Association between statin treatment and LDL-cholesterol levels on the rate of ST-elevation myocardial infarction among patients with acute coronary syndromes: ACS Israeli Survey (ACSIS) 2002–2010

Kolker, Shimon; Nir, Shlomo; Matetzky, Shlomi; Leitersdorf, Eran; Segev, Amit; Goldenberg, Ilan; Tzivoni, Dan; Weisz, Giora; Moriel, Mady

doi:10.1016/j.ijcard.2016.02.088

Cited by 5 publications

(2 citation statements)

References 30 publications

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“…Several studies have shown that patients who were prescribed therapeutic agents for cardiovascular risk factors, such as ACEIs, β-blockers, ASA, and statins, prior to admission, tend to develop NSTEMI rather than STEMI. 22,28,29 There might be underlying mechanisms inhibiting transmural coronary ischemia, such as the pleiotropic effects of statins. 30 We also showed an increasing trend in the pre-development use of therapeutic agents (ACEI/ARBs, β-blockers, CCBs, and OHAs/insulin) in patients with NSTE-ACS over the entire study period.…”

Section: Discussionmentioning

confidence: 99%

Trends Over Time in the Incidences of ST-Segment Elevation Myocardial Infarction and Non-ST-Segment Elevation Myocardial Infarction During the Past Decade in a Rural Japanese High-Aged Population

Ishiguchi

Ishikura

et al. 2021

Circ J

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Section: Discussionmentioning

confidence: 99%

Trends Over Time in the Incidences of ST-Segment Elevation Myocardial Infarction and Non-ST-Segment Elevation Myocardial Infarction During the Past Decade in a Rural Japanese High-Aged Population

Ishiguchi

Ishikura

et al. 2021

Circ J

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“…In a previous study, we have demonstrated that among patients with ACS admitted during 2002-2010, statin use but not LDL-C level < 70 mg/dL was associated with a lower probability of STEMI presentation [14]. We have also evaluated statin pretreatment intensity, demonstrating that patients on HIST had the lowest likelihood of presenting with STEMI.…”

Section: Prior Studiesmentioning

confidence: 99%

Association of Contemporary Statin Pretreatment Intensity and LDL-C Levels on the Incidence of STEMI Presentation

Dadon

Moriel

Iakobishvili

et al. 2021

Life

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Constituting hypolipidemic and pleiotropic effects, statins stabilize coronary artery plaque and may prevent STEMI events. This study investigated the association between contemporary statin pretreatment intensity, low-density lipoprotein cholesterol (LDL-C) levels, and the type of acute coronary syndrome (ACS) presentation: STEMI vs. NSTE-ACS. Data were drawn from the ACS Israeli Survey (ACSIS), a biennial prospective national survey that took place in 2008–2018. The rate of STEMI vs. NSTE-ACS was calculated by statin use, including statin intensity (high-intensity statin therapy (HIST) and low-intensity statin therapy (LIST) prior to the index ACS event. Among 5103 patients, 2839 (56%) were statin-naive, 1389 (27%) used LIST and 875 (17%) used HIST. Statin pretreated patients were older and had a higher rates of co-morbidities, cardiovascular disease history and pretreatment with evidence-based medications. STEMI vs. NSTE-ACS was lower among HIST vs. LIST vs. statin-naive patients (31.0%, 37.8%, and 54.0%, respectively, p for trend < 0.001). Multivariate analysis revealed that HIST was independently associated with lower STEMI presentation (ORadj 0.70; 95% CI 0.57–0.86), while LIST (ORadj 0.92; 95% CI 0.77–1.10) and LDL-C < 70 mg/dL (ORadj 0.96; 95% CI 0.82–1.14) were not. In conclusion, among patients admitted with ACS, pretreatment with HIST was independently associated with a lower probability of STEMI presentation, while LIST and LDL-C < 70 mg/dL were not.

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Phenolic extract from Ocimum basilicum restores lipid metabolism in Triton WR-1339-induced hyperlipidemic mice and prevents lipoprotein-rich plasma oxidation

Touiss

Khatib

Bekkouch

et al. 2017

Food Science and Human Wellness

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Association between statin treatment and LDL-cholesterol levels on the rate of ST-elevation myocardial infarction among patients with acute coronary syndromes: ACS Israeli Survey (ACSIS) 2002–2010

Cited by 5 publications

References 30 publications

Trends Over Time in the Incidences of ST-Segment Elevation Myocardial Infarction and Non-ST-Segment Elevation Myocardial Infarction During the Past Decade in a Rural Japanese High-Aged Population

Trends Over Time in the Incidences of ST-Segment Elevation Myocardial Infarction and Non-ST-Segment Elevation Myocardial Infarction During the Past Decade in a Rural Japanese High-Aged Population

Association of Contemporary Statin Pretreatment Intensity and LDL-C Levels on the Incidence of STEMI Presentation

Phenolic extract from Ocimum basilicum restores lipid metabolism in Triton WR-1339-induced hyperlipidemic mice and prevents lipoprotein-rich plasma oxidation

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