon 4 in the SNP database (http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?…”

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confidence: 99%

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Two survivin polymorphisms are cooperatively associated with bladder cancer susceptibility

Kawata

Tsuchiya

Horikawa

et al. 2011

Intl Journal of Cancer

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Abnormal survivin expression has been reported to be involved in many types of cancer. A single-nucleotide polymorphism (SNP), C-31G, located in the promoter region of survivin reportedly may alter the mRNA level, while the significance of the nonsynonymous SNP A9194G in exon 4 has not yet been clarified. Here, the association between the two survivin SNPs and bladder cancer susceptibility and progression was investigated in 235 patients with bladder cancer and 346 healthy controls. Regarding the C-31G SNP, subjects with the CC genotype had a significantly higher risk of bladder cancer compared to those with the GG 1 CG genotype [odds ratio (OR) 5 1.85, p 5 0.001]. Regarding the A9194G SNP, the presence of the G allele was associated with a significantly reduced risk with a gene dosage effect (OR 5 0.69, p 5 0.002). Using the C-A haplotype as a reference, the G-G haplotype was associated with a significantly lower risk (OR 5 0.11, p 5 0.00006), indicating the cooperative effect of the two SNPs. Immunohistological evaluation of surgical specimens showed that cancer cells of the C-31G CC genotype had significantly higher nuclear survivin expression than those of the C-31G GG 1 CG genotype. With reverse transcriptase-polymerase chain reaction analysis, a significantly higher survivin mRNA expression level was observed in surgical specimens with an increase in the number of the C-31G C allele (p 5 0.016). These results indicate that the two SNPs have a significant and cooperative influence on bladder cancer susceptibility.Bladder cancer is the fourth most common cancer in men and the ninth most common cancer in women in the United States, 1 and it is the sixth most common cancer in men and the 11th most common cancer in women in Japan. 2 The most common type of bladder cancer is transitional cell carcinoma (TCC, also called urothelial carcinoma), and 55-60% of all newly diagnosed bladder cancers are well differentiated or moderately differentiated, superficial (confined to the urothelium or lamina propria) papillary TCCs. Tumor recurrences are observed in majority of these patients after endoscopic resection, with 16-25% of patients developing high-grade tumors. Muscle-invasive or metastatic cancer subsequently develops in 10-20% of patients with superficial papillary TCCs. 1 The 5-year survival rate of this variant is approximately 90%. However, nonpapillary muscle-invasive TCC, which accounts for 20-30% of urothelial malignancies, is invasive at diagnosis and carries a high risk for further invasion and metastasis. At least 50% patients with muscleinvasive cancers generally die within 2 years of diagnosis. 3 Concerning the heterogeneous behavior of bladder TCC, several studies have attempted to identify molecular markers that help clinicians in prognosis of patients with TCC. However, successful applications of molecular markers are limited because of the heterogeneity of molecular genetic alterations in bladder cancer. [4][5][6] Survivin is a protein involved in the inhibition of apoptosis and the control of mito...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Two survivin polymorphisms are cooperatively associated with bladder cancer susceptibility

Kawata

Tsuchiya

Horikawa

et al. 2011

Intl Journal of Cancer

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“…Jaiswal et al (2011) have determined carrying homozygous C allele for -31 G/C polymorphism increases 2.6 fold risk of bladder cancer. Also, homozygous C allele for survivin -31 C/G has been shown that increased cancer risk in urothelial cancer (Wang et al, 2009), bladder cancer (Kawata et al, 2011), nasopharyngeal carcinoma (Ma et al, 2011), esophagus cancer (Upadhyay et al, 2011), prostate cancer (Chen et al, 2013) and colorectal cancer (Gazouli et al, 2009; studies. Yazdani et al (2012) also have demonstrated that GC and CC genotype distributions of survivin -31 G/C polymorphism were found statistically significant differences between thyroid cancer patients and controls.…”

Section: Discussionmentioning

confidence: 99%

Association Between Survivin Gene Polymorphisms and the Susceptibility to Colon Cancer Development in the Turkish Population

Yamak

Yaykaşlı²,

Yılmaz³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Colon cancer is one of the most common cancers worldwide. Apoptosis is a necessary physiological process for cell elimination which is very important both cellular homeostasis and cell proliferation and differantiation. Dysregulation can lead to uncontrolled cell growth and tumor development. Survivin, a member of the IAP family, plays a key role in promotion of cell proliferation as well as inhibition of apoptosis in cancer cells. The aim of this study was to investigate whether specific genetic polymorphisms of survivin could be associated with colon cancer development and progression in a Turkish population. Our study is the first to our knowledge to investigate the relationship between colon cancer risk and survivin gene polymorphisms. Materials and Methods: The relation between colon cancer and survivin -31 G/C (rs9904341), -241 C/T (rs17878467) and -625 C/G (rs8073069) polymorphism in promotor site of survivin gene associated with apoptosis was investigated using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: Individuals with -31C allele and CC genotype were found to have a higher risk of developing colon cancer (OR=13.4, p=0.01). The -241 CT genotype considerably increased the risk of colon cancer (OR=12.0, p=0.0001). However, there was no significant varaition of the survivin -625 C/G polymorphism among colon cancer patients and controls in our study. Conclusions: This study provides the first evidence that survivin -31 G/C and -241 C/T SNP significantly contribute to the risk of colon cancer in the Turkish population.

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The survivin molecule as a double‐edged sword in cellular physiologic and pathologic conditions and its role as a potential biomarker and therapeutic target in cancer

Rafatmanesh

Behjati

Mobasseri

et al. 2019

Journal Cellular Physiology

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Survivin is a member of the family of apoptosis inhibitory proteins with increased expression level in most cancerous tissues. Evidence shows that survivin plays regulatory roles in proliferation or survival of normal adult cells, principally vascular endothelial cells, T lymphocytes, primitive hematopoietic cells, and polymorphonuclear neutrophils. Survivin antiapoptotic role is, directly and indirectly, related to caspase proteins and shows its role in cell division through the chromosomal passenger complex. Survivin contains many genetic polymorphisms that the role of some variations has been proven in several cancers. The −31G/C polymorphism is one of the most important survivin mutations which is located in the promoter region on a CDE/CHR motif. This polymorphism can upregulate the survivin messenger RNA. In addition, its allele C can increase the risk of cancers in 1.27-fold than allele G.

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Association Between Survivin Gene Promoter −31 C/G Polymorphism and Urothelial Carcinoma Risk in Taiwanese Population

Cited by 51 publications

References 25 publications

Two survivin polymorphisms are cooperatively associated with bladder cancer susceptibility

Two survivin polymorphisms are cooperatively associated with bladder cancer susceptibility

Association Between Survivin Gene Polymorphisms and the Susceptibility to Colon Cancer Development in the Turkish Population

The survivin molecule as a double‐edged sword in cellular physiologic and pathologic conditions and its role as a potential biomarker and therapeutic target in cancer

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