Association between SNP rs1800875, serum chymase and immunoglobulin E levels in patients with coronary heart disease

Jin, Chunlei; Ma, Hong; Lin, Yan; Wang, Jianan; Xiang, Meixiang

doi:10.1631/jzus.b1101008

Cited by 4 publications

(2 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…59) TNNC1 implicates for heart failure and cardiomyopathies. 60) CMA1 is an ideal candidate for investigating the genetic predisposition to coronary heart disease. 61) BMP7 drives human adipogenic stem cells into metabolically active beige adipocytes.…”

Section: Discussionmentioning

confidence: 99%

Systems Pharmacology Dissection of Mechanisms of Dengzhan Xixin Injection against Cardiovascular Diseases

Wang

Huang

Chen

et al. 2020

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

Dengzhan Xixin injection (DZXXI), a herbal product prepared from a Chinese herb called Erigeron breviscapus, is a classical and traditional therapeutic for cadiovascular diseases (CVDs), including coronary heart disease (CHD), angina, and stroke, etc. However, its potential pharmacology mechanism against CVDs remains unclear. In this paper, a systems pharmacology-based strategy is presented for predicting drug targets and understanding therapeutic mechanisms of DZXXI against CVDs. The main ingredients were identified by HPLC-diode array detector (DAD). The target fishing was performed on the PharmMapper Server (http://lilab-ecust.cn/pharmmapper/). Potential targets were confirmed by two molecular docking tools, Sybyl-X 1.3 and Ledock to ensure the accuracy. The resulting target proteins were applied as baits to fish their related diseases and pathways from the molecular annotation system (MAS 3.0, http://bioinfo. capitalbio.com/mas3/) and Kyoto Encyclopedia of Genes and Genomes (KEGG) database (http://www. genome.jp/kegg/). Network generation and topological analysis were performed in Cytoscape 3.6.0. 15 main ingredients from DZXXI were identified. Forty five putative drug targets and 50 KEGG pathways, which have highly relevance to the therapeutic effects of DZXXI against CVDs, were then obtained. The systems analysis suggested that DZXXI could attenuate cardiac fibrosis, regulate cardiac contractility, and preserve heart function in adverse cardiac remodeling; meanwhile DZXXI also could have the function of activating blood circulation and dilating blood vessels. DZXXI exerts its therapeutic effects on CVDs possibly through multi-targets including CMA1, epidermal growth factor receptor (EGFR), phenylalanine-4-hydroxylase (PAH), SRC, F7, etc., and multi-pathways including Focal adhesion, mitogen-activated protein kinase (MAPK) signaling pathway, complement and coagulation cascades, Wnt signaling pathway, vascular endothelial growth factor (VEGF) signaling pathway, Renin-angiotensin system, etc.

show abstract

Section: Discussionmentioning

confidence: 99%

Systems Pharmacology Dissection of Mechanisms of Dengzhan Xixin Injection against Cardiovascular Diseases

Wang

Huang

Chen

et al. 2020

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

show abstract

“…Chymase, tryptase, and cathepsin G can degrade vascular endothelial cadherin, a molecule involved in the survival signaling of endothelial cells 93 . Even though one study reported that there was no correlation between serum chymase level and CAD 94 , it is local release of chymase and other mediators that would be important. Tryptase further leads to inflammation through protease activated receptors (PARs), that are also present on MC and can be stimulated by thrombin.…”

Section: Introductionmentioning

confidence: 96%

Stress triggers coronary mast cells leading to cardiac events

Alevizos

Karagkouni

Panagiotidou

et al. 2014

Annals of Allergy, Asthma & Immunology

View full text Add to dashboard Cite

Association of allergic rhinitis, coronary heart disease, cerebrovascular disease, and all-cause mortality

Yoon

Chiu

Rana

et al. 2016

Annals of Allergy, Asthma & Immunology

View full text Add to dashboard Cite

Association between SNP rs1800875, serum chymase and immunoglobulin E levels in patients with coronary heart disease

Abstract: Polymorphism rs1800875 of CMA1 may be associated with serum IgE level in CHD subjects, but not with chymase level in both groups. In GG homozygotes, high IgE level is a protective factor against coronary disease.

Cited by 4 publications

References 33 publications

Systems Pharmacology Dissection of Mechanisms of Dengzhan Xixin Injection against Cardiovascular Diseases

Systems Pharmacology Dissection of Mechanisms of Dengzhan Xixin Injection against Cardiovascular Diseases

Stress triggers coronary mast cells leading to cardiac events

Association of allergic rhinitis, coronary heart disease, cerebrovascular disease, and all-cause mortality

Contact Info

Product

Resources

About