Association between social functioning and prefrontal hemodynamic responses in elderly adults

Pu, Shenghong; Nakagome, Kazuyuki; Yamada, Takeshi; Yokoyama, Katsutoshi; Matsumura, Hiroshi; Mitani, Hiroaki; Adachi, Akiko; Kaneko, Koichi

doi:10.1016/j.bbr.2014.06.052

Cited by 15 publications

(10 citation statements)

References 59 publications

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“…This finding is consistent with previous NIRS studies on patients with late-onset major depression [24], in healthy male workers [22] and in healthy adults [23]. In euthymic patients with BD, a functional magnetic resonance imaging (fMRI) study revealed a significant relationship between GAF scores and left dorsolateral prefrontal activation during the VFT [46].…”

Section: Discussionsupporting

confidence: 81%

“…Using SASS and NIRS imaging, previous studies have shown a positive correlation between SASS scores and prefrontal activation during a working memory task in healthy male workers [22], and during a VFT in healthy elderly adults [23]. Pu et al [24] also found that a reduction in frontopolar activation was correlated with lower SASS scores in patients with late-onset major depression.…”

Section: Introductionmentioning

confidence: 78%

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Social Function and Frontopolar Activation during a Cognitive Task in Patients with Bipolar Disorder

Nishimura¹,

Takahashi²,

Ohtani³

et al. 2015

Neuropsychobiology

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Background: It is important to understand the neural basis of functional impairments in patients with bipolar disorder (BD) in order to be able to address the recovery. Recently, neurocognitive impairment emerged as a predictor of psychosocial function. A number of functional brain imaging studies have shown that social function is associated with activation of the prefrontal cortex during a cognitive task in healthy adults, and in patients with major depressive disorder and schizophrenia. However, few studies have been conducted in patients with BD. Methods: We performed multichannel near-infrared spectroscopy (NIRS) imaging to investigate the activation of the prefrontal cortex during a verbal fluency task (VFT). We also used the Social Adaptation Self-Evaluation Scale (SASS) to assess social functioning in patients with BD. Thirty-three depressed patients with BD and 65 age-, gender- and task performance-matched healthy controls (HCs) participated in this study. Results: Depressed patients with BD showed reduced activation in the broader bilateral prefrontal cortex during the VFT compared to HCs. Moreover, a significant positive correlation was observed between the total SASS scores and right prefrontal activation in patients with BD. In the SASS subscores, the interest and motivation factor was also positively correlated with frontopolar activation. Conclusions: These results suggest an association between social function and prefrontal activation in depressed patients with BD. The present study provides evidence that NIRS imaging could be helpful in understanding the neural basis of social function.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 78%

Social Function and Frontopolar Activation during a Cognitive Task in Patients with Bipolar Disorder

Nishimura¹,

Takahashi²,

Ohtani³

et al. 2015

Neuropsychobiology

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“…Notably, a significant positive relationship has been observed between the SASS and interpersonal relationship factor scores and prefrontal cortex activation and between SASS interest and motivation factor scores and prefrontal cortex activation (Pu et al. 2014). …”

Section: Discussionmentioning

confidence: 99%

Genetic association of the transcription of neuroplasticity‐related genes and variation in stress‐coping style

et al. 2015

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IntroductionStress coping has been defined as the cognitive and behavioral efforts made to conquer, endure, or decrease external and internal demands and the conflicts between them. It has two main elements: the control or modification of the person–environment relationship causing the stress (i.e., problem-focused coping) and/or regulation of stressful feelings (i.e., emotion-focused coping). Research suggests that the expressions of brain-derived neurotrophic factor (BDNF) and neurotrophic tyrosine kinase receptor type 2 (NTRK2) play important roles in brain adaptation to investigate stress. To clarify the genetic basis of stress coping, we investigated the association of stress-coping strategies and social adaptation with single-nucleotide polymorphisms (SNPs) involved in neural plasticity, anxiety, and depression.MethodsIn 252 healthy controls (94 women; 158 men), we measured and estimated the stress-coping style using the Lazarus-type stress-coping inventory, ego aptitude scale (EAS), and social adaptation self-evaluation scale (SASS). We investigated one SNP of BDNF (rs6265, Val/Met) and five SNPs of NTRK2 (rs11140800, rs1187286, rs1867283, rs1147198, and rs10868235).ResultsWe observed significant associations between BDNF and emotion-focused strategies, seeking social support, self-control, and distancing. We also found significant associations between NTRK2 and cognitive strategies, problem-solving, confrontive- coping, seeking social support, distancing and positive reappraisal. Significant associations were also found between BDNF and critical attitudes and between NTRK2 and all seven ego-related factors on the EAS. In the SASS, the minor allele rs1867283 of NTRK2 had a significantly higher score than the heterozygote.ConclusionsThese findings may provide insights into the partial effects of genetic mutations in BDNF and NTRK2 on stress tolerance and personality.

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“…Pu et al, showed that prefrontal cortex activity in older adults is associated with their social function, and frontal lobe deficits can lead to functional changes such as apathy, changes in interpersonal relationships, and irritability [17]. Kong et al, also found that social well-being is related to the activities of some regions of the brain, such as bilateral temporal gyrus, right anterior cingulate cortex, and prefrontal cortex.…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Social Function and Social Well-Being in Older Adults

Afshar

Foroughan

Vedadhi

et al. 2017

IRJ

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Objectives: Health refers to the condition of perfect physical, mental and social well-being. The appropriate social well-being is the opposite of loneliness and depression. Social wellbeing is a psychosocial concept that is affected by many factors. This study determined the relationship between social function and social well-being in older adults. Methods:This was a descriptive-analytical study that was conducted on 550 older adults in Tehran. The participants were selected by multistage cluster sampling. Data was collected using Social Well-being Scale and Social Adaptation Self-evaluation Scale. Data were analyzed using Pearson coefficient and linear regression analysis in SPSS v. 22. Results:The mean age of participants was 66.10±6.68 years. The female participants accounted for 41.1% of subjects. There were significant correlations between all aspects of social function (quality of activities and the quality of relationships) and social well-being dimensions (P<0.01). The quality of activities had significant positive effects on all aspects of social well-being (P<0.01), and the quality of relationships also had significant effects on different aspects of social well-being, except on social coherence (P=n.s). Discussion:The findings showed that the social function affects social well-being. So individuals with higher social functioning also have higher social well-being and mental health.

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Association between social functioning and prefrontal hemodynamic responses in elderly adults

Cited by 15 publications

References 59 publications

Social Function and Frontopolar Activation during a Cognitive Task in Patients with Bipolar Disorder

Social Function and Frontopolar Activation during a Cognitive Task in Patients with Bipolar Disorder

Genetic association of the transcription of neuroplasticity‐related genes and variation in stress‐coping style

Relationship Between Social Function and Social Well-Being in Older Adults

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