Association Between Subcellular Proliferating Membranes and Mitochondria in Dog Thyroid Follicular Cells Induced by Synthetic Double-Stranded Rna Administration

Abstract

The administration of polyriboinosinic-polyribocytidylic acid [poly(rI:rC)], an interferon inducer and antitumour agent, induced proliferating intracellular membranes as well as a characteristic association between those membranes and mitochondria. The membrane-mitochondrion association was most often observed in small mitochondria lying close to the basal cell membrane.