Association between sleep quality and inflammatory complement components in collegiate males

Manzar, Dilshad; Rajput, Mohammad Muntafa; Zannat, Wassilatul; Hameed, Unaise Abdul; Al-Jarrah, Muhammed; Spence, D. Warren; Pandi-Perumal, Seithikurippu R.; BaHammam, Ahmed S.; Hussain, M. Ejaz

doi:10.1007/s11325-015-1249-0

Cited by 9 publications

(6 citation statements)

References 39 publications

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“…CD35 binds C3b and C4b therefore, theoretically, it may decrease C3a production as well (Ricklin et al, 2016). Another study found an indirect relationship between factor I and sleep duration in healthy subjects (Manzar et al, 2016). Factor I is responsible for C3b and C4b degradation, again both acting on C3a and C5a production (Ricklin et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Complement system activation in obstructive sleep apnea

Horváth

Tárnoki

et al. 2018

Journal of Sleep Research

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The complement system may play a role in the systemic inflammation characterising obstructive sleep apnea; however, this has not been investigated before. We aimed to study the involvement of effector complement elements in obstructive sleep apnea, namely C3a, C5a and SC5b-9. Venous blood was collected in 50 patients with obstructive sleep apnea and 26 control subjects in the evening and the following morning. Plasma complement proteins were analysed with ELISA. Complement factor levels were compared between the two groups and correlated with clinical variables. Plasma C3a concentration was elevated in obstructive sleep apnea both in the evening (84.1 [0-338.5] ng ml ) and in the morning (85.5 [0-247.8] ng ml ) compared with controls (30.3 [0-176.8] ng ml and 36.3 [0-167.1] ng ml , evening and morning, respectively, both p < 0.05). On the contrary, C5a and SC5b-9 levels were comparable between patients and controls at each time point (p > 0.05). There was no change in complement factors from evening to morning in either group (p > 0.05), except for C5a that decreased from evening to morning in obstructive sleep apnea (from 11.6 [1.6-47.4] ng ml to 9.3 [0-46.4] ng ml , p = 0.01). Elevated C3a levels were directly related to obstructive sleep apnea severity, and were significantly associated with male gender, weight, body mass index, hypertension, high C-reactive protein and low high-density lipoprotein cholesterol (p < 0.05). The complement system is activated in obstructive sleep apnea, which is correlated with disease severity. Our findings highlight the potential role of complement system in the pathophysiology of obstructive sleep apnea, thus facilitating further research.

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Section: Discussionmentioning

confidence: 99%

Complement system activation in obstructive sleep apnea

Horváth

Tárnoki

et al. 2018

Journal of Sleep Research

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“…Sleep plays, indeed, an important role in the daily life of healthcare professions students, and is implied in the occupational risks of the future doctor and allied health professional (including night work, work-related stress and burn-out, workplace violence, among others) [10]. Furthermore, sleep is also relevant for the immunological and mental health of students [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Sleep Disturbances Rate among Medical and Allied Health Professions Students in Iran: Implications from a Systematic Review and Meta-Analysis of the Literature

Khaksarian

Behzadifar

et al. 2020

IJERPH

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Medicine and healthcare professions are prestigious and valued careers and, at the same time, demanding, challenging, and arduous jobs. Medical and allied health professions students, experiencing a stressful academic and clinical workload, may suffer from sleep disturbances. In Iran, several studies have been conducted to explore the prevalence rate among medical and healthcare professions students. The aim of this systematic review and meta-analysis was to quantitatively and rigorously summarize the existing scholarly literature, providing the decision- and policy-makers and educators with an updated, evidence-based synthesis. Only studies utilizing a reliable psychometric instrument, such as the Pittsburgh sleep quality index (PSQI), were included, in order to have comparable measurements and estimates. Seventeen investigations were retained in the present systematic review and meta-analysis, totaling a sample of 3586 students. Studies were conducted between 2008 and 2018 and reported an overall rate of sleep disturbances of 58% (95% confidence interval or CI 45–70). No evidence of publication bias could be found, but formal analyses on determinants of sleep disturbances could not be run due to the dearth of information that could be extracted from studies. Poor sleep is highly prevalent among Iranian medical and healthcare professions students. Based on the limitations of the present study, high-quality investigations are urgently needed to better capture the determinants of poor sleep quality among medical and healthcare professions students, given the importance and the implications of such a topic.

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“…Using a mouse model devoid of C5 complement signaling, rhythmic HPSC recruitment could be entirely blocked, implicating the importance of circadian complement pathway activation in immune surveillance (Massberg et al, 2007;Janowska-Wieczorek et al, 2012;Ratajczak et al, 2012;Budkowska et al, 2018). While this study implicates rhythmic complement activation in the context of circulating HPSCs, other studies have shown a sleep-dependent increases in C3, C4, C3a, C5a, and complement factor I (CFI) ultimately resulting in dysregulated cytokines production (Reis et al, 2011;Manzar et al, 2016;Horvath et al, 2018;Wadhwa et al, 2019). Using the Pittsburgh Sleep Quality Index (PSQI) in a relatively small number of male university students, Manzar et al demonstrated that poor sleep quality correlates with decreased proinflammatory C3 and C4 in the serum and increased levels of anti-inflammatory CFI during early bedtime and daytime (Manzar et al, 2015), suggesting that regular sleep patterns may be important for the normal cycling of complement factors.…”

Section: Co-regulatory Roles Of Complement and Sleep On Immunosurveilmentioning

confidence: 75%

Circadian Clock and Complement Immune System—Complementary Control of Physiology and Pathology?

Shivshankar

Fekry

Eckel‐Mahan

et al. 2020

Front. Cell. Infect. Microbiol.

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Mammalian species contain an internal circadian (i.e., 24-h) clock that is synchronized to the day and night cycles. Large epidemiological studies, which are supported by carefully controlled studies in numerous species, support the idea that chronic disruption of our circadian cycles results in a number of health issues, including obesity and diabetes, defective immune response, and cancer. Here we focus specifically on the role of the complement immune system and its relationship to the internal circadian clock system. While still an incompletely understood area, there is evidence that dysregulated proinflammatory cytokines, complement factors, and oxidative stress can be induced by circadian disruption and that these may feed back into the oscillator at the level of circadian gene regulation. Such a feedback cycle may contribute to impaired host immune response against pathogenic insults. The complement immune system including its activated anaphylatoxins, C3a and C5a, not only facilitate innate and adaptive immune response in chemotaxis and phagocytosis, but they can also amplify chronic inflammation in the host organism. Consequent development of autoimmune disorders, and metabolic diseases associated with additional environmental insults that activate complement can in severe cases, lead to accelerated tissue dysfunction, fibrosis, and ultimately organ failure. Because several promising complement-targeted therapeutics to block uncontrolled complement activation and treat autoimmune diseases are in various phases of clinical trials, understanding fully the circadian properties of the complement system, and the reciprocal regulation by these two systems could greatly improve patient treatment in the long term.

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Association between sleep quality and inflammatory complement components in collegiate males

Abstract: The findings indicate the importance of the role of complement components in the dynamics of sleep. Therefore, sleep should be assessed in conditions where complement components are affected.

Cited by 9 publications

References 39 publications

Complement system activation in obstructive sleep apnea

Complement system activation in obstructive sleep apnea

Sleep Disturbances Rate among Medical and Allied Health Professions Students in Iran: Implications from a Systematic Review and Meta-Analysis of the Literature

Circadian Clock and Complement Immune System—Complementary Control of Physiology and Pathology?

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