Association between six genetic variants of IL-17A and IL-17F and cervical cancer risk: a case–control study

Lv, Qiongying; Zhu, Dingjun; Zhang, Juan; Yi, Yuexiong; Zhang, Wei

doi:10.1007/s13277-015-3041-y

Cited by 23 publications

(20 citation statements)

References 30 publications

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“…Our previous studies confirmed that the genotypes of IL-17A rs2275913 may play an important role in the development of cervical cancer, particularly in patients with HPV-16 or HPV-18 infection (20). Moreover, it has been confirmed that HPSE silencing significantly reduced the invasiveness of cervical cancer cells (21).…”

Section: Interleukin-17a and Heparanase Promote Angiogenesis And Cellsupporting

confidence: 72%

Interleukin‑17A and heparanase promote angiogenesis and cell proliferation and invasion in cervical cancer

Liu

et al. 2018

Int J Oncol

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Interleukin‑17A (IL‑17A) is a CD4 T-cell-derived pro-inflammatory cytokine that is involved in human cervical tumorigenesis. Heparanase (HPSE) is an endo-glycosidase expressed in mammals, which has been confirmed to be associated with cervical cancer invasion. In the present study, it was hypothesized that IL‑17A and HPSE are key proteins promoting tumor angiogenesis and cell proliferation and invasion in cervical cancer. The expression of IL‑17A and HPSE in cervical cancer tissues was detected by immunohistochemical staining. In addition, the expression of IL‑17A and HPSE was down- and upregulated via RNAi and human recombinant proteins, and MTT and Transwell assays were performed to examine cervical cancer cell proliferation and invasion, respectively. Flow cytometry analysis was also performed to detect cell cycle distribution, and the levels of target mRNA and protein were evaluated by reverse transcription-quantitative polymerase chain reaction and western blotting, respectively. IL‑17A and HPSE were highly expressed in cervical cancer tissues, and microvessel density was notably higher in the IL‑17A-positive group. IL‑17A and/or HPSE recombinant protein promoted the proliferation and invasion of cervical cancer cells, increased the proportion of cells in the G2/M phase, and enhanced the mRNA and protein expression of human papillomavirus E6, P53, vascular endothelial growth factor and CD31, whereas downregulation of IL‑17A and/or HPSE exerted the opposite effects. Furthermore, downregulation of IL‑17A and/or HPSE was found to inhibit the expression of nuclear factor (NF)-κB P65. In summary, IL‑17A and HPSE may promote tumor angiogenesis and cell proliferation and invasion in cervical cancer, possibly via the NF-κB signaling pathway. These findings may lead to the identification of new diagnostic markers and therapeutic targets.

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Section: Interleukin-17a and Heparanase Promote Angiogenesis And Cellsupporting

confidence: 72%

Interleukin‑17A and heparanase promote angiogenesis and cell proliferation and invasion in cervical cancer

Liu

et al. 2018

Int J Oncol

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“…To date, many molecular epidemiological studies have been conducted to evaluate the relationship between IL-17A rs2275913 G > A and IL-17F rs763780 T > C polymorphisms and several kinds of cancers and diseases, such as acute myeloid leukemia, non-small cell lung cancer, colorectal cancer, papillary thyroid cancer, cervical cancer, hepatocellular carcinoma, and coronary artery disease (Wróbel et al, 2014;Cheng et al, 2015;ELBassuoni et al, 2015;Geng et al, 2015;Ma et al, 2015;Lee et al, 2015;Lv et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Association between IL-17A and IL-17F gene polymorphisms and risk of gastric cancer in a Chinese population

et al. 2016

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ABSTRACT. We conducted a case-control study to investigate the role of interleukin-17A (IL-17A) rs2275913 G > A and IL-17F rs763780 T > C polymorphisms in the development of gastric cancer. A hospitalbased case-control design was performed, and 153 patients and 207 control subjects were consecutively selected from the Third Affiliated Hospital between May 2013 and December 2014. Polymerase chain reaction-restriction fragment length polymorphism was used to genotype for IL-17A rs2275913 G > A and IL-17F rs763780 T > C. The genotypes of IL-17A rs2275913 G > A and IL-17F rs763780 T > C did not deviate from Hardy-Weinberg equilibrium (P values were 0.44 and 0.11, respectively). By unconditional logistic regression analysis, we observed that the GG genotype of rs2275913 was associated with an increased risk of gastric cancer compared to the AA genotype [odds ratio (OR) = 2.66; 95% confidence interval (CI) = 1.26-5.66]. The AG + GG genotype of rs2275913 increased the susceptibility to gastric cancer compared to the AA genotype, and the adjusted OR (95%CI) was 2.66 (1. 26-5.66). Moreover, the GG genotype of rs2275913 was correlated with an elevated risk of gastric cancer when compared with the AA + AG genotype (OR = 2.15; 95%CI = 1.08-4.34). In conclusion, we found that the IL-17A rs2275913 G > A gene polymorphism was significantly associated with an increased risk of gastric cancer in codominant, dominant, and recessive models.

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“…A wide range of inter-individual genetic variability in CC susceptibility and other pathogeneses might contribute to cervical carcinogenesis, such as the genetic factor. Accumulating evidence suggests that single nucleotide polymorphisms (SNPs) in tumor-associated genes play an important role in the genetic susceptibility to CC (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Genetic Polymorphisms of PGF and TNFAIP2 Genes Related to Cervical Cancer Risk Among Uygur Females from China

Ainiwaer

Maisaidi

Liu

et al. 2020

Preprint

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Abstract Background: PGF and TNFAIP2 are important angiogenic factors, which were abnormal expression in cervical cancer (CC). However, no report was investigating the associations between the polymorphisms in the PGF and TNFAIP2 genes and CC risk. Methods: We conducted a case-control study of 342 CC patients and 498 cancer-free controls in Chinese Uygur female population. Three selected SNPs (PGF rs8019391, PGF rs2268615, and TNFAIP2 rs710100) were genotyped to investigate the possible association of the polymorphisms in PGF and TNFAIP2 with the risk of CC. The analysis adjusted by age was used to assess associations of these SNPs with CC risk. Results: PGF rs2268615 (OR = 1.39, 95% CI = 1.04-1.86, p = 0.024) and TNFAIP2 rs710100 (OR = 1.44, 95% CI =1.07-1.95, p = 0.018) polymorphisms were significantly associated with the increased risk of CC. Moreover, PGF rs8019391 T allele was highly represented in patients with III–IV tumor stage (OR = 2.17, p = 4.58´10-4). MDR analysis revealed a positive interaction between the SNPs. Conclusion: Our data suggested that PGF rs2268615, and TNFAIP2 rs710100 polymorphisms may be risk factors for susceptibility to CC, which contributed to the increased risk of CC, and this finding requires further validation by larger studies.Trail registration: Not applicable.

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Association between six genetic variants of IL-17A and IL-17F and cervical cancer risk: a case–control study

Cited by 23 publications

References 30 publications

Interleukin‑17A and heparanase promote angiogenesis and cell proliferation and invasion in cervical cancer

Interleukin‑17A and heparanase promote angiogenesis and cell proliferation and invasion in cervical cancer

Association between IL-17A and IL-17F gene polymorphisms and risk of gastric cancer in a Chinese population

Genetic Polymorphisms of PGF and TNFAIP2 Genes Related to Cervical Cancer Risk Among Uygur Females from China

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