Association between somatic <i>RET</i> mutations and clinical and genetic characteristics in patients with metastatic colorectal cancer

Yang, Yuan-Zhong; Hu, Wanming; Xia, Ling; He, Weiling

doi:10.1002/cam4.4400

Cited by 9 publications

(7 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PRISMA, Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Sharma et al, 2021;Tabchouri et al, 2021;Yang et al, 2021;Zhou et al, 2021;Flood et al, 2022;Iwasaki et al, 2022;McCleary et al, 2022;Meyer et al, 2022;Nagao et al, 2022).…”

Section: Resultsmentioning

confidence: 99%

“…Forty-nine papers were excluded from the review for age-related reasons: six studies had 0–3 patients under age 50. Forty-three studies included patients under age 50 but did not present results stratified by age or did not stratify using an age ≤50 years old for stratification; one study provided above/below-age data but failed to include symbols (≥ or ≤) or descriptive text to indicate which group included the cutoff age (Sternberg et al , 1994; Nakae et al , 1995; Nakamura et al , 1999; Akasu et al , 2000; el-Ghazawy et al , 2001; Luna-Pérez et al , 2002; Al-Shamsi et al , 2003; Kanemitsu et al , 2003; Carmignani et al , 2004; Lloyd et al , 2006; Nervi et al , 2006; Lawson et al , 2008; Sobhani et al , 2008; Song et al , 2009; Aghili et al , 2010; Lemmens et al , 2011; Sjo et al , 2011; Lieu et al ., 2014; Park et al , 2014; Saluja et al , 2014; Adachi et al , 2015; Lam et al , 2015; Sica et al , 2015; Simkens et al , 2015; 2016; Maillet et al , 2016; Wang et al , 2016; Cicero et al , 2017; Hojo et al , 2017; Patil et al , 2017; Cigdem Arslan et al , 2018; Kondo et al , 2021; Melli et al , 2021; Rieser et al , 2021a, 2021b; Sharma et al , 2021; Tabchouri et al , 2021; Yang et al , 2021; Zhou et al , 2021; Flood et al , 2022; Iwasaki et al , 2022; McCleary et al , 2022; Meyer et al , 2022; Nagao et al , 2022).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

A call for standardized reporting of early-onset colorectal peritoneal metastases

Austin-Datta

Vecchia

George

et al. 2023

European Journal of Cancer Prevention

View full text Add to dashboard Cite

BackgroundThe incidence of colorectal cancer (CRC) in patients under 50 years of age, i.e., early-onset CRC, has increased in the past two decades. Colorectal peritoneal metastases (CPM) will develop in 10-30% of CRC patients. CPM traditionally had a dismal prognosis, but surgery and novel systemic treatments appear to increase survival. Determining potential age-associated risk and prognostic factors is optimized when analyses use standardized age groupings. MethodsWe performed a review of early-onset CPM studies and compared variables used, e.g., age stratification and definitions of synchronous and metachronous CPM. We included studies published in PubMed up to November 2022 if results were stratified by age. ResultsOf 114 screened publications in English, only 10 retrospective studies met inclusion criteria. Incidence of CPM was higher in younger CRC patients (e.g. 23% vs. 2% for <25 vs. ≥25 years, P < 0.0001; and 57% vs. 39% vs. 4% for <20 vs. 20-25 vs. >25 years, P < 0.001); two studies reported higher proportion of younger African American CPM patients (e.g. 16% vs. 6% for <50 vs. ≥50 years). Studies used seven different age-stratification methods, presenting comparison challenges. ConclusionStudies showed a higher proportion of CPM in younger patients, but directly comparing results was not possible due to inconsistent reporting. To better address this issue, CRC and CPM studies stratified by standard age groups (e.g. <50 vs. ≥50) are needed.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A call for standardized reporting of early-onset colorectal peritoneal metastases

Austin-Datta

Vecchia

George

et al. 2023

European Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…Another explanation could be our small sample size. Other authors describe NEK2 , MACC1 , REG1A , KIF18A , RET , and TIP60 as possible PM-related cancer genes [ 53 , 54 , 55 , 56 , 57 , 58 ]. In our TSO500 panel, only RET was investigated.…”

Section: Discussionmentioning

confidence: 99%

Predictive Genetic Biomarkers for the Development of Peritoneal Metastases in Colorectal Cancer

Heuvelings

Wintjens

Moonen

et al. 2023

IJMS

View full text Add to dashboard Cite

Metastatic colorectal cancer (CRC) is a common cause of cancer-related mortality, of which peritoneal metastases (PMs) have the worse outcome. Metastasis-specific markers may help predict the spread of tumor cells and select patients for preventive strategies. This exploratory pilot study aimed to gain more insight into genetic alterations in primary CRC tumors, which might be a predictive factor for the development of PM. Forty patients with T3 stage CRC were retrospectively divided in three groups: without metachronous metastases during 5-year follow-up (M0, n = 20), with metachronous liver metastases (LM, n = 10) and with metachronous PM (PM, n = 10). Patients with synchronous metastases were excluded. Primary formalin-fixed paraffin-embedded tumor samples were analyzed via comprehensive genome sequencing (TSO500 analysis) to identify DNA alterations and RNA fusion transcripts in 523 genes and 55 genes, respectively. Thirty-eight samples were included for final analysis. Four M0 tumors and one PM tumor were microsatellite instable. BRAF mutations were uniquely identified in three microsatellite-stable (MSS) PM tumors (37.5%, p = 0.010). RNA analysis showed an additional FAM198A-RAF1 fusion in one PM sample. BRAF p.V600E mutations were only present in PM patients with MSS tumors. Greater attention should be paid to BRAF-mutated tumors in relation to the development of metachronous PM.

show abstract

“…RET, is a transmembrane receptor tyrosine kinase and a receptor for the GDNF-family ligands, which downregulation in CRC tissue compared to healthy tissue was noticed ( 58 ). CRC patients with somatic RET mutations exhibited a lower incidence of liver metastasis but a higher incidence of peritoneal metastasis and more frequently exhibited mucinous histology ( 59 ). On the other hand, a germ-line or somatic RET mutation was linked with more intense and complete angiogenesis in patients with advanced medullary thyroid cancers ( 60 ).…”

Section: Discussionmentioning

confidence: 99%

Plasma protein changes reflect colorectal cancer development and associated inflammation

Urbiola-Salvador,

Jabłońska,

Miroszewska

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

IntroductionColorectal cancer (CRC) is the third most common malignancy and the second leading cause of death worldwide. Efficient non-invasive blood-based biomarkers for CRC early detection and prognosis are urgently needed.MethodsTo identify novel potential plasma biomarkers, we applied a proximity extension assay (PEA), an antibody-based proteomics strategy to quantify the abundance of plasma proteins in CRC development and cancer-associated inflammation from few μL of plasma sample.ResultsAmong the 690 quantified proteins, levels of 202 plasma proteins were significantly changed in CRC patients compared to age-and-sex-matched healthy subjects. We identified novel protein changes involved in Th17 activity, oncogenic pathways, and cancer-related inflammation with potential implications in the CRC diagnosis. Moreover, the interferon γ (IFNG), interleukin (IL) 32, and IL17C were identified as associated with the early stages of CRC, whereas lysophosphatidic acid phosphatase type 6 (ACP6), Fms-related tyrosine kinase 4 (FLT4), and MANSC domain-containing protein 1 (MANSC1) were correlated with the late-stages of CRC.DiscussionFurther study to characterize the newly identified plasma protein changes from larger cohorts will facilitate the identification of potential novel diagnostic, prognostic biomarkers for CRC.

show abstract

Association between somatic RET mutations and clinical and genetic characteristics in patients with metastatic colorectal cancer

Cited by 9 publications

References 19 publications

A call for standardized reporting of early-onset colorectal peritoneal metastases

A call for standardized reporting of early-onset colorectal peritoneal metastases

Predictive Genetic Biomarkers for the Development of Peritoneal Metastases in Colorectal Cancer

Plasma protein changes reflect colorectal cancer development and associated inflammation

Contact Info

Product

Resources

About