Association between statins and infections after coronary artery bypass grafting

Kayani, Waleed T.; Bandeali, Salman; Lee, Vei Vei; Elayda, MacArthur A.; Khan, Anam; Nambi, Vijay; Jneid, Hani; Alam, Mahboob; Wilson, James M.; Huang, Henry; Birnbaum, Yochai; Ballantyne, Christie M.; Virani, Salim S.

doi:10.1016/j.ijcard.2012.09.060

Cited by 17 publications

(18 citation statements)

References 34 publications

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“…43,[52][53][54][55]59 The remaining 6 found no such effect. 28,30,31,41,57,58 Finally, in an outpatient setting, both studies found a protective effect associated with statin use. 27,56 Retrospective Studies…”

Section: Study Settingmentioning

confidence: 84%

“…[36][37][38][39][40]42,46,49 Twelve studies evaluated patients admitted either to a general ward or to an ICU. 28,30,31,41,43,[52][53][54][55]57,58,59 Two studies were performed in an outpatient setting. 27,56 Of the general ward patient studies, all 6 pointed to a lack of positive effect associated with statin use.…”

Section: Study Settingmentioning

confidence: 99%

“…[27][28][29][30][36][37][38]43,46,48,[52][53][54][55][56]59 The remaining 12 studies found no protective effect associated with statin prophylaxis or therapy. 31,[39][40][41][42]44,45,47,49,57,58,60 Seven studies were unable to report data regarding either statin identification or dosage. 39,40,44,52,54,59,60 Atorvastatin and simvastatin were the most widely used statins.…”

Section: Identification Of Studiesmentioning

confidence: 99%

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Impact of Statins in Outcomes of Septic Patients: A Systematic Review

Tralhão

Souza-Dantas

Salluh

et al. 2014

Postgraduate Medicine

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Section: Study Settingmentioning

confidence: 84%

Section: Study Settingmentioning

confidence: 99%

Section: Identification Of Studiesmentioning

confidence: 99%

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Impact of Statins in Outcomes of Septic Patients: A Systematic Review

Tralhão

Souza-Dantas

Salluh

et al. 2014

Postgraduate Medicine

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“…Epidemiological studies have shown that prior use of statins could be associated with a reduced risk of pneumonia and other acute bacterial infections . Prior use of statins could be associated with a reduced risk of post‐operative infections after cardiac surgery . Prior use of statins could be associated with shorter duration of hospitalization and lower rate of hospital mortality due to acute bacterial infections .…”

Section: Discussionmentioning

confidence: 99%

Statin Use Correlates with Reduced Risk of Pyogenic Liver Abscess: A Population‐Based Case–Control Study

Liao

Cheng

Lin

et al. 2017

Basic Clin Pharma Tox

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Little research is available on the relationship between statin use and pyogenic liver abscess. The objective of the study was to determine whether prior use of statins is associated with pyogenic liver abscess. This case-control study was conducted to analyse the claim data of the Taiwan National Health Insurance Program. There were 1828 participants aged 20-84 years with first episode of pyogenic liver abscess from 2000 to 2013 as the cases and 1828 randomly selected participants without pyogenic liver abscess matched with sex, age and index year as the controls. Statin use was defined as 'current', 'recent' or 'past' if the statin prescription was filled ≤3 months, 3-6 months or >6 months before the date of pyogenic liver abscess diagnosis, respectively. Relative risk of pyogenic liver abscess associated with statin use was estimated by the odds ratio (OR) with 95% confidence interval (CI) using the multivariable logistic regression model. After controlling for potential confounders, the adjusted ORs of pyogenic liver abscess were 0.65 for participants with current use of statins (95% CI 0.50, 0.84), 0.74 for participants with recent use of statins (95% CI 0.49, 1.11), and 1.10 for participants with past use of statins (95% CI 0.90, 1.34), compared with participants with never use of statins. In the further analysis, the adjusted ORs of pyogenic liver abscess were 0.65 for participants with cumulative duration of statin use ≥12 months (95% CI 0.48, 0.88) and 0.68 for participants with cumulative duration of statin use <12 months (95% CI 0.43, 1.07), compared with participants with never use of statins. Our findings provide strong evidence that patients with current use of statins are associated with a 35% reduced odds of pyogenic liver abscess. The protective effect is stronger for longer duration of statin use.

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“…Recently, several studies have demonstrated that IL-20 plays a critical role in tumor progression. IL-20 promotes the migration and invasion of bladder cancer cells by activating ERK pathway-mediated MMP-9 protein expression [8]. Furthermore, IL-20 activates STAT3 and ERK signaling in oral cancer cells to increase cell proliferation and colony formation [9].…”

Section: Introductionmentioning

confidence: 99%

A transcriptional complex composed of ER(α), GATA3, FOXA1 and ELL3 regulates IL-20 expression in breast cancer cells

et al. 2017

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Interleukin-20 (IL-20) is a member of the IL-10 family. IL-20 expression is regulated by a transcription elongation factor, Ell3, in estrogen receptor-positive (ER(+)) breast cancer cells. In this study, we demonstrated that ER(α), GATA3 and FOXA1 form a transcriptional complex with Ell3 to regulate IL-20 expression in ER(+) breast cancer cells. We also determined that GATA3 and FOXA1 share a binding site with ER(α) in the interleukin-20 promoter. Furthermore, we found that FOXA1 represses IL-20 expression, whereas GATA3 and ER(α) activate it. In addition, we demonstrated that Ell3 associates with ER(α) to increase its binding affinity to the IL-20 promoter, which may prevent FOXA1 binding to the same region of this promoter. Our results expand upon the current understanding of the regulatory mechanism of IL-20 in cancer.

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Association between statins and infections after coronary artery bypass grafting

Cited by 17 publications

References 34 publications

Impact of Statins in Outcomes of Septic Patients: A Systematic Review

Impact of Statins in Outcomes of Septic Patients: A Systematic Review

Statin Use Correlates with Reduced Risk of Pyogenic Liver Abscess: A Population‐Based Case–Control Study

A transcriptional complex composed of ER(α), GATA3, FOXA1 and ELL3 regulates IL-20 expression in breast cancer cells

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