Association between small fiber neuropathy and higher skin accumulation of advanced glycation end products in patients with type 1 diabetes

Araszkiewicz, Aleksandra; Gandecka, Agnieszka; Nowicki, Michał; Uruska, Aleksandra; Malińska, Agnieszka; Kowalska, Katarzyna; Wierusz‐Wysocka, Bogna; Zozulińska‐Ziółkiewicz, Dorota

doi:10.20452/pamw.3649

Cited by 14 publications

(11 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…20 AGE formation and accumulation are observed in endoneurium, Schwann cells, extracellular matrix, microvessels of peripheral nerve fibers, and the skin. 21 AGEs can be also dissolved in blood and have specific receptors. Skin AF as a marker of AGEs was validated with the use of skin biopsies in which skin AF measurements were compared with markers of glycation such as glycated collagen and specific AGE [pentosidine, N(epsilon)-(carboxymethyl)lysine and N (epsilon)-(carboxyethyl)lysine levels] in healthy individuals patients with T2D and patients with T1D.…”

Section: Characteristicmentioning

confidence: 99%

Association Between Self-reported Physical Activity and Skin Autofluorescence, a Marker of Tissue Accumulation of Advanced Glycation End Products in Adults With Type 1 Diabetes: A Cross-sectional Study

Duda-Sobczak¹,

Falkowski²,

Araszkiewicz

et al. 2018

Clinical Therapeutics

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Characteristicmentioning

confidence: 99%

Association Between Self-reported Physical Activity and Skin Autofluorescence, a Marker of Tissue Accumulation of Advanced Glycation End Products in Adults With Type 1 Diabetes: A Cross-sectional Study

Duda-Sobczak¹,

Falkowski²,

Araszkiewicz

et al. 2018

Clinical Therapeutics

Self Cite

View full text Add to dashboard Cite

show abstract

“…Our earlier results showed a relationship between skin AF and the presence of peripheral neuropathy and its correlation with IENFD. 13,25 Interestingly, we found a much stronger correlation between ESC and skin AF than with HbA 1c levels. From all the mechanisms involved in the pathogenesis of diabetic neuropathy, one of the most important element is the increased formation of AGEs, just as is the alternating activity of glucose through the polyol pathway, increased expression of the nuclear factor NF -kB, and the activation of the mitogen -activated protein kinase signaling pathway during hyperglycemia.…”

Section: Resultsmentioning

confidence: 62%

Evaluation of sudomotor function in adult patients with long lasting type 1 diabetes

Gandecka¹,

Araszkiewicz²,

Piłaciński³

et al. 2017

Polish Archives of Internal Medicine

Self Cite

View full text Add to dashboard Cite

INTRODUCTION The function of the sweat glands appears to be impaired in patients with diabetic complications.OBJECTIVES The aim of the study was to evaluate sudomotor function in adult patients with type 1 diabetes (DM1) and healthy controls and its relationship with metabolic control and diabetic complications. .5-78.5 μS), P <0.001). In the study group, there was a negative correlation between ESC and patients' age, duration of diabetes, waist -to -hip ratio, skin autofluorescence, vibration perception threshold, as well as hemoglobin A 1c and triglyceride levels, and a positive correlation with estimated glomerular filtration rate. Microvascular complications were diagnosed in 73.3% of the patients. Patients with retinopathy, diabetic kidney disease, peripheral neuropathy, and cardiac autonomic neuropathy had lower ESC in the feet and hands compared with those without complications. In multivariate logistic regression models, ESC was associated with the presence of any microvascular complications independently of potential confounders.CONCLUSIONS Diabetic microangiopathy, and in particular neuropathy, is related with reduced sudomotor function in DM1. A longer duration of diabetes, worse metabolic control, and reduced renal function are associated with greater sudomotor dysfunction.ORIGINAL ARTICLE Sudomotor function in patients with type 1 diabetes 17 Therefore, the aim of this study was to evaluate sudomotor function using the SUDOSCAN+ device in adult patients with DM1 and healthy controls, as well as to assess the relationship of sudomotor function with metabolic control and diabetic complications. PATIENTS AND METHODS PatientsOur study involved 404 patients (194 women) with DM1, treated at

show abstract

“…HbA 1c reflects mean glycaemia during the last 3 months. Skin autofluorescence has been shown to be higher in people with diabetes than in healthy controls [7], and it also correlates with the results of AGE accumulation in skin biopsies and with HbA 1c levels [8]. AGEs act through specific receptors [5] and stimulate inflammatory reactions and oxidative stress, leading to cell damage.…”

Section: Introductionmentioning

confidence: 99%

“…Chronic hyperglycaemia promotes the creation of advanced glycation end products (AGEs), which play a crucial role in the pathogenesis of diabetic angiopathy. Moreover, skin autofluorescence is related to the development and progression of chronic diabetic complications [8,9]. AGEs may be assessed in the serum but also non-invasively in the skin by measuring skin autofluorescence [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…AGEs may be assessed in the serum but also non-invasively in the skin by measuring skin autofluorescence [6,7]. Skin autofluorescence has been shown to be higher in people with diabetes than in healthy controls [7], and it also correlates with the results of AGE accumulation in skin biopsies and with HbA 1c levels [8]. Moreover, skin autofluorescence is related to the development and progression of chronic diabetic complications [8,9].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Accumulation of advanced glycation end products in the skin is accelerated in relation to insulin resistance in people with Type 1 diabetes mellitus

et al. 2019

View full text Add to dashboard Cite

Aim To evaluate the association between skin advanced glycation end products and insulin resistance in Type 1 diabetes.Methods The study group consisted of 476 people with Type 1 diabetes (247 men) with a median (interquartile range) age of 42 (33-53) years, disease duration of 24 (19-32) years and HbA 1c concentration of 63 (55-74) mmol/mol [7.9 (7.2-8.9)%]. Insulin resistance was assessed according to estimated glucose disposal rate. Advanced glycation product accumulation in the skin was measured by autofluorescence using an AGE Reader. The group was divided into three subgroups based on estimated glucose disposal rate tertiles (<5.5, 5.5-9.5 and >9.5 mg/kg/min, respectively). The higher the estimated glucose disposal rate, the lower the insulin resistance.Results Skin autofluoresence level decreased with increasing estimated glucose disposal rate; comparing people below the lower tertile, with those between the first and third tertiles, and with those above the third tertile, the median autofluoresences were, respectively: 2.5 (2.2-2.9) vs 2.3 (2.0-2.7) vs 2.1 (1.9-2.5) AU (P<0.0001). A negative correlation was observed between skin autofluorescence and estimated glucose disposal rate (Spearman's correlation coefficient=-0.31, P <0.001). Multiple logistic regression showed a significant, two-way association of insulin resistance with skin autofluorescence.Conclusion The results of this study offer strong evidence for a two-way relationship between insulin resistance and advanced glycation product accumulation in the skin in people with Type 1 diabetes.

show abstract

Association between small fiber neuropathy and higher skin accumulation of advanced glycation end products in patients with type 1 diabetes

Cited by 14 publications

References 1 publication

Association Between Self-reported Physical Activity and Skin Autofluorescence, a Marker of Tissue Accumulation of Advanced Glycation End Products in Adults With Type 1 Diabetes: A Cross-sectional Study

Association Between Self-reported Physical Activity and Skin Autofluorescence, a Marker of Tissue Accumulation of Advanced Glycation End Products in Adults With Type 1 Diabetes: A Cross-sectional Study

Evaluation of sudomotor function in adult patients with long lasting type 1 diabetes

Accumulation of advanced glycation end products in the skin is accelerated in relation to insulin resistance in people with Type 1 diabetes mellitus

Contact Info

Product

Resources

About